Herbicidal triazines

ABSTRACT

Aryl and heteroaryl sulfonimidamides which also contain a pyrimidine or triazine heterocycle are useful as general or selective preemergent and postemergent herbicides.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a division of copending application Ser. No. 753,117, filed on July 11, 1985, now U.S. Pat. No. 4,666,506, which is a continuation-in-part of copending application Ser. No. 638,963, filed Aug. 8, 1984, now abandoned.

BACKGROUND OF THE INVENTION

This invention concerns sulfonimidamide herbicides that contain a pyrimidine or triazine heterocycle.

Preparation of an inactive sulfonimidamide analogue of tolbutamide is disclosed in J. Org. Chem. 1979, 44, 2055. Herbicidal sulfonamides are known in the art; see, for example, U.S. Pat. Nos. 4,127,405 and 4,169,719.

SUMMARY OF THE INVENTION

This invention relates to these compounds of Formula I, agriculturally suitable compositions containing them and their use as preemergent herbicides, postemergent herbicides, and/or plant growth regulants: ##STR1## wherein R is H or CH₃ ;

G is O or NR₁ ;

R₁ is H, C₁ to C₃ alkyl, CF₂ H, C₂ to C₃ alkyl substituted with 1 to 3 atoms of F, CH₂ CH₂ OCH₃, CH₂ CH₂ OH, CH₂ CH₂ OSi(CH₃)₃, OH, OSi(CH₃)₃, C₁ to C₂ alkoxy, SO₂ CH₃, phenyl or benzyl; ##STR2## R₂ is C₁ to C₄ alkyl, C₁ to C₄ alkoxy, OCH₂ CH₂ OCH₃, F, Cl, Br, C₁ to C₂ haloalkoxy, C₁ to C₂ haloalkylthio, C₁ to C₂ haloalkylsulfonyl, C₂ to C₃ alkylcarbonyl, NO₂, CO₂ R₁₇, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃, OSO₂ R₂₀, S(O)_(p) R₂₁, C₃ to C₄ alkenyloxy, C₃ to C₄ alkynyloxy, C₁ to C₂ alkyl substituted with OCH₃, OCH₂ CH₃, 1 to 3 atoms of F or Cl, or with 1 Br, C₂ to C₃ alkenyl optionally substituted with 1 to 3 F or Cl, C₆ H₅, ##STR3## R₃ is H, F, Cl, Br, CF₃, CH₃, CH₂ CH₃, OCH₃, OCF₂ H, OC₂ H₅, C₁ to C₂ alkylthio, CH₂ SCH₃, CH₂ OCH₃ or C₁ to C₂ alkoxy substituted with 1 to 3 F;

R₄ is H, CH₃, OCH₃, F, Cl, Br, SO₂ N(CH₃)₂, OSO₂ CH₃ or SO₂ CH₃ ;

R₅ is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, F, Cl, Br, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃ or SO₂ R₂₁ ;

R₆ is F, Cl, Br, NO₂, CO₂ R₁₇, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃ or SO₂ R₂₁ ;

R₇ is H or C₁ to C₄ alkyl;

R₈ is H or CH₃ ;

R₉ is H or CH₃ ;

R₁₀ is H or C₁ to C₄ alkyl;

R₁₁ is H or CH₃ ;

R₁₂ is H, C₁ to C₆ alkyl, C₂ to C₃ alkoxycarbonyl, C₂ to C₃ alkylcarbonyl or C₂ to C₄ alkyl substituted with Cl, Br, OCH₃ or OC₂ H₅, or with 1 to 3F;

R₁₃ is H or C₁ to C₃ alkyl;

R₁₄ is H or CH₃ ;

R₁₅ is H or C₁ to C₃ alkyl;

R₁₆ is C₁ to C₃ alkyl, F, Cl, Br, NO₂, CO₂ R₁₇, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃, SO₂ R₂₁ or OCF₂ H;

R₁₇ is C₁ to C₄ alkyl, CH₂ CH₂ OCH₃, CH₂ CH₂ Cl or CH₂ CH═CH₂ ;

R₁₈ is C₁ to C₃ alkyl;

R₁₉ is C₁ to C₃ alkyl;

R₂₀ is C₁ to C₃ alkyl or N(CH₃)₂ ;

R₂₁ is C₁ to C₃ alkyl or CH₂ CH═CH₂ ;

m is 0 or 1;

p is 0, 1 or 2;

Q₁ is O or SO₂ ;

Q₂ is O or S; ##STR4## X is CH₃, OCH₃, OCH₂ CH₃, Cl, F, Br, I, OCF₂ H, CH₂ F, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃ or CF₃ ;

Y is H, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, CH₂ OCH₂ CH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, C₂ H₅, CF₃, SCH₃, OCH₂ C.tbd.CH, amino, CH₂ S(O)CH₃, CH₂ SO₂ CH₃, C.tbd.CH, C.tbd.CCH₃, OCH₂ CH═CH₂, OCH₂ CH₂ OCH₃, CH₂ SCH₃, ##STR5## SCF₂ H or cyclopropyl; n is 2 or 3;

Q₃ and Q₄ are independently O or S;

Q₅ is O or NR₂₅ ;

R₂₂ is H or CH₃ ;

R₂₃ and R₂₄ are independently C₁ to C₂ alkyl;

R₂₅ is H or C₁ to C₃ alkyl;

R₂₆ is H or Cl;

R₂₇ is H or Cl;

R₂₈ is H or CH₃ ;

Z is CH or N;

Y₁ is O or CH₂ ;

X₁ is H, CH₃ or OCH₃ ;

Y₂ is H or CH₃ ;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₃ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, OCF₂ H, SCF₂ H, CH₃ or C₂ H₅ ;

X₃ is CH₃ or OCH₃ ;

Y₄ is CH₃, OC₂ H₅, OCH₃ or Cl; and

X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl;

and their agriculturally suitable salts; provided that

(a) when X is Cl, F, Br or I, then Z is CH and Y is OCH₃, OC₂ H₅, N(OCH₃)CH₃, NHCH₃, N(CH₃)₂, OCF₂ H or amino;

(b) when m is 1, then R₉ is H;

(c) the total number of carbon atoms of R₁₈ and R₁₉ does not exceed four;

(d) when L is L-15, then R₁₃ and R₁₄ are not simultaneously H;

(e) when X or Y is OCF₂ H, then Z is CH;

(f) when L is L-16, then R₁₆ is adjacent to the substituent ##STR6## and (g) when the total number of carbon atoms of X and Y is greater than four, then R₁ is H or CH₃ and the total number of carbons of the substituents on L does not exceed four.

In the above definitions, the term "alkyl" used either alone or in compound words such as "alkylthio" or "haloalkyl", denotes straight chain or branched alkyl, e.g., methyl, ethyl, n-propyl, isopropyl or the different butyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propoxy, isopropoxy and the different butoxy isomers.

Alkenyl denotes straight chain or branched alkenes, e.g., vinyl, 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers.

Alkynyl denotes straight chain or branched alkynes, e.g., ethynyl, 1-propynyl, 2-propynyl and the different butynyl isomers.

The term "halogen", either alone or in compound words such as "haloalkyl", denotes fluorine, chlorine, bromine or iodine.

Alkylcarbonyl denotes acetyl or propionyl.

Alkoxycarbonyl denotes methoxy- or ethoxycarbonyl.

In terms such as C₂ to C₃ alkylthioalkyl, the specified number of carbon atoms is meant to define the total number of carbon atoms in that substituent group. For example, C₂ to C₃ alkylthioalkyl would designate CH₂ SCH₃, CH₂ SC₂ H₅, CH₂ CH₂ SCH₃ or CH(CH₃)SCH₃, and C₂ to C₅ alkoxyalkoxy would represent OCH₂ OCH₃ through O(CH₂)₄ OCH₃ or OCH₂ O(CH₂)₃ CH₃ and the various structural isomers embraced therein.

Preferred for reasons of their higher herbicidal activity, greater plant growth regulant activity and/or more favorable ease of synthesis are:

(1) Compounds of Formula I where G is O; and R is H;

(2) Compounds of Formula I where G is NR₁ ; R is H; and R₁ is H, C₁ to C₂ alkyl, CH₂ CF₃ or CF₂ H;

(3) Compounds of Preferred Group 1 where Y is CH₃, OCH₃, CH₂ OCH₃, C₂ H₅, NHCH₃, cyclopropyl or CH(OCH₃)₂ ; and R₁ is H, C₁ to C₂ alkyl, CH₂ CF₃ or CF₂ H;

(4) Compounds of Preferred Group 3 where

R₂ is C₁ to C₃ alkyl, C₁ to C₃ alkoxy, Cl, Br, NO₂, CF₃, CO₂ R₁₇, SO₂ N(CH₃)₂, OSO₂ R₂₀, ##STR7## R₃ is H, Cl, CH₃ or OCH₃ ; R₄ is CH₃, OCH₃, Cl, Br, OSO₂ CH₃ or SO₂ CH₃ ;

R₅ is Cl, SO₂ N(CH₃)₂ or SO₂ CH₃ ;

R₆ is Cl, NO₂, CO₂ R₁₇, SO₂ N(CH₃)₂ or SO₂ R₂₁ ;

R₇ is H or CH₃ ;

R₉ is H;

R₁₀ is H or CH₃ ;

R₁₁ is H;

R₁₂ is H or C₁ to C₄ alkyl;

R₁₃ is H or CH₃ ;

R₁₅ is CH₃ ;

R₁₆ is C₁ to C₂ alkyl, Cl, Br, NO₂, CO₂ CH₃, SO₂ N(CH₃)₂, SO₂ R₂₁ or OCF₂ H;

R₁₇ is C₁ to C₃ alkyl;

R₂₀ is C₁ to C₃ alkyl;

R₂₁ is C₁ to C₂ alkyl;

R₂₅ is H or CH₃ ;

R₂₈ is H;

Q₂ is O;

A is A-1; and

X is CH₃, OCH₃, OC₂ H₅, Cl, OCF₂ H or OCH₂ CF₃ ;

(5) Compounds of Preferred Group 4 where L is L-1; and R₂ is CH₃, C₂ H₅, CF₃, Br, Cl or SO₂ R₂₁ ;

(6) Compounds of Preferred Group 4 where L is L-5; and R₆ is Cl or SO₂ R₂₁ ;

(7) Compounds of Preferred Group 4 where L is L-7;

(8) Compounds of Preferred Group 4 where L is L-9;

(9) Compounds of Preferred Group 4 where L is L-10;

(10) Compounds of Preferred Group 4 where L is L-15;

(11) Compounds of Preferred Group 4 where L is L-16; and R₁₆ is C₁ to C₂ alkyl, Cl, Br or SO₂ R₂₁ ;

(12) Compounds of Preferred Group 2 where

L is L-1, L-5, L-7, L-9, L-10, L-15 or L-16;

R₂ is C₁ to C₃ alkyl, C₁ to C₃ alkoxy, Cl, Br, NO₂, CF₃, CO₂ R₁₇, SO₂ N(CH₃)₂, OSO₂ R₂₀, ##STR8## R₃ is H, Cl, CH₃ or OCH₃ ; R₄ is CH₃, OCH₃, Cl, Br, OSO₂ CH₃ or SO₂ CH₃ ;

R₅ is Cl, SO₂ N(CH₃)₂ or SO₂ CH₃ ;

R₆ is Cl, NO₂, CO₂ R₁₇, SO₂ N(CH₃)₂ or SO₂ R₂₁ ;

R₇ is H or CH₃ ;

R₉ is H;

R₁₀ is H or CH₃ ;

R₁₁ is H;

R₁₂ is H or C₁ to C₄ alkyl;

R₁₃ is H or CH₃ ;

R₁₅ is CH₃ ;

R₁₆ is C₁ to C₂ alkyl, Cl, Br, NO₂, CO₂ CH₃, SO₂ N(CH₃)₂, SO₂ R₂₁ or OCF₂ H;

R₁₇ is C₁ to C₃ alkyl;

R₂₀ is C₁ to C₃ alkyl;

R₂₁ is C₁ to C₂ alkyl;

R₂₅ is H or CH₃ ;

R₂₈ is H;

Q₂ is O;

A is A-1; and

X is CH₃, OCH₃, OC₂ H₅, Cl, OCF₂ H or OCH₂ CF₃ ; Specifically preferred for reason of higher herbicidal activity and/or more favorable ease of synthesis are:

(i) 2-bromo-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-N'-methylbenzenesulfonimidamide, m.p. 120° to 125° C.;

(ii) 2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-N'-methylbenzenesulfonimidamide, m.p. 154° to 160° C.; and

(iii) N-[(4,6,-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(methylsulfonyl)benzenesulfonimidamide, m.p. 135° to 145° C.(d).

DETAILED DESCRIPTION OF THE INVENTION Synthesis

The compounds of Formula I can be prepared by one or more of the methods described in Equations 1 to 4 and 16. ##STR9## where A, L, R and R₁ are as previously defined, except that for this method R₁ cannot be CH₂ CH₂ OH or OH; R₂, R₆, and R₁₆ cannot be CO₂ R₁₇ ; and L cannot be L-10, L-13, L-14, or L-15.

Reaction of a sulfonimidamide or a sulfonodiimidamide (1) with an appropriate methylpyrimidinyl carbamate or methyltriazinyl carbamate (2) in the presence of at least an equimolar amount of trimethylaluminum leads to compounds of Formula I.

The reaction of Equation 1 is best run in either dichloromethane or 1,2-dichloroethane solution at 20° to 85° C. for 10 to 96 hours under a nitrogen or argon atmosphere. The product can be isolated by addition of an aqueous acetic acid solution followed by extraction of the product into dichloromethane, or by filtration of a product of low solubility. The product can be purified by trituration with solvents such as 1-chlorobutane or ethyl ether, by recrystallization from mixtures of solvents such as 1,2-dichloroethane, 1-chlorobutane, and heptane, or by column chromatography on silica gel.

Many of the compounds of Formula I can be prepared by the method shown in Equation 2. ##STR10## where

A, L, R and R₁ are as previously defined, except that for this method R₁ cannot be CH₂ CH₂ OH or OH.

In this method a solution of compound (1) in anhydrous pyridine at -30° to 30° C. is treated with at least one equivalent of phenyl chloroformate. After 1 to 8 hours the solvent is evaporated, and the residue is taken up in a mixture of dichloromethane and water. The mixture is acidified with concentrated hydrochloric acid to pH 4, and the dichloromethane layer is separated, and dried over sodium sulfate. Evaporation of the dichloromethane leaves carbamate (3) (Equation 2a).

Many variations on the above conditions and reagents are possible. With compounds (1) stable to stronger bases, mixtures of aqueous sodium or potassium hydroxide and tetrahydrofuran or dioxane may replace the pyridine. Alternatively, mixtures of potassium carbonate in tetrahydrofuran at 0° to 65° C. in the presence or absence of 4-dimethylaminopyridine may replace the pyridine.

With very strong base and polar aprotic solvent combinations such as sodium hydride in N,N-dimethylformamide, or lithium diisopropyalamide or n-butyl-lithium in tetrahydrofuran or dioxane, diphenyl carbonate may replace the phenyl chloroformate. Of course, when strong or very strong bases are employed, at least two equivalents of the base is required, and acidification is necessary in the course of isolating carbamate (3).

The desired compounds of Formula I are prepared by contacting the phenyl carbamates of Formula (3) with equimolar amounts of the appropriate heterocyclic amines of Formula (4) in an inert solvent such as 1,4-dioxane or tetrahydrofuran at 20° to 102° C. for 0.5 to 24 hours. The products can be isolated by evaporation of the reaction solvent and can be purified by trituration with a solvent such as 1-chlorobutane or ethyl ether, by recrystallization from mixtures of solvents such as 1,2-dichloroethane, 1-chlorobutane, and heptane, or by column chromatography in silica gel.

Alternatively, most of the compounds of Formula I where R is H can be prepared by the method shown in Equation 3. ##STR11## where

A, L, and R₁ are as previously defined, except that for this method R₁ cannot be CH₂ CH₂ OH or OH.

Equimolar amounts of compound (1) and a heterocyclic phenyl carbamate (5) in a polar aprotic solvent such as acetonitrile or 1,4-dioxane at 0° to 40° C. are treated with an equimolar amount of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (Equation 3). Following one procedure, the mixture is diluted with ice-water and acidified to pH 4-5 with hydrochloric or acetic acid. If the product crystallizes, it is collected, rinsed with ice-water and dried. If it does not, the aqueous solution is extracted with dichloromethane, and the dichloromethane solution is dried and evaporated to provide the product of Formula I in crude form. Alternatively, the reaction mixture is evaporated, and the residue is acidified with acetic acid to give the product of Formula I contaminated with phenol and the acetate salt of DBU. The product I can be purified by trituration with a solvent such as 1-chlorobutane or ethyl ether, by recrystallization from mixtures of solvents such as 1,2-dichloroethane, 1-chlorobutane, and heptane, or by column chromatography on silica gel.

The phenyl carbamates (5) can be prepared by methods, or modifications thereof known to those skilled in the art, described in South African Patent Application No. 825671 and South African Patent Application 825045.

Many of the compounds of Formula I can be prepared by the method shown in Equation 4. ##STR12## where

A, L, R, and R₁ are as previously defined, except that for this method R₁ cannot be CH₂ CH₂ OH or OH.

In this method compounds of Formula I are prepared by reacting compounds (6) with appropriate amino or alkylamino heterocycles (4) (Equation 4).

The reactions are best carried out in inert aprotic organic solvents such as dichloromethane, 1,2-dichloroethane, tetrahydrofuran, or acetonitrile, at a temperature between 20° and 85° C. The order of addition is not critical; however, it is often convenient to add the sulfonimidoyl or sulfonodiimidoyl isocyanate or a solution of it in the reaction solvent to a stirred suspension of the amine.

Compounds (6) are generally prepared from the respective compounds (1) (see Equations 14 and 15). Occasionally a compound (1) may not be sufficiently stable to be useful as an intermediate. In these cases, as well as others, the requisite compound (6) can be reacted with the heterocyclic amine (4) by treating the corresponding sulfonimidoyl chloride or sulfonodiimidoyl chloride with the isocyanate anion in the presence of the amine (see Equation 16 and accompanying discussion).

In some cases, the desired product is insoluble in the reaction solvent at ambient temperature and crystallizes from it in pure form. Products soluble in the reaction solvent are isolated by evaporation of the solvent. Compounds of Formula I then can be purified by trituration of the evaporation residue with solvents such as 1-chlorobutane or ethyl ether and filtration, by recrystallization from mixtures of solvents such as 1,2-dichloroethane, 1-chlorobutane, and heptane or by chromatography on silica gel.

Compounds of Formula I where R₁ is CH₂ CH₂ OH or OH can be prepared from the corresponding silyl compounds of Formula I where R₁ is CH₂ CH₂ OSi(CH₃)₃ or OSi(CH₃)₃ simply by dissolving the silyl compounds in methanol at 20° to 30° C. and after analytical thin layer chromatography indicates the desilylation is complete (typically 10 minutes to 2 hours), evaporating the solvent. L, R, and A are as previously defined.

Compounds (1) can be prepared by one or more of the following methods.

Many compounds (1) are prepared by reaction of the corresponding compounds (7) with ammonia or a protected form of ammonia from which the protecting group is subsequently removed (Equation 5). ##STR13## where

L and R₁ are as previously defined except that R₁ is not CH₂ CH₂ OH or OH in (7) in Equations 5a and 5b. In Equation 5c when R₁ is CH₂ CH₂ OSi(CH₃)₃ in (9) then R₁ becomes CH₂ CH₂ OH in (1) and when R₁ is OSi(CH₃)₃ in (9) then R₁ becomes OH in (1). R₁ can also be C(CH₃)₃ (tert-butyl or t-Bu) except that in Equation 5c when R₁ and R₂₅ are both t-Bu in (9) then R₁ becomes H in (1). R₁ can also be Si(CH₃)₃ except that in Equation 5c when R₁ is Si(CH₃)₃ in (9), R₁ becomes H in (1). In Equation 5c when R₁ is benzyl and R.sub. 29 is t-Bu in (9), then R₁ becomes H in (1).

R₂₉ is C(CH₃)₃ or ##STR14##

In this method a solution of the compound (7) in a suitable anhydrous solvent, such as dichloromethane, at -70° to -80° C. is treated with at least two equivalents (only two equivalents when R₂, R₆, or R₁₆ is CO₂ R₁₇) of ammonia. The reaction mixture is allowed to warm to 20° C. and then is shaken with water. If the products of Formula (1) are present as undissolved solids, they are filtered and dried. Otherwise, the dichloromethane solution is dried over sodium sulfate, and the solvent is evaporated to leave product (1) (Equation 5a).

Although it is the most direct route, the ammonia reaction frequently gives large amounts of polymeric by-products. For this reason, the method illustrated by Equations 5b and 5c is generally preferred. In this method, a solution of compound (7) in a suitable anhydrous solvent such as dichloromethane at -70° to -80° C. is treated with at least two equivalents (little more than two equivalents when R₂, R₆, or R₁₆ is CO₂ R₁₇) of tert-butylamine or with a little more than one equivalent of 4,4'-dimethoxybenzhydrylamine and a little more than one equivalent of triethylamine. Additional triethylamine may be useful if the starting materials containing (7) also contain acidic by-products from the formation of (7). The reaction mixture is then warmed to room temperature.

When R₂₉ is tert-butyl, the solvent is evaporated, and the residue is taken up in dichloromethane, washed with aqueous sodium bicarbonate solution, and dried over sodium sulfate. Evaporation of the solvent leaves the compound (9) (Equation 5b).

When R₂₉ is 4,4'-dimethoxybenzhydryl the reaction mixture is washed with aqueous sodium carbonate solution and dried over sodium sulfate. The solvent is evaporated and the residue is taken up in toluene. Evaporation of the toluene leaves compound (9) (Equation 5b).

Crude product (9) can be purified by a variety of methods known in the art including chromatography and recrystallization as appropriate.

The compound (9) is dissolved in trifluoroacetic acid at room temperature. Trifluoroacetic acid by itself rapidly removes the 4,4'-dimethoxybenzhydryl protecting group. However, when R₂₉ is tert-butyl at least one equivalent of anisole and a very strong acid such as trifluoromethanesulfonic acid are added. The reaction is run for 0.5 to 16 hours at room temperature.

Then, if trifluoroacetic acid has been used alone, the solvent is evaporated. The residue is dissolved in a mixture of dichloromethane and a small amount of water. Sodium or potassium bicarbonate and carbonate are added until the mixture is basic. The mixture is dried over sodium sulfate, filtered, and further dried over this desiccant. Evaporation of the solvent leaves free compound (1) (Equation 5c).

If an additional strong acid has been employed, sodium acetate is added in an amount sufficient to neutralize the strong acid present. The solvent is evaporated, and the residue is dissolved in a mixture of dichloromethane and a small amount of water. Sodium or potassium carbonate is added until the mixture is basic. The mixture is dried, and the solvent is evaporated as described in the preceding paragraph to give free compound (1) (Equation b 5c).

Crude product (1) can be purified by a variety of methods known in the art including chromatography and recrystallization as appropriate. Some of the reactions in Equation 5 (e.g., Equation 5c) cause a cleavage of trimethylsilyl groups such that when R₁ is CH₂ CH₂ OSi(CH₃)₃ and OSi(CH₃)₃ in (7), it becomes CH₂ CH₂ OH and OH, respectively, in (1). Such purification procedures as chromatography can also effect this cleavage. To replace the trimethylsilyl groups, one or more of a variety of general methods for silyl ether formation reviewed by T. W. Greene in Protective Groups in Organic Synthesis, Wiley-Interscience, New York, 1981, can be used to convert the R₁ substituents in (1) of CH₂ CH₂ OH and OH to CH₂ CH₂ OSi(CH₃)₃ and OSi(CH₃)₃, respectively.

In some cases, R₁ can be such that the precursors to compounds (7) are not easily prepared or are unstable. In these cases as well as many others, the requisite compound (1) can be prepared by the methods shown in Equations 6 and 7. ##STR15## where L is as previously defined;

R₁ is C₁ -C₃ alkyl, CF₂ H, C₂ -C₃ alkyl substituted with 1-3 atoms of F, CH₂ CH₂ OCH₃, CH₂ CH₂ OH or SO₂ CH₃ ; and

X' is Cl, Br, I, ##STR16## R₁ X' (10) can be ##STR17## also.

In this method, a solution of compound (1a) (prepared via the method described in Equation 5) in a suitable solvent such as N,N-dimethylformamide is treated with one equivalent of a suitable strong base such as sodium hydride containing catalytic sodium tert-butoxide. The mixture is then treated with at least one equivalent of R₁ X' (10). The reaction is run at 20° to 100° C. for 0.5 to 16 hours. When R₁ X' (10) is a highly reactive reagent such as (R₁)₃ O⁺ BF₄ ⁻ or CH₃ SO₂ Cl, little more than one equivalent of (10) is used, a solvent like dichloromethane is used in place of the N,N-dimethylformamide, a base like N,N-diisopropylethylamine is used in place of the sodium hydride-tert-butoxide mixture, and the reaction temperature is reduced to 0° to 40° C.

To work up the reaction, the solvent is evaporated and the residue is dissolved in a mixture of dichloromethane and water. When R₁ is SO₂ CH₃, the mixture is acidified to pH 4 with hydrochloric acid. The dichloromethane layer is separated and dried over sodium sulfate. Evaporation of the solvent leaves sulfonimidamide (9a) (Equation 6a).

Sulfonodiimidamide (1b) (prepared via the method described in Equation 5) is converted to sulfonodimidamide (11) by the method already described for the conversion of (1a) to (9a) in Equation 6a (Equation 6b).

Compounds (9 and 11) are converted to (1) as already described for Equation 5c (Equations 6c and 6d).

Finally, sulfonodiimidamide (12) is converted to (1) (G=NR₁) by the method already described for the conversion of (1a) to (9a) in Equation 6a (Equation 6e).

Alternatively, as shown in Equation 7 the free compound (1b) can be reacted directly with alkylating, benzylating, and sulfonating reagents to give N-substituted derivatives of Formula (1). This method is especially useful for the preparation of N-substituted sulfonimidamides of Formula (1) where the N-substituent R₁ is unstable to the strong acid needed to cleave the tert-butyl group in the method depicted in Equation 6. Benzyl is usually cleaved by the necessary strong acid, and methanesulfonyl may be cleaved in some cases. A relative disadvantage of the method depicted in Equation 7 is that polyalkylation side reactions may be more significant in some cases than with the method depicted in Equation 6. This dis-advantage becomes an advantage in the preparation of N-substituted sulfonodiimides of Formula (1) (G=NR₁), since the necessary bis-substitution may be carried out in a single step. ##STR18## where L, R₁, X' and R₁ X' are as defined for Equation 6, except that R₁ can also be benzyl.

Unsubstituted compound (1b) (G=O) is converted to N-substituted (1) (G=O) by the general method already described for the conversion of (1a) to (9a) in Equation 6a (Equation 7a). Similarly, unsubstituted sulfonodiimidamide (1b) (G=NR₁) is converted to N,N'-disubstituted sulfonodiimidamide (G=NR₁) by the method already described for the conversion of (1a) to (9a) in Equation 6a except that twice as much base and R₁ X' (10) is used (Equation 7).

Sulfonimidoyl chlorides and sulfonodiimidoyl chlorides of Formula (7) can be prepared by one or more of the following methods.

In the most generally useful method, compounds (13) are chlorinated to give compounds (7), as shown in Equation 8. ##STR19## where L and R₁ are as defined for (7) in Equation 5.

In this method, compound (13) is treated with at least one equivalent (only one equivalent when other sensitive functionalities are present) of chlorine or other chlorinating agent such as tert-butyl hypochlorite or N-chlorobenzotriazole according to the general procedures, or modifications thereof known to those skilled in the art, described by C. R. Johnson and co-workers (see C. R. Johnson, E. U. Jonsson, C. C. Bacon, J. Org. Chem., 44, 2055 (1979), and C. R. Johnson, A. Wambsgans, J. Org. Chem., 44 2278 (1979)) to give sulfonimidoyl chloride (7) (Equation 8). In general, the use of chlorine is preferred from the standpoint of cost and convenience. However, when other sensitive functionalities are present, N-chloro-benzotriazole and particularly tert-butyl hypochlorite may be more useful.

Some of compounds (7) can be prepared from the corresponding compounds (14) as shown in Equation 9. ##STR20## where L and R₁ are as defined for (7) in Equation 5, except that R₁ is not H, CF₂ H, OSi(CH₃)₃, phenyl or benzyl.

In this method, compound (14) is treated with slightly more than one equivalent of Cl₂ NR₁ (15); see E. S. Levchenko, L. N. Markovskii, A. V. Kirsanov, Zh. Org. Khim., 3, 1481 (1967); J. Org. Chem. USSR., 3, 1439 (1967) and C. R. Johnson, E. U. Jonsson, C. C. Bacon op. cit. to give sulfonimidoyl chloride (7) (Equation 9).

The requisite N,N-dichloro reagents (15) are either known in the art or can be made from the corresponding free amino compounds H₂ NR₁ (16) by following general procedures such as those described by E. S. Levchenko, A. V. Kirsanov in Zh. Obshch. Khim., 30, 1553 (1960); J. Gen. Chem. USSR, 30, 1562 (1960)). The requisite amino compounds H₂ NR₁ (16) are known or capable of preparation by a variety of methods known in the art.

The preparation of the requisite compounds (14) is described further below.

Compounds (13) (G=O) are prepared by one or more of a variety of methods known in the art. A number of these methods are tabulated in Equation 10. ##STR21## where L and R₁ are as defined in Equation 8 except that R₁ is not CF₂ H. In Equation 10c, R₁ is not SO₂ CH₃. In Equation 10e, M is Li or Mg, and L is restricted to structures where methodology is known for regioselective preparation of stable organometallic reagents (20).

In the first and probably most common method, a solution of compound (14a) in a suitable solvent such as dichloromethane at -80° to -70° C. is treated with at least two equivalents (only two equivalents when R₂, R₆, or R₁₆ is CO₂ R₁₇) of H₂ NR₁ (16). When H₂ NR₁ (16) is not trivially accessible or is relatively nonbasic, one equivalent of a suitable base such as triethylamine may be substituted for one of the two equivalents of H₂ NR₁ (16). The reaction mixture is warmed to -10° to 30° C. and is then washed with water and dried over sodium sulfate. Evaporation of the solvent leaves sulfinamide (13a) (Equation 10a). The requisite amino compounds H₂ NR₁ (16) are either known in the art or can be made by a wide variety of methods known in the art.

Sulfinamides (13a) can be prepared from the corresponding sulfinic acids (17), the amino compounds H₂ NR₁ (16), and a coupling agent according to the general procedures of M. Furukawa and T. Okawara in Synthesis, 339 (1976) and M. Furukawa, T. Ohkawara, Y. Noguchi, M. Nishikawa and M. Tomimatsu in Chem. Pharm. Bull., 28, 134 (1980) (Equation 10b).

Sulfinamides (13a) can be prepared from the corresponding activated sulfinamides (18) and the amino compounds H₂ NR₁ (16) according to the general procedure of D. N. Harpp and T. G. Back in J. Org. Chem., 38, 4328 (1973) (Equation 10c). Methods for the preparation of the activated sulfinamides (19) are disclosed in the paper by Harpp and Back and the references cited therein.

Sulfinamides (13a) can be prepared by oxidation of the corresponding sulfenamides (19) according to the general procedure of M. Haake, H. Gebbing, and H. Benack in Synthesis 1979, 97 (Equation 10d). Sulfenamides (19) are prepared from the corresponding sulfenyl chlorides LSCl (22) and other compounds by the methods reviewed by A. Schoberl and A. Wagner "Methoden zur Herstellung und Umwandlung von Sulfensauren and Sulfensaurederivaten" in Methoden Org. Chem. (Houben-Weyl), Vol. 9,263 (1955); D. R. Hogg "Sulphenic Acids and Their Derivatives in Comprehensive Organic Chemistry, Vol. 3, D. N. Jones ed., Pergamon Press, New York, 1979 and E. Kuhle The Chemistry of the Sulfenic Acids, Georg Thieme, Stuttgart, 1973.

Finally, in some cases sulfinamides (13a) can be prepared from organometallic reagents and N-sulfinylamines (21) according to the general procedure of D. Klamann, C. Sass, and M. Zelinka in Chem. Ber., 92, 1910 (1959) (Equation 10e). The preparation of N-sulfinylamines has been reviewed by G. Kresze, A. Maschke, R. Albrecht, K Bederke, H. Patzschke, H. Smalla, A. Trede in Angew. Chem., Int. Ed. Engl., 1, 89 (1962); and by G. Kresze, W. Wucherpfennig in Angew. Chem., Int. Ed. Engl., 6, 149 (1967).

Although not shown in Equation 10, in some cases sulfinamides (13a) can be prepared from sulfoximides according to the general procedure of R. Sato, N. Saito, Y. Takikawa, S. Takizawa, and M. Saito in Synthesis 1983, 1045. For general reviews of the preparation of sulfinamides (13a) by some of the methods already described and others, see F. Muth "Methoden zur Herstellung und Unwandlung von Aromatischen Sulfinsauren" in Methoden Org. Chem. (Houben-Weyl), Vol. 9, 299 (1955) and K. K. Andersen "Sulphinic Acids and Their Derivatives" in Comprehensive Organic Chemistry, Vol. 3, D. N. Jones ed., Pergamon Press, New York, 1979.

Compounds (13) (G=NR₁) are prepared by one or more of the methods shown in Equation 11. ##STR22## where L, M and R₁ are as defined for Equation 10.

In the first and most general method, sulfenamide (19) is converted to sulfinimidoyl chloride (15a) using the same general procedures, or modifications thereof known to those skilled in the art, already noted for the conversion of (13) to (7) in Equation 8 (Equation 11a). Then sulfinimidoyl chloride (15a) is converted to sulfinimidamide (13b) using the same general procedure, or modifications thereof known to those skilled in the art, already noted for the conversion of (14) to (13) in Equation 10a (Equation 11b). Alternatively, in some cases a sulfinimidamide of Formula (13b) can be prepared by condensation of the appropriate organometallic reagent (20) with the appropriate sulfur diimide (23) using the same general procedure, or modifications thereof obvious to those skilled in the art, already noted for the conversion of (20) and (21) to (13a) in Equation 10e (Equation 11c). Methods for the preparation of sulfur diimides have been reviewed by C. R. Johnson, "Sulfur Di-imines" in Comprehensive Organic Chemistry, Vol. 3, D. N. Jones ed., Pergamon Press, New York, 1979.

In some cases, when R₂, R₆ or R₁₆ is CO₂ R₁₇, the methods shown in Equations 6, 7, 10 and 11 can be complicated by side reactions involving intramolecular closure between a sulfur-attached nitrogen atom and the ester carbonyl carbon atom. In some of these cases as well as others when R₂, R₆ and R₁₆ is CO₂ R₁₇, this tendency to intramolecular closure can be used to advantage. The closure is effected when the bridging sulfur is in low oxidation state as shown in Equation 12. ##STR23## where p is 0 or 1 and R₁₇ is as previously defined.

In this method, a solution of a sulfinyl chloride of Formula (14a) or a sulfenyl chloride of Formula (22a) in a suitable solvent such as dichloromethane at -80° to -60° C. is treated with at least two equivalents of ammonia. The mixture is warmed to about 0° C. and at this temperature is treated with at last two equivalents of a suitable strong base such a 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). The reaction mixture is warmed and held at 20° to 40° C. for 0.5 to 8 hours. The solution is then washed with aqueous 1N hydrochloric acid and dried over sodium sulfate. Evaporation of the solvent leaves the cyclic sulfinamide of Formula (24) or sulfenamide of Formula (25) respectively (Equation 12).

The cyclic sulfinamides of Formula (24) and sulfenamides of Formula (25) are then converted to cyclic compounds of Formula (26) by use of methods and procedures, or modifications thereof obvious to those skilled in the art, analogous to those already discussed in connection with Equations 5, 6, 7, 8 and 11.

The cyclic compounds (26) are then opened to give the corresponding sulfonimidamides of Formula (1c) as shown in Equation 13. ##STR24## where G is as previously defined;

R₁ is as previously defined, except that when R₁ is CH₂ CH₂ OSi(CH₃)₃ or OSi(CH₃)₃ in (26) ,R₁ becomes CH₂ CH₂ OH or OH, respectively, in (lc); and

R₁₇ is as previously defined.

In this method a solution or suspension of a cyclic compound (26) in R₁₇ OH (27) is treated with a suitable acid catalyst such as hydrogen chloride. The mixture is heated at 50° to 100° C. for 1 to 6 hours. The solvent is evaporated, and the residue is dissolved in dichloromethane containing a small amount of water. The mixture is neutralized with sodium bicarbonate and dried over excess sodium sulfate. Evaporation of the solvent leaves the compound (1c) (Equation 13).

Compounds of Formula (1c) where R₁ is CH₂ CH₂ OSi(CH₃)₃ or OSi(CH₃)₃ can be prepared from the corresponding compounds of Formula (1c) where R₁ is CH₂ CH₂ OH or OH respectively as noted previously for compounds of Formula (1) in the discussion following Equation 5.

Sulfinyl chlorides (14) are prepared by treatment of either the corresponding sulfinic acids (17) or their salts with thionyl chloride, or by oxidation of the corresponding thiols or thiol derivatives with chlorine or another chlorinating agent. Potentially suitable thiol derivatives include disulfides, sulfenyl chlorides (22), and especially thiolesters. Sulfinic acids (17) are prepared by a variety of methods including the reduction of the corresponding sulfonyl halides or other sulfur derivatives; the oxidation of the corresponding thiols or thio derivatives; the reaction of sulfur dioxide with diazonium salts, with organometallic reagents LM (20), or directly with suitable aromatic hydrocarbons via a Friedel-Crafts procedure; and the cleavage of sulfones.

For reviews of many of the methods for making sulfinic acids and sulfinyl chlorides, see F. Muth (op. cit.) and K. K. Andersen (op. cit.).

Sulfonyl chlorides are prepared by a wide variety of methods known in the art. Some of these methods include the chlorination of the corresponding sulfur compounds of lower oxidation state such as thiols, sulfides, disulfides, xanthates, isothiocyanates, thiosulfates, and isothiouronium salts. Other methods include the coupling of diazonium salts with sulfur dioxide and chlorine ion in the presence of Cu (II), and the reaction of chlorosulfonic acid with suitable aromatic hydrocarbons. Finally, one general method involves the preparation of sulfonyl chlorides from the corresponding sulfonic acids or their salts. A variety of methods exists in the art for the preparation of sulfonic acids. For reviews of many of the methods for making sulfonic acids and sulfonyl halides, see H. Eckaldt "Sulfochlorierung nach C. F. Reed" in (Houben-Weyl), Vol. 9, 407 (1955); F. Muth "Methods zur Herstellung und Umwandlung Aromatischer Sulfonsauren" in (Houben-Weyl), Vol. 9, 429 (1955), F. Muth "Methoden zur Herstellung und Umwandlung Aromatische Sulfohalogenide" in (Houben-Weyl), Vol. 9, 557 (1955); K. K. Andersen "Sulfonic Acids and Their Derivatives" in Comprehensive Organic Chemistry, Vol. 3, D. N. Jones ed., Pergamon Press, New York, 1979; and the reviews cited therein.

Sulfenyl chlorides LSCl (22) are generally prepared by chlorination of the corresponding disulfides, thiols or certain thiol derivatives such as benzyl sulfides and thiolesters as reviewed by D. R. Hogg (op. cit.). Thiols and thiol derivatives such as sulfides, disulfides, xanthates, thiolesters, isothiocyanates, and isothiouronium salts are prepared by a variety of methods known in the art. Some of these methods include the reaction of sulfur-based nucleophiles with aromatic diazonium salts or with aromatic systems containing a halogen atom or other leaving group suitable to nucleophilic displacement. Other methods include the reaction of sulfur or other sulfur electrophiles with organometallic reagents LM (20). Still other methods include the reaction of active sulfur based electrophiles such as sulfur monochloride with suitable aromatic hydrocarbons via a Friedel-Crafts type procedure. Highly useful methods such as the Newman-Kwart rearrangement and related procedures are known in the art for conversion of a hydroxyl group to thiol derivatives.

In addition to being preparable by the above noted substitution-type reactions, many heteroaromatic thiols and thiol derivatives are prepared by a variety of methods in which the sulfur atom has been incorporated into a nonheteroaromatic precursor to the heterocyclic system. For reviews of many of the methods for making thiols and thiol derivatives, see A. Schoberl and A. Wagner "Methoden zur Herstellung und Umwandlung von Mercaptamen und Thiophenolen" in (Houben-Weyl), Vol. 9, 3 (1955); A. Schoberl and A. Wagner "Methoden zur Herstellung und Umwandlung von Disulfiden" in (Houben-Weyl), Vol. 9, 55 (1955); A. Schoberl and A. Wagner "Methoden zur Herstellung und Umwandlung von Mercaptalen und Mercaptolen" in (Houben-Weyl), Vol. 9, 195 (1955); A. Schoberl and A. Wagner "37 . . . Sulfensauren und Sulfensaurederivate" (op. cit.); G. C. Barrett "Thiols" in Comprehensive Organic Chemistry, Vol. 3, D. N. Jones ed.; Pergamon Press, New York, 1979; D. R. Hogg (op. cit.); E. Kuhle additional review of many of the methods for making carbon-sulfur bonds see D. Martin "37 Formation of Carbon-Sulfur Bonds" in Preparative Organic Chemistry, G. Hilgetag and A. Martini ed., Wiley-Interscience, 1972.

The construction of the aromatic nucleus of L and the introduction and elaboration of substituents, including any needed for the introduction of the sulfonimidoylurea or sulfonodiimidoylurea bridge sulfur atom as noted above, are accomplished using methods known in the ar, or modifications thereof obvious to those skilled in the art. In particular, for cases where L is L-1 and R₂ is a heterocycle, reference to the useful methods taught in European Patent Publications 83,975 (published July 20, 1983) and 85,476 (published Aug. 10, 1983) is suggested. For cases where L is L-7, L-8, L-9, L-10, L-11, L-12, L-13, L-14 or L-15, reference to the useful methods taught in European Patent Application (EP-A) No. 107,979 (published May 9, 1984) is suggested.

Compounds (6) are prepared from the corresponding compounds (1) by one of the following three general methods. ##STR25## where G is as previously defined; and

L and R₁ are as defined for Equation 4.

The compound (l) and an alkyl isocyanate (e.g., n-butyl isocyanate) in xylene or other solvent boiling above 135° C. are mixed in the presence or absence of a catalytic amount of 1,4-diaza[2.2.2.]bicyclooctane (DABCO) and heated to 135° to 140° C. After 5 to 60 minutes phosgene is slowly added to the heated mixture at such rate that the temperature remains between 133° and 135° C. When the consumption of phosgene has ceased, the mixture is cooled and filtered to remove insoluble material. Finally, the solvent, alkyl isocyanate, and excess phosgene are evaporated, leaving the compound (6).

If desired, in many cases the alkyl isocyanate-sulfonimidamide or alkyl isocyanate-sulfonodiimidamide adduct can be made and isolated before reaction with the phosgene. In this case, the compound (1), alkyl isocyanate, and anhydrous base (e.g., K₂ CO₃) in a polar, aprotic solvent (e.g., acetone, butanone, or acetonitrile) are mixed and heated under reflux for 1 to 6 hours. The reaction mixture is then diluted with water, and the pH is adjusted to about 4 with acid (e.g., HCl, H₂ SO₄). The adduct is filtered out and dried, and then reacted with phosgene as described above. This procedure modification is especially useful when compound (1) is high melting and has low solubility in the phosgenation solvent.

Compounds (6) can also be prepared by the following method. ##STR26## where L, R₁ and G are as defined for Equation 14.

The compound (1) is heated at reflux in an excess of thionyl chloride. The reaction is continued until the amide protons are no longer detectable in the proton magnetic resonance spectrum. From 16 hours to 5 days is typically sufficient for complete conversion to the thionylamides (26) (Equation 15a)

The thionyl chloride is evaporated and the residue is treated with an inert solvent such as toluene containing at least one equivalent (typically 2-3 equivalents) of phosgene. A catalytic amount of pyridine (typically 0.1 equivalent) is added, and the mixture is heated to about 60° to 140° C., with 80° to 100° preferred. Conversion to the isocyanate (6) is usually substantially complete within 15 minutes to 3 hours (Equation 15b). The mixture is then cooled and filtered, and the solvent is evaporated, leaving compound (6).

Occasionally a compound (1) may not be of sufficient stability to be useful as a starting material in Equations 14 and 15. In this case as well as others, compound (6) can be made as an unisolated intermediate by treating the corresponding compound (7) with isocyanate anion in the presence of te heterocyclic amine (4). The amine reacts with compound (6) as it is formed to give the desired compound of Formula I (Equation 16). ##STR27## where L and R₁ are as defined for Equation 14; and

A, G and R are as previously defined.

The reaction is best carried out by adding over one to six hours a solution of at least one equivalent of a tetraalkylammonium isocyanate, such as tetra-n-butylammonium isocyanate, in a suitable aprotic organic solvent, such as dichloromethane or tetrahydrofuran, to a well-stirred mixture of one equivalent of compound (7) and at least one equivalent of heterocyclic amine (4) in a similar suitable organic solvent at 20° to 40° C. The reaction mixture is then diluted with dichloromethane, washed with 1N sulfuric acid, and dried over sodium sulfate. Rotary evaporation of the solvent leaves the product of Formula I in crude form. This can be purified as has already been described for Equation 4.

The heterocyclic amines of Formula (4a) to (4d) below are either known, disclosed in this application, or can be prepred by obvious methods by one skilled in the art. ##STR28##

For a review of the synthesis and reactions of 2-amino- and 2-methylaminopyrimidines (4a, Z=CH) see The Chemistry of Heterocyclic Compounds, Vol. 16, Wiley-Interscience, New York (1962). For a review of the synthesis and reactions of 2-amino- and 2-methylamino-s-triazines (4a, Z=N) see The Chemistry of Heterocyclic Compounds, Vol. 13, Wiley-Interscience, New York (1959), F. C. Schaefer, U.S. Pat. No. 3,154,537 and F. C. Schaefer and K. R. Huffman J. Org. Chem., 28, 1812 (1963). The synthesis of the bicyclic amines (4b) and (4c) is taught in U.S. Pat. No. 4,339,267. The synthesis of bicyclic amines (4d) is taught in European Patent Application (EP-A) 46,667.

Compounds of Formula (4e) are described in EP-A-73,562. Compounds of Formula (4f) are described in EP-A-94,260.

The amines of Formula (4g) can be prepared by methods taught in European Publication No. 125,864 (published 11/21/84) or by suitable modifications that would be obvious to one skilled in the art.

The amines of Formula (4) where X and X₁ is OCF₂ H and/or Y is OCF₂ H or SCF₂ H can be prepared by methods taught in South African Patent Application 825,045, or by suitable modifications that would be obvious to one skilled in the art.

The pyrimidines of Formula (4a) (Z=CH) where ##STR29## can be prepared according to the methods taught in European Patent Application (EP-A) 84,224 or suitable modifications thereof known to one skilled in the art.

The carbamate intermediates (2) are prepared by the following method. ##STR30## where A is as previously defined.

In this method, a solution or slurry of the appropriate heterocycle (4) in a suitable aprotic solvent (e.g., tetrahydrofuran, dioxane, glyme) at 0° to 30° C. is treated with two equivalents of sodium hydride. After gas evolution ceases, the reaction mixture is treated with one equivalent of dimethyl carbonate and stirred at 20° to 30° C. for 8 to 24 hours to provide a suspension of the sodium salt (27) (Equation 17a).

Sufficient concentrated hydrochloric acid is then added to bring the pH to 4. The mixture is saturated with sodium chloride and filtered. The organic layer is separated away from the aqueous layer, dried over magnesium sulfate, and filtered. Evaporation of the solvent leaves the heterocyclic carbamate (2, R=H) (Equation 17b).

Alternatively, the reaction mixture containing (27) formed in Equation 17a is treated with at least two equivalents of iodomethane and then heated at 60° to 80° C. for 8 to 24 hours. The mixture is cooled and filtered, and the solvent is evaporated. The residue is taken up in dichloromethane, washed with water, and the solvent is evaporated, leaving the N-methyl carbamate (2, R=CH₃) (Equation 17c).

In some cases, heterocycles of Formula (4) can be more easily prepared with R being H than with R being CH₃. Many heterocycles (4, R=CH₃) can be prepared from the corresponding heterocycles (4, R=H) by one or more of the following two methods. ##STR31## where A is as previously defined.

In this method, the carbamate (2, R=CH₃) prepared from (4, R=H) (Equations 17a and 17c) is dissolved in anhydrous, alcohol-free chloroform saturated with propylene gas. Slightly more than one equivalent (typically 1.1-1.2 equivalents) of iodotrimethylsilane is added and the stirred solution is heated at 50° to 60° C. for 2 to 4 hours. The mixture is cooled and two equivalents of methanol is added. The solvent is evaporated and the residue is taken up in methanol. The mixture is carefully neutralized with 10% sodium methoxide in methanol, and then the solvent is evaporated. The residue is triturated with ice-water. If a precipitate forms, it is filtered out, rinsed with ice-water and dried to provide (4, R=CH₃). If no precipitate forms, the solution is saturated with sodium chloride and extracted with ethyl acetate. Evaporation of the solvent leaves the heterocycle (4, R=CH₃).

Alternatively, the following two-step procedure is useful in many cases. ##STR32## where A is as previously defined.

A solution of the amine (4, R=H) in concentrated hydrochloric acid is treated with sodium nitrite solution and the chloro compound (28) is isolated in the usual manner by filtration of the acidic solution (Equation 19a). A representative procedure is described by Bee and Rose in J. Chem. Soc. C., 2031 (1966), for the case in which Z=CH, and X=Y=OCH₃.

The heterocycle (28) is then treated with at least two equivalents of methylamine in a suitable inert solvent (e.g., tetrahydrofuran, glyme, or diglyme) at a temperature between 20° and 80° C. for 1 to 18 hours (Equation 19b). The reaction mixture is then cooled and filtered. Evaporation of the solvent leaves (4, R=CH₃) contaminated with a little CH₃ NH₃ ⁺ Cl⁻ salt. The product can be purified by trituration with ice-water or by dissolution in dichloromethane, followed by washing with a small amount of water, drying, and evaporation of solvent. Further purification can be accomplished by recrystallization or column chromatography on silica gel.

Following is a typical reaction pathway for one specific compound of the invention: ##STR33##

The following examples further illustrate the synthesis of this invention.

EXAMPLE 1 S-2-Bromophenyl ethanethioate

A stirred solution of 2-bromothiophenol (100 g, 0.529 mol), acetic anhydride (62.4 mL, 0.661 mol), and 4-dimethylaminopyridine (3.2 g, 0.026 mol) in dichloromethane (1000 mL) was cooled in an ice-bath. Triethylamine (92.2 mL, 0.662 mol) was slowly added, and then the ice bath was removed. The mixture was stirred at room temperature for 1 hour. Water (10 mL) was added, and after a couple of minutes the mixture was washed with aqueous 1N hydrochloric acid (3×300 mL), 10% sodium hydroxide solution (3×300 mL), and 1N hydrochloric acid (300 mL), and then dried (Na₂ SO₄), and filtered. Evaporation of the solvent left S-2-bromophenyl ethanethioate as a pale yellow oil (104 g).

PMR (CDCl₃, 200 MHz): δ 7.70 (dd, 1H, Ar--H); 7.54 (dd, 1H, Ar--H); 7.36 (td, 1H, Ar--H); 7.27 (td, 1H, Ar--H); 2.46 (s, 3H, C(O)CH₃). IR (Neat): 1709 (vs, C=O) cm⁻¹.

EXAMPLE 2 2-Bromobenzenesulfonyl Chloride

A stirred mixture of S-2-bromophenyl ethanethioate (46.2 g, 0.200 mol) and acetic anhydride (20.4 g, 0.200 mol) was cooled to -10° C. Liquified chlorine (18.1 mL, 0.400 mol) was added at such a rate that the temperature remained below 5° C.; a dry ice-filled Dewar condenser was used to prevent the loss of the reagent. The mixture was warmed to room temperature and after 1.5 hours was briefly heated to 50° C. The acetyl chloride present was evaporated, and the residue was taken up in toluene. Evaporation of this solvent left 2-bromobenzenesulfonyl chloride as a pale orange yellow oil (49.7 g).

PMR (CDCl₃, 200 MHz): δ 8.14 (dd, 1H, Ar--H ortho to S(O)Cl); 7.66 (dd, 1H, Ar--H ortho to Br); 7.64 (td, 1H, Ar--H); 7.51 (td, 1H, ArH). The crude product was used in the next step without further characterization or purification.

EXAMPLE 3 2-Bromo-N-methylbenzenesulfinamide

Liquified methylamine (36.3 mL, 0.817 mol) was added slowly to a stirred solution of 2-bromobenzenesulfinyl chloride (48.9 g, 0.204 mol) in dichloromethane (489 mL) cooled below -70° C. The reaction mixture was allowed to warm to -10° C. and was then shaken with water (489 mL). The layers were separated, and the dichloromethane layer was washed with water (2×245 mL), dried (Na₂ SO₄), and filtered. Evaporation of the solvent left a pale yellow oil (44.4 g) that mostly crystallized on standing. This was dissolved in dichloromethane and chromatographed on a column of silica gel using 2:1 dichloromethane-ether as eluant. Fractions containing product (R_(f) =0.52, UV) were evaporated to leave 2-bromo-N-methylbenzenesulfinamide as a white crystalline solid (39.5 g) melting at 66°-70° C.

PMR (CDCl₃, 200 MHz): 67 7.98 (dd, 1H, Ar--H ortho to S(O)Cl); 7.61 (dd, 1H, Ar--H ortho to Br); 7.52 (td, 1H, Ar--H); 7.36 (td, 1H, Ar--H); 4.01 (broad s, 1H, NH); 2.57 (d, 3H, N--CH₃). IR (Nujol): 3200 (s, NH); 1040 (vs, multiple components, SO) cm⁻¹.

EXAMPLE 4 2-Bromo-N-(1,1-dimethylethyl)-N'-methylbenzenesulfonimidamide

A solution of 2-bromo-N-methylbenzenesulfinamide (2.34 g, 0.010 mol) and pyridine (0.81 mL, 0.010 mol) in dichloromethane (40 mL) was cooled below -70° C. Liquified chlorine (0.91 mL, 0.020 mol) was added dropwise. The reaction mixture was warmed to room temperature, and the solvent was evaporated leaving a white semisolid. This was mostly dissolved in dichloromethane (40 mL) and cooled below -70° C. Tert-butylamine (5.3 mL, 0.050 mol) was slowly added, and then the mixture was allowed to warm to room temperature. The solvent was evaporated, and the residue was dissolved in toluene and again evaporated. The residue was taken up in dichloromethane (ca. 60 mL), washed with saturated aqueous sodium hydrogen carbonate solution (3×25 mL), dried (Na₂ SO₄), and filtered. The solvent was evaporated, and the residue was taken up in toluene. Further evaporation afforded a yellow oil (3.0 g). This was dissolved in dichloromethane and chromatographed on a column of silica gel using 10:1 followed by 5:1 dichloromethane-ether as eluant. Fractions containing product (R_(f) =0.42, 10:1 CH₂ Cl₂ --Et₂ O, UV) were evaporated to yield 2-bromo-N-(1,1-dimethylethyl)-N'-methylbenzenesulfonimidamide as a pale yellow oil (1.9 g) that on standing formed a crystalline solid melting at 86°-87° C.

PMR (CDCl₃, 200 MHz): δ 8.23 (dd, 1H, Ar--H ortho to S(O)(NCH₃)(NH-t-Bu)); 7.68 (dd, 1H, Ar--H ortho to Br); 7.43 (td, 1H, Ar--H); 7.32 (td, 1H, Ar--H), 4.86 (broad s, 1H, NH); 2.57 (s, 3H, NCH₃); 1.31 (s, 9H, t-Bu). IR (Nujol): 3310 (m, NH), cm⁻¹.

EXAMPLE 5 2-Bromo-N'-methylbenzenesulfonimidamide

Cleavage of the tert-butyl group from 2-bromo-N-(1,1-dimethylethyl)-N'-methylbenzenesulfonimidamide by use of trifluoroacetic acid with or without added boron trifluoride etherate was found to be slow at room temperature. 2-Bromo-N-(1,1-dimethylethyl)-N'-methylbenzenesulfonimidamide (0.9 g, 2.9 mmol) recovered from these cleavage experiments and anisole (0.6 g, 5.5 mmol) were dissolved in trifluoroacetic acid (25 mL). Trifluoromethanesulfonic acid (ca. 9 g, 60 mmol) was added and the reaction mixture was stirred at room temperature for 1 hour. Then sodium acetate (5.5 g, 67 mmol) was added and the solvent was evaporated to leave a solid residue. This was dissolved in a mixture of dichloromethane and a small amount of water. Potassium carbonate was added until the mixture became basic. The mixture was partially dried (Na₂ SO₄), filtered through Celite®, redried (Na₂ SO₄), and gravity filtered. Evaporation of the solvent left a slightly brownish oil (1.4 g). This was dissolved in dichloromethane and chromatographed on a column of silica gel using 40:1 CH₂ Cl₂ --Et₂ O followed by 1:1 CH₂ Cl₂ --Et₂ O as eluant. Fractions containing the product (R_(f) =0.44, 10:1 CH₂ Cl₂ --Et₂ O, UV) were evaporated to leave 2-bromo-N'-methylbenzenesulfonimidamide as a colorless oil (0.7 g.).

PMR (CDCl₃, 200 MHz); δ 8.28 (dd, 1H, Ar--H ortho to S(O)NCH₃)(NH₂)); 7.74 (dd, 1H, Ar--H ortho to Br); 7.48 (td, 1H, Ar--H); 7.40 (td, 1H, Ar--H); 2.59 (s, 3H, NCH₃); 2.5-5.5 (extremely broad s, 2H, NH₂). IR (film): 3270 (s, broad, NH₂) cm⁻¹.

EXAMPLE 6 2-Bromo-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-N'-methylbenzenesulfonimidamide

1,8-Diazabicyclo[5.4.0]undec-7-ene (0.15 mL, 1.0 mmol) was added dropwise over one minute to a stirred solution of 2-bromo-N'-methylbenzenesulfonimidamide (0.25 g, 1.0 mmol) and phenyl (4,6-dimethoxypyrimidin-2-yl)carbamate (0.28 g, 1.0 mmol) in dry acetonitrile (5 mL) at room temperature. The solvent was evaporated, and the residue was dissolved in dichloromethane. Evaporation of this solvent left a pale yellow viscous oil (0.65 g). This was dissolved in CH₂ Cl₂, and acetic acid (57 μL, 1.0 mol) was added. This solution was chromatographed on a column of silica gel using 1:1 dichloromethane-ether as eluant. Fractions containing the product were diluted with toluene. The solvent was evaporated leaving an oil. This was dissolved in dichloromethane, and the solvent was evaporated leaving 2-bromo-N-(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl-N'-methylbenzenesulfonimidamide as a hard amorphous foam (0.45 g) melting at 120°-125° C.

PMR (CDCl₃, 200 MHz): δ ca. 7-15 (extremely broad s exchanging with H₂ O, 1H, S(O)(NCH₃)NHCO); 8.26 (dd, 1H, Ar--H ortho to S(O)(NCH₃)NHCO); 7.78 (broad s, 1H, CONH--Het); 7.76 (dd, 1H, Ar--H ortho to Br); 7.51 (td, 1H, Ar--H); 7.43 (td, 1H, Ar--H); 5.68 (s, 1H, Het 5-H); 3.88 (s, 6H, Het--OCH₃); 2.66 (s, 3H, NCH₃). Only a few very minor impurity peaks were present. IR (Nujol): ca. 3000 (w, very broad, NH); 1670 (s, C=O) cm⁻¹. Chemical ionization mass spectral analysis showed a molecular ion derived peak at m/e 430 (M+1) with a Br⁸¹ isotope satellite peak at m/e 432.

EXAMPLE 7 2-Chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-N'-methylbenzenesulfonimidamide

To a solution of 196.8 mg (0.96 mmol) of 2-chloro-N'-methylbenzenesulfonimidamide and 250 mg (0.96 mmol) of phenyl(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate in 5 mL of dry acetonitrile was added 0.15 mL (1.0 mmol) of 1,8-diazabicyclo[5.4.0]-undec-7-ene. After 45 minutes at room temperature, 5 mL of water and 2.5 mL of 5% HCl were added. The aqueous layer was extracted with methylene chloride (3×10 mL). The organic layer was dried (Na₂ SO₄), filtered and the solvent was removed with a rotary evaporator. The residue was triturated with ethyl acetate to give 80 mg of a white solid; m.p. 154° to 160° C.

¹ H NMR (d₆ -DMSO): δ 2.52 (s, 3H), 2.70 (s, 3H); 3.98 (s, 3H); 7.55 (m, 4H); 8.22 (d, 1H).

EXAMPLE 8 N-[(4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-2-(methylsulfonyl)benzenesulfonimidamide

To a solution of 62.6 mg (0.267 mmol) of 2-(methylsulfonyl)benzenesulfonimidamide and 73.5 mg (0.21 mmol) of phenyl(4,6-dimethoxypyrimidin-2-yl)carbamate in 1.3 mL of dry acetonitrile was added 0.04 mL (0.27 mmol) of 1,8-diazabicyclo[5.4.0]undec-7-ene. After 45 minutes at room temperature, 1.3 mL of water and 0.65 mL of 5% HCl were added. A solid precipitated out of solution. This material was isolated by filtration, washed with ether to give 60 mg of a white solid; m.p. 135° to 145° C. (d).

¹ H NMR (d₆ -DMSO): δ 3.48 (s, 3); 3.87 (s, 3); 5.90 (s, 1); 8.05 (m, 2); 8.28 (m, 2); 10.52 (brs, 1).

Using the procedures and examples shown above, one skilled in the art can prepare the compounds in Tables 1-32. ##STR34##

                                      TABLE 1                                      __________________________________________________________________________     General Structure 1                                                            R.sub.2        R.sub.3  R   X     Y       Z   m.p. (°C.)                __________________________________________________________________________     CH.sub.3       H        H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                   CH.sub.2 CH.sub.3                                                                             H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                    (CH.sub.2).sub.2 CH.sub.3                                                                     H        H   Cl    OCH.sub.3                                                                              CH                                   OCH.sub.3      H        H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                    OCH.sub.2 CH.sub.3                                                                            H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                    O(CH.sub.2).sub.2 CH.sub.3                                                                    H        H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                   Cl             H        H   Cl    OCH.sub.3                                                                              CH                                   Cl             6-Cl     H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                   NO.sub.2       H        H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                    CF.sub.3       H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                   CO.sub.2 CH.sub.3                                                                             H        H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                    CO.sub.2 CH.sub.3                                                                             H        CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                              N                                    CO.sub.2 CH.sub.3                                                                             3-CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                   CO.sub.2 CH.sub.3                                                                             5-CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                              CH                                   CO.sub.2 CH.sub.3                                                                             5-Cl     H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                    CO.sub.2 CH.sub.3                                                                             5-OCH.sub.3                                                                             H   OCH.sub.3                                                                            OCH.sub. 3                                                                             N                                    CO.sub.2 CH.sub.2 CH.sub.3                                                                    H        H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                   CO.sub.2 CH.sub.2 CH.sub.3                                                                    5-F      H   Cl    OCH.sub.3                                                                              CH                                   CO.sub.2 CH(CH.sub.3).sub.2                                                                   H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                   Br             H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH  160-165 (d)                      SO.sub.2 N(CH.sub.3).sub.2                                                                    H        H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                    SO.sub.2 N(CH.sub.3).sub.2                                                                    H        CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                   SO.sub.2 N(CH.sub.3).sub.2                                                                    5-Cl     H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                   SO.sub.2 N(OCH.sub.3)CH.sub.3                                                                 H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                    OSO.sub.2 CH.sub.3                                                                            H        H   Cl    OCH.sub.3                                                                              CH                                   OSO.sub.2 CH.sub.2 CH.sub.3                                                                   H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                    SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                            H        H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                   SO.sub.2 CH.sub.3                                                                             H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH  135-145 (d)                      SO.sub.2 CH.sub.2 CH.sub.3                                                                    H        H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                    OCHF.sub.2     H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                    5-methyl-1,3,4-oxadiazol-2-yl                                                                 H        H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                   5-methyl-1,3,4-oxadiazol-2-yl                                                                 H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                    1,2,3-thiadiazol-4-yl                                                                         H        H   CH.sub.3                                                                             OCH.sub. 3                                                                             N                                    1,2,3-thiadiazol-4-yl                                                                         H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                   CO.sub.2 CH.sub.2 CH═CH.sub.2                                                             H        H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                   Cl             H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH  157-162 (d)                      Cl             H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              N   103-106                          Cl             H        H   CH.sub.3                                                                             OCH.sub.3                                                                              N   235-240 (d)                      Cl             H        H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                   SO.sub.2 CH.sub.3                                                                             H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              N   195-202 (d)                      SO.sub.2 CH.sub.3                                                                             H        H   CH.sub.3                                                                             OCH.sub.3                                                                              N   158-161                          SCH.sub.3      H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH  168-172                          OCHFCHF.sub.2  H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                    SCF.sub.3      5-Cl     H   CH.sub.3                                                                             CH.sub.3                                                                               CH                                   SCH.sub.2 CCl.sub.3                                                                           H        H   OCH.sub.3                                                                            CH.sub.3                                                                               N                                    SO.sub.2 CH.sub.2 CH.sub.2 Br                                                                 H        H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                   COCH.sub.2 CH.sub.3                                                                           5-SCH.sub.3                                                                             H   CH.sub.3                                                                             CH.sub.3                                                                               CH                                   S(O)CH.sub.3   H        H   Cl    OCH.sub.3                                                                              CH                                   CH.sub.2 OCF.sub.3                                                                            H        H   Cl    OCH.sub.3                                                                              CH                                   2-methyl-isoxazol-4-yl                                                                        H        H   OCH.sub.3                                                                            CH.sub.3                                                                               N                                    2-methyl-isothiazol-4-yl                                                                      H        H   CH.sub.3                                                                             CH.sub.3                                                                               CH                                   isothiazol-5-yl                                                                               H        CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                              N                                    5-methyl-isothiazol-2-yl                                                                      H        H   Cl    OCH.sub.3                                                                              CH                                   CO.sub.2 CH.sub.3                                                                             5-CH.sub.2 CH.sub.3                                                                     H   OCH.sub.3                                                                            CH.sub.3                                                                               CH                                   CO.sub.2 CH.sub.3                                                                             5-CH.sub.2 OCH.sub.3                                                                    H   CH.sub.3                                                                             CH.sub.3                                                                               CH                                   Cl             6-SCH.sub.3                                                                             H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                   CO.sub.2 CH.sub.3                                                                             H        H   OCH.sub.3                                                                            CH.sub.2 S(O)CH.sub.3                                                                  CH                                   SO.sub.2 N(CH.sub.3).sub.2                                                                    5-OCF.sub.3                                                                             H   CH.sub.3                                                                             CH.sub.3                                                                               CH                                   Cl             5-CH.sub.2 SCH.sub.3                                                                    H   Cl    OCH.sub.3                                                                              CH                                   Cl             5-OCH.sub.2 CHF.sub.2                                                                   H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                    Cl             H        H   OCF.sub.2 H                                                                          NH.sub.2                                                                               CH                                   Cl             H        H   OCH.sub.3                                                                            CH.sub.2 SO.sub.2 CH.sub.3                                                             N                                    Cl             H        H   OCH.sub.3                                                                            C.tbd.CH                                                                               N                                    Cl             H        H   OCH.sub.3                                                                            C.tbd.CCH.sub.3                                                                        N                                    __________________________________________________________________________

                                      TABLE 2                                      __________________________________________________________________________     General Structure 2                                                            R.sub.2        R.sub.3                                                                              R   X    Y    Z   m.p. (°C.)                       __________________________________________________________________________     CH.sub.3       H     H   CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          CH.sub.2 CH.sub.3                                                                             H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           (CH.sub.2).sub.2 CH.sub.3                                                                     H     H   Cl   OCH.sub.3                                                                           CH                                          OCH.sub.3      H     H   CH.sub.3                                                                            OCH.sub.3                                                                           N                                           OCH.sub.2 CH.sub.3                                                                            H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           O(CH.sub.2).sub.2 CH.sub.3                                                                    H     H   CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          Cl             H     H   Cl   OCH.sub.3                                                                           CH  156-159                                 Cl             6-Cl  H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          NO.sub.2       H     H   CH.sub.3                                                                            OCH.sub.3                                                                           N                                           CF.sub.3       H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          CO.sub.2 CH.sub.3                                                                             H     H   CH.sub.3                                                                            OCH.sub.3                                                                           N                                           CO.sub.2 CH.sub.3                                                                             H     CH.sub.3                                                                           CH.sub.3                                                                            OCH.sub.3                                                                           N                                           CO.sub.2 CH.sub.3                                                                             3-CH.sub.3                                                                           H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          CO.sub.2 CH.sub.3                                                                             5-CH.sub.3                                                                           H   Cl   OCH.sub.3                                                                           CH                                          CO.sub.2 CH.sub.3                                                                             5-Cl  H   CH.sub.3                                                                            OCH.sub.3                                                                           N                                           CO.sub.2 CH.sub.3                                                                             5-OCH.sub.3                                                                          H   OCH.sub. 3                                                                          OCH.sub.3                                                                           N                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                    H     H   CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          CO.sub.2 CH.sub.2 CH.sub.3                                                                    5-F   H   Cl   OCH.sub.3                                                                           CH                                          CO.sub.2 CH(CH.sub.3).sub.2                                                                   H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          Br             H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH  120-125 (Amorphous)                     SO.sub.2 N(CH.sub.3).sub.2                                                                    H     H   CH.sub.3                                                                            OCH.sub.3                                                                           N                                           SO.sub.2 N(CH.sub.3).sub.2                                                                    H     CH.sub.3                                                                           OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          SO.sub.2 N(CH.sub.3).sub.2                                                                    5-Cl  H   CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          SO.sub.2 N(OCH.sub.3)CH.sub.3                                                                 H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           OSO.sub.2 CH.sub.3                                                                            H     H   Cl   OCH.sub.3                                                                           CH                                          OSO.sub.2 CH.sub.2 CH.sub.3                                                                   H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                            H     H   CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          SO.sub.2 CH.sub.3                                                                             H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          SO.sub.2 CH.sub.2 CH.sub.3                                                                    H     H   CH.sub.3                                                                            OCH.sub.3                                                                           N                                           OCHF.sub.2     H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           5-methyl-1,3,4-oxadiazol-2-yl                                                                 H     H   CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          5-methyl-1,3,4-oxadiazol-2-yl                                                                 H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           1,2,3-thiadiazol-4-yl                                                                         H     H   CH.sub.3                                                                            OCH.sub.3                                                                           N                                           1,2,3-thiadiazol-4-yl                                                                         H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          CO.sub.2 CH.sub.2 CH═CH.sub.2                                                             H     H   CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          Cl             H     H   CH.sub.3                                                                            OCH.sub.3                                                                           N   154-160                                 Cl             H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           N   181-187                                 Cl             H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH  150-157                                 Cl             6-OCHF.sub.2                                                                         H   CH.sub.3                                                                            CH.sub.3                                                                            CH                                          SCCl.sub.3     H     H   OCH.sub.3                                                                           CH.sub.3                                                                            N                                           SCH.sub.3      H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          COCH.sub.3     5-Cl  H   CH.sub.3                                                                            OCH.sub.3                                                                           N                                           CH.sub.2 OCF.sub.3                                                                            5-OCF.sub.3                                                                          H   Cl   OCH.sub.3                                                                           CH                                          2-methyl-isoxazoyl-4-yl                                                                       H     H   OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           __________________________________________________________________________

                                      TABLE 3                                      __________________________________________________________________________     General Structure 3                                                            R.sub.2        R.sub.3 R   X     Y       Z m.p. (°C.)                   __________________________________________________________________________     CH.sub.3       H       H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                    CH.sub.2 CH.sub.3                                                                             H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     (CH.sub.2).sub.2 CH.sub.3                                                                     H       H   Cl    OCH.sub.3                                                                              CH                                    OCH.sub.3      H       H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                     OCH.sub.2 CH.sub.3                                                                            H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     O(CH.sub.2).sub.2 CH.sub.3                                                                    H       H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                    Cl             H       H   Cl    OCH.sub.3                                                                              CH                                    Cl             6-Cl    H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    NO.sub.2       H       H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                     CF.sub.3       H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    CO.sub.2 CH.sub.3                                                                             H       H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                     CO.sub.2 CH.sub.3                                                                             H       CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                              N                                     CO.sub.2 CH.sub.3                                                                             3-CH.sub.3                                                                             H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    CO.sub.2 CH.sub.3                                                                             5-CH.sub.3                                                                             H   Cl    OCH.sub.3                                                                              CH                                    CO.sub.2 CH.sub.3                                                                             5-Cl    H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                     CO.sub.2 CH.sub.3                                                                             5-OCH.sub.3                                                                            H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     CO.sub. 2 CH.sub.2 CH.sub.3                                                                   H       H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                    CO.sub.2 CH.sub.2 CH.sub.3                                                                    5-F     H   Cl    OCH.sub.3                                                                              CH                                    CO.sub.2 CH(CH.sub.3).sub.2                                                                   H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    Br             H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    SO.sub.2 N(CH.sub.3).sub.2                                                                    H       H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                     SO.sub.2 N(CH.sub.3).sub.2                                                                    H       CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    SO.sub.2 N(CH.sub.3).sub.2                                                                    5-Cl    H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                    SO.sub.2 N(OCH.sub.3)CH.sub.3                                                                 H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     OSO.sub.2 CH.sub.3                                                                            H       H   Cl    OCH.sub.3                                                                              CH                                    OSO.sub.2 CH.sub.2 CH.sub.3                                                                   H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                            H       H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                    SO.sub.2 CH.sub.3                                                                             H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    SO.sub.2 CH.sub.2 CH.sub.3                                                                    H       H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                     OCHF.sub.2     H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     5-methyl-1,3,4-oxadiazol-2-yl                                                                 H       H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                    5-methyl-1,3,4-oxadiazol-2-yl                                                                 H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     1,2,3-thiadiazol-4-yl                                                                         H       H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                     1,2,3-thiadiazol-4-yl                                                                         H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    CO.sub.2 CH.sub.2 CH═CH.sub.2                                                             H       H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                    Cl             H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    Cl             H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     Cl             H       H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                     Cl             H       H   CH.sub.3                                                                             OCH.sub.3                                                                              CH                                    SO.sub.2 CH.sub.3                                                                             H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     SO.sub.2 CH.sub.3                                                                             H       H   CH.sub.3                                                                             OCH.sub.3                                                                              N                                     SCH.sub.3      H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    OCHFCHF.sub.2  H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     SCF.sub.3      5-Cl    H   CH.sub.3                                                                             CH.sub.3                                                                               CH                                    SCH.sub.2 CCl.sub.3                                                                           H       H   OCH.sub.3                                                                            CH.sub.3                                                                               N                                     SO.sub.2 CH.sub.2 CH.sub.2 Br                                                                 H       H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    COCH.sub.2 CH.sub.3                                                                           5-SCH.sub.3                                                                            H   CH.sub.3                                                                             CH.sub.3                                                                               CH                                    S(O)CH.sub.3   H       H   Cl    OCH.sub.3                                                                              CH                                    CH.sub.2 OCF.sub.3                                                                            H       H   Cl    OCH.sub.3                                                                              CH                                    2-methyl-isoxazol-4-yl                                                                        H       H   OCH.sub.3                                                                            CH.sub.3                                                                               N                                     2-methyl-isothiazol-4-yl                                                                      H       H   CH.sub.3                                                                             CH.sub.3                                                                               CH                                    isothiazol-5-yl                                                                               H       CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     5-methyl-isothiazol-2-yl                                                                      H       H   Cl    OCH.sub.3                                                                              CH                                    CO.sub.2 CH.sub.3                                                                             5-CH.sub.2 CH.sub.3                                                                    H   OCH.sub.3                                                                            CH.sub.3                                                                               CH                                    CO.sub.2 CH.sub. 3                                                                            5-CH.sub.2 OCH.sub.3                                                                   H   CH.sub.3                                                                             CH.sub.3                                                                               CH                                    Cl             6-SCH.sub.3                                                                            H   OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                    CO.sub.2 CH.sub.3                                                                             H       H   OCH.sub.3                                                                            CH.sub.2 S(O)CH.sub.3                                                                  CH                                    SO.sub.2 N(CH.sub.3).sub.2                                                                    5-OCF.sub.3                                                                            H   CH.sub.3                                                                             CH.sub.3                                                                               CH                                    Cl             5-CH.sub.2 SCH.sub.3                                                                   H   Cl    OCH.sub.3                                                                              CH                                    Cl             5-OCH.sub.2 CHF.sub.2                                                                  H   OCH.sub.3                                                                            OCH.sub.3                                                                              N                                     Cl             H       H   OCF.sub.2 H                                                                          NH.sub.2                                                                               CH                                    Cl             H       H   OCH.sub.3                                                                            CH.sub.2 SO.sub.2 CH.sub.3                                                             N                                     Cl             H       H   OCH.sub.3                                                                            C.tbd.CH                                                                               N                                     Cl             H       H   OCH.sub.3                                                                            C.tbd.CCH.sub.3                                                                        N                                     __________________________________________________________________________

                                      TABLE 4                                      __________________________________________________________________________     General Structure 4                                                            R.sub.2   R.sub.3                                                                               R  X    Y      Z  m.p. (°C.)                           __________________________________________________________________________     CH.sub.3  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              (CH.sub.2).sub.2 CH.sub.3                                                                H      H  Cl   OCH.sub.3                                                                             CH                                             OCH.sub.3 H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              O(CH.sub.2).sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  Cl   OCH.sub.3                                                                             CH                                             Cl        6-Cl   H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             NO.sub.2  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CF.sub.3  H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        3-CH.sub.3                                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        5-OCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                               5-F    H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH(CH.sub.3).sub.2                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Br        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 N(OCH.sub.3)CH.sub.3                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              OSO.sub.2 CH.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             OSO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                       H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCHF.sub.2                                                                               H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-1,3,4-                                                                          H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             oxadiazol-2-yl                                                                 5-methyl-1,3,4-                                                                          H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              oxadiazol-2-yl                                                                 1,2,3-thiadiazol-                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              4-yl                                                                           1,2,3-thiadiazol-                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             4-yl                                                                           CO.sub.2 CH.sub.2 CH═CH.sub.2                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SCH.sub.3 H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             OCHFCHF.sub.2                                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SCF.sub.3 5-Cl   H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             SCH.sub.2 CCl.sub.3                                                                      H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              SO.sub.2 CH.sub.2 CH.sub.2 Br                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             COCH.sub.2 CH.sub.3                                                                      5-SCH.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             S(O)CH.sub.3                                                                             H      H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.2 OCF.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             2-methyl-isoxa-                                                                          H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              zol-4-yl  3                                                                    2-methyl-iso-                                                                            H      H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             thiazol-4-yl                                                                   isothiazol-5-yl                                                                          H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-iso-                                                                            H      H  Cl   OCH.sub.3                                                                             CH                                             thiazol-2-yl                                                                   CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 CH.sub.3                                                                   H  OCH.sub.3                                                                           CH.sub.3                                                                              CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 OCH.sub.3                                                                  H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        6-SCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           CH.sub.2 S(O)CH.sub.3                                                                 CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-OCF.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        5-CH.sub.2 SCH.sub.3                                                                  H  Cl   OCH.sub.3                                                                             CH                                             Cl        5-OCH.sub.2 CHF.sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  OCF.sub.2 H                                                                         NH.sub.2                                                                              CH                                             Cl        H      H  OCH.sub.3                                                                           CH.sub.2 SO.sub.2 CH.sub.3                                                            N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CH                                                                              N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CCH.sub.3                                                                       N                                              __________________________________________________________________________

                                      TABLE 5                                      __________________________________________________________________________     General Structure 5                                                            R.sub.2   R.sub.3                                                                               R  X    Y      Z  m.p. (°C.)                           __________________________________________________________________________     CH.sub.3  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              (CH.sub.2).sub.2 CH.sub.3                                                                H      H  Cl   OCH.sub.3                                                                             CH                                             OCH.sub.3 H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              O(CH.sub.2).sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  Cl   OCH.sub.3                                                                             CH                                             Cl        6-Cl   H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             NO.sub.2  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CF.sub.3  H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        3-CH.sub.3                                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        5-OCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                               5-F    H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH(CH.sub.3).sub.2                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Br        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 N(OCH.sub.3)CH.sub.3                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              OSO.sub.2 CH.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             OSO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                       H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCHF.sub.2                                                                               H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-1,3,4-                                                                          H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             oxadiazol-2-yl                                                                 5-methyl-1,3,4-                                                                          H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              oxadiazol-2-yl                                                                 1,2,3-thiadiazol-                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              4-yl                                                                           1,2,3-thiadiazol-                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             4-yl                                                                           CO.sub.2 CH.sub.2 CH═CH.sub.2                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SCH.sub.3 H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             OCHFCHF.sub.2                                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SCF.sub.3 5-Cl   H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             SCH.sub.2 CCl.sub.3                                                                      H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              SO.sub.2 CH.sub.2 CH.sub.2 Br                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             COCH.sub.2 CH.sub.3                                                                      5-SCH.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             S(O)CH.sub.3                                                                             H      H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.2 OCF.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             2-methyl-isoxa-                                                                          H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              zol-4-yl                                                                       2-methyl-iso-                                                                            H      H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             thiazol-4-yl                                                                   isothiazol-5-yl                                                                          H      CH.sub. 3                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-iso-                                                                            H      H  Cl   OCH.sub.3                                                                             CH                                             thiazol-2-yl                                                                   CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 CH.sub.3                                                                   H  OCH.sub.3                                                                           CH.sub.3                                                                              CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 OCH.sub.3                                                                  H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        6-SCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           CH.sub.2 S(O)CH.sub.3                                                                 CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-OCF.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        5-CH.sub.2 SCH.sub.3                                                                  H  Cl   OCH.sub.3                                                                             CH                                             Cl        5-OCH.sub.2 CHF.sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  OCF.sub.2 H                                                                         NH.sub.2                                                                              CH                                             Cl        H      H  OCH.sub.3                                                                           CH.sub.2 SO.sub.2 CH.sub.3                                                            N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CH                                                                              N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CCH.sub.3                                                                       N                                              __________________________________________________________________________

                                      TABLE 6                                      __________________________________________________________________________     General Structure 6                                                            R.sub.1   R.sub.2       R.sub.3                                                                             R  X      Y              Z  m.p.                  __________________________________________________________________________                                                              (°C.)          (CH.sub.2).sub.2 CH.sub.3                                                                SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              OCH.sub.3      CH                       CH.sub.2 CH.sub.2 F                                                                      CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.2 CH.sub.2 F                                                                      SO.sub.2 CH.sub.3                                                                            H    H  Cl     OCH.sub.3      CH                       CH.sub.2 CH.sub.2 CH.sub.2 F                                                             SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.2 CH.sub.2 CH.sub.2 F                                                             CO.sub.2 CH.sub.2 CH.sub.3                                                                   H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.2 CH.sub.2 CF.sub.3                                                               SO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              OCH.sub.3      CH                       CH.sub.2 CHFCH.sub.2 F                                                                   SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.2 CH.sub.2 OCH.sub.3                                                              CO.sub.2 CH.sub.3                                                                            H    H  Cl     OCH.sub.3      CH                       CH.sub.2 CH.sub.2 OH                                                                     SO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.2 CH.sub.2 OSi(CH.sub.3 ).sub.3                                                   SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.3                                                                             OCH.sub.3      N                        OH        SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              OCH.sub.3      CH                       OSi(CH.sub.3).sub.3                                                                      CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       OCH.sub.3 SO.sub.2 CH.sub.3                                                                            H    H  Cl     OCH.sub.3      CH                       OCH.sub.2 CH.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              OCH.sub.3      N                        SO.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             OCH.sub.3      N                        C.sub.6 H.sub.5                                                                          SO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              OCH.sub.3      CH                       CH.sub.2 C.sub.6 H.sub.5                                                                 SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       OCH.sub.3 CO.sub.2 CH.sub.3                                                                            H    CH.sub.3                                                                          CH.sub.3                                                                              OCH.sub.3      CH                       SO.sub.2 CH.sub.3                                                                        SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.2 C.sub.6 H.sub.5                                                                 CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             OCH.sub.3      N                        OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              CH.sub.3       CH                       SO.sub.2 CH.sub.3                                                                        SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             N(CH.sub.3).sub.2                                                                             N                        CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                                    H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         (CH.sub.2).sub.3 CH.sub.3                                                                    H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  O(CH.sub.2).sub.3 CH.sub.3                                                                   H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         O(CH.sub.2).sub.3 CH.sub.3                                                                   H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  OCH.sub.2 CH.sub.2 OCH.sub.3                                                                 H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         OCH.sub.2 CH.sub.2 OCH.sub.3                                                                 H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  F             H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         F             H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                           H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                           H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                         H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                         H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  CO.sub.2 CH.sub.2 CH.sub. 2 Cl                                                               H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                                H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  OCF.sub.3     H    H  OCH.sub.3                                                                             OCH.sub.3      N                        H         OCF.sub.3     H    H  CH.sub.3                                                                              OCH.sub.3      CH                       CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                          H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       H         SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                          H    H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                                H    H  OCH.sub.3                                                                             OCH.sub.3      N                        H         SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                                H    H  CH.sub.3                                                                              OCH.sub.3      CH                       CH.sub.3  OSO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         OSO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  OSO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         OSO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                          H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                            H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         SO.sub.2 CH.sub.2 CH═CH.sub.2                                                            H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  SCF.sub.3     H    H  OCH.sub.3                                                                             OCH.sub.3      N                        H         SCF.sub.3     H    H  CH.sub.3                                                                              OCH.sub.3      CH                       CH.sub.3  SO.sub.2 CF.sub.3                                                                            H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         SO.sub.2 CF.sub.3                                                                            H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  SCF.sub.2 H   H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         SCF.sub.2 H   H    H  Cl     OCH.sub.3      CH                       CH.sub.3  SO.sub.2 CF.sub.2 H                                                                          H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       H         SO.sub.2 CF.sub.2 H                                                                          H    H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.3  OCH.sub.2 CH═CH.sub.2                                                                    H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         OCH.sub.2 CH═CH.sub.2                                                                    H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  OCH.sub.2 CH═CHCH.sub.3                                                                  H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         OCH.sub.2 CH═CHCH.sub.3                                                                  H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  OCH.sub.2 C.tbd.CH                                                                           H    H  OCH.sub.3                                                                             OCH.sub.3      N                        H         OCH.sub.2 C.tbd.CH                                                                           H    H  CH.sub.3                                                                              OCH.sub.3      CH                       CH.sub.3  OCH.sub.2 C.tbd.CCH.sub.3                                                                    H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       H         OCH.sub.2 C.tbd.CCH.sub.3                                                                    H    H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.3  CH.sub.2 OCH.sub.3                                                                           H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         CH.sub.2 OCH.sub.3                                                                           H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  CH.sub.2 OCH.sub.2 CH.sub.3                                                                  H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         CH.sub.2 OCH.sub.2 CH.sub.3                                                                  H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  (CH.sub.2).sub.2 OCH.sub.3                                                                   H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         (CH.sub.2).sub.2 OCH.sub.3                                                                   H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                          H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                          H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  C.sub.6 H.sub.5                                                                              H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         C.sub.6 H.sub.5                                                                              H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  1,3,4,oxadiazol-2-yl                                                                         H    H  OCH.sub.3                                                                             OCH.sub.3      N                        H         1,3,4-oxadiazol-2-yl                                                                         H    H  CH.sub.3                                                                              OCH.sub.3      CH                       CH.sub.3  5-isoxazolyl  H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       H         5-isoxazolyl  H    H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.3  3-isoxazolyl  H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         3-isoxazolyl  H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  4-isoxazolyl  H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         4-isoxazolyl  H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  1-methyl-1H--pyrazol-3-yl                                                                    H    H  OCH.sub.3                                                                             OCH.sub.3      N                        H         1-methyl-1H--pyrazol-3-yl                                                                    H    H  CH.sub.3                                                                              OCH.sub.3      CH                       CH.sub.3  1H--pyrazol-1-yl                                                                             H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       H         1H--pyrazol-1-yl                                                                             H    H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.3  1H--1,2,4-triazol-1-yl                                                                       H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         1H--1,2,4-triazol-1-yl                                                                       H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  tetrahydro-2-furanyl                                                                         H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         tetrahydro-2-furanyl                                                                         H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  2-furanyl     H    H  CH.sub.3                                                                              OCH.sub.3      N                        H         2-furanyl     H    H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  2-thienyl     H    H  CH.sub.3                                                                              OCH.sub.3      CH                       H         2-thienyl     H    H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub. 3 SO.sub.2 N(CH.sub.3).sub.2                                                                   5-F  H  CH.sub.3                                                                              OCH.sub.3      N                        H         CO.sub.2 CH.sub.3                                                                            3-F  H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            3-Cl H  OCH.sub.3                                                                             OCH.sub.3      CH                       H         OCF.sub.2 H   6-Cl H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.3  SO.sub.2 CH.sub.3                                                                            6-Br H  CH.sub.3                                                                              OCH.sub.3      N                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                   5-Br H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                   5-CF.sub.3                                                                          H  OCH.sub.3                                                                             OCH.sub.3      CH                       H         Cl            6-CF.sub.3                                                                          H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.3  OSO.sub.2 CH.sub.3                                                                           6-CH.sub.3                                                                          H  OCH.sub.3                                                                             OCH.sub.3      N                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                   5-CH.sub.3                                                                          H  CH.sub.3                                                                              OCH.sub.3      CH                       CH.sub.3  SO.sub.2 CH.sub.3                                                                            3-OCH.sub.3                                                                         H  OCH.sub.3                                                                             OCH.sub.3      CH                       H         CO.sub.2 CH.sub.3                                                                            5-OCH.sub.3                                                                         H  CH.sub.3                                                                              OCH.sub.3      N                        CH.sub.3  SO.sub.2 CH.sub.3                                                                            6-OCF.sub.2 H                                                                       H  CH.sub.3                                                                              OCH.sub.3      N                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                   5-OCF.sub.2 H                                                                       H  OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            5-OC.sub.2 H.sub.5                                                                  H  CH.sub.3                                                                              OCH.sub.3      CH                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                   6-OC.sub.2 H.sub.5                                                                  H  OCH.sub.3                                                                             OCH.sub.3      N                        CH.sub.3  OCH.sub.2 CH.sub.3                                                                           6-Cl CH.sub.3                                                                          CH.sub.3                                                                              OCH.sub.3      N                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                   5-OCH.sub.3                                                                         CH.sub.3                                                                          OCH.sub.3                                                                             OCH.sub.3      CH                       CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                   H    H  CH.sub.3                                                                              CH.sub.3       CH                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.3                                                                             OC.sub.2 H.sub.5                                                                              N                        CH.sub.3  SO.sub.2 CH.sub.3                                                                            H    H  OC.sub.2 H.sub.5                                                                      CH.sub.3       N                        H         OSO.sub.2 CH.sub.3                                                                           H    H  OC.sub.2 H.sub.5                                                                      OC.sub.2 H.sub.5                                                                              CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  Cl     OCH.sub.3      CH                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  Cl     OC.sub.2 H.sub.5                                                                              CH                       CH.sub.3  SO.sub.2 CH.sub.3                                                                            H    H  F      OCH.sub.3      CH                       H         SO.sub.2 N(OCH.sub.3)CH.sub.3                                                                H    H  F      OCH.sub.3      CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  Br     OCH.sub.3      CH                       H         OSO.sub.2 CH.sub.3                                                                           H    H  Br     OCH.sub.3      CH                       CH.sub.3  NO.sub.2      H    H  I      OCH.sub.3      CH                       H         CO.sub.2 CH.sub.3                                                                            H    H  I      OCH.sub.3      CH                       CH.sub.3  SO.sub.2 CH.sub.3                                                                            H    H  OCF.sub.2 H                                                                           CH.sub.3       CH                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCF.sub.2 H                                                                           OCF.sub.2 H    CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  CH.sub.2 F                                                                            CH.sub.3       N                        H         Cl            6-Cl H  CH.sub.2 F                                                                            OCH.sub.3      CH                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.2 CH.sub.2 F                                                                  OCH.sub.3      CH                       H         SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.2 CH.sub.2 F                                                                  CH.sub.3       N                        CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                   H    H  OCH.sub.2 CHF.sub.2                                                                   CH.sub.3       N                        H         NO.sub.2      H    H  OCH.sub.2 CHF.sub.2                                                                   OCH.sub.3      CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.2 CF.sub.3                                                                    OCH.sub.3      CH                       H         OSO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.2 CF.sub.3                                                                    CH.sub.3       N                        CH.sub.3  SO.sub.2 CH.sub. 3                                                                           H    H  CF.sub.3                                                                              CH.sub.3       CH                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CF.sub.3                                                                              OCH.sub.3      CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             H              CH                       CH.sub.3  NO.sub.2      H    H  CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                              N                        CH.sub.3  OSO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                            N                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                            CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              CH.sub.2 OCH.sub.2 CH.sub.3                                                                   CH                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.3                                                                             CH.sub.2 OCH.sub.2 CH.sub.3                                                                   N                        CH.sub.3  SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             NHCH.sub.3     N                        H         OSO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                             NHCH.sub.3     CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             N(OCH.sub.3)CH.sub.3                                                                          N                        H         SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             N(CH.sub.3).sub.2                                                                             N                        CH.sub.3  NO.sub.2      H    H  OCH.sub.3                                                                             N(CH.sub.3).sub.2                                                                             CH                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              C.sub.2 H.sub.5                                                                               CH                       CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                   H    H  OCH.sub.3                                                                             C.sub.2 H.sub.5                                                                               N                        H         SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             CF.sub.3       N                        CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              CF.sub.3       CH                       H         OSO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                              SCH.sub.3      CH                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.3                                                                             SCH.sub.3      N                        H         CO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              OCH.sub.2 C.tbd.CH                                                                            N                        CH.sub.3  SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             OCH.sub.2 C.tbd.CH                                                                            CH                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.3                                                                             OCH.sub.2 CH═CH.sub.2                                                                     CH                       CH.sub.3  NO.sub.2      H    H  CH.sub.3                                                                              OCH.sub.2 CH═CH.sub.2                                                                     N                        H         OSO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                             OCH.sub.2 CH.sub.2 OCH.sub.3                                                                  N                        CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              OCH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH                       H         SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                            CH                       CH.sub.3  NO.sub.2      H    H  OCH.sub.3                                                                             CH.sub.2 SCH.sub.3                                                                            N                        CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              OCF.sub.2 H    CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             SCF.sub.2 H    CH                       H         SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             SCF.sub.2 H    N                        CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             cyclopropyl    N                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.3                                                                             cyclopropyl    CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             dimethoxymethyl                                                                               N                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              dimethoxymethyl                                                                               CH                       CH.sub.3  SO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              ethoxymethoxymethyl                                                                           CH                       H         NO.sub.2      H    H  OCH.sub.3                                                                             ethoxymethoxymethyl                                                                           CH                       CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                   H    H  CH.sub.3                                                                              diethoxymethyl CH                       H         OSO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                             diethoxymethyl CH                       CH.sub.3  SO.sub.2 CH.sub.2                                                                            H    H  OCH.sub.3                                                                             1,1-dimethoxyethyl                                                                            CH                       H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              1,1-dimethoxyethyl                                                                            CH                       CH.sub.3  OSO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                              methoxy(methylthio)methyl                                                                     CH                       H         CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             methoxy(methylthio)methyl                                                                     CH                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.3                                                                             bis(methylthio)methyl                                                                         CH                       H         SO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              bis(methylthio)methyl                                                                         CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              1,3-dioxolan-2-yl                                                                             CH                       H         SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             1,3,dioxolan-2-yl                                                                             N                        CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              2-methyl-1,3-  CH                                                              dioxolan-2-yl                           H         NO.sub.2      H    H  OCH.sub.3                                                                             2-methyl-1,3-  CH                                                              dioxolan-2-yl                           CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             1,3-dioxan-2-yl                                                                               CH                       H         OSO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                              1,3-dioxan-2-yl                                                                               CH                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              1,3-oxathiolan-2-yl                                                                           CH                       H         SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             1,3-oxathiolan-2-yl                                                                           CH                       CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  OCH    1,3-dithiolan-2-yl                                                                            CH                       H         OSO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                              1,3-dithiolan-2-yl                                                                            CH                       CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  CH.sub.3                                                                              4-methyl-1,3-  CH                                                              dioxolan-2-yl                           H         OSO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                             4-methyl-1,3-  CH                                                              dioxolan-2-yl                           CH.sub.3  NO.sub.2      H    H  OCH.sub.3                                                                             2,4-dimethyl-1,3-                                                                             CH                                                              dioxolan-2-yl                           H         CO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              2,4-dimethyl-1,3-                                                                             CH                                                              dioxolan-2-yl                           CH.sub.3  OSO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                              5-methyl-1,3-  CH                                                              oxathiolan-2-yl                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                   H    H  OCH.sub.3                                                                             5-methyl-1,3-  CH                                                              oxathiolan-2-yl                         CH.sub.3  SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             4-methyl-1,3-  CH                                                              oxathiolan-2-yl                         H         NO.sub.2      H    H  CH.sub.3                                                                              4-methyl-1,3-  CH                                                              oxathiolan-2-yl                         CH.sub.3  CO.sub.2 CH.sub.3                                                                            H    H  CH.sub.3                                                                              4-methyl-1,3-  CH                                                              dithiolan-2-yl                          H         SO.sub.2 CH.sub.3                                                                            H    H  OCH.sub.3                                                                             4-methyl-1,3-  CH                                                              dithiolan-2-yl                          __________________________________________________________________________

                                      TABLE 7                                      __________________________________________________________________________     General Structure 7                                                            R.sub.1   R.sub.4                                                                               R  X    Y      Z  m.p. (°C.)                           __________________________________________________________________________     H         Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             H         Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             H         Cl     H  Cl   OCH.sub.3                                                                             CH                                             H         Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              H         Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              H         Cl     CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.3  Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.3  Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CH.sub.3  Cl     H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.3  Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CH.sub.3  Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              CH.sub.2 CH.sub.3                                                                        Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             (CH.sub.2).sub.2 CH.sub.3                                                                Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CF.sub.2 H                                                                               Cl     H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.2 CF.sub.3                                                                        Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                              Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              CH.sub.2 CH.sub. 2 OH                                                                    Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             OH        Cl     H  Cl   OCH.sub.3                                                                             CH                                             OSi(CH.sub.3).sub.3                                                                      Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCH.sub.3 Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              OCH.sub.2 CH.sub.3                                                                       Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             C.sub.6 H.sub.5                                                                          Cl     H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.2 C.sub.6 H.sub.5                                                                 Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CH.sub.3  H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              CH.sub.3  CH.sub.3                                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.3  OCH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CH.sub.3  F      H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.3  Br     H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              CH.sub.3  OSO.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.3  SO.sub.2 CH.sub.3                                                                     H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CH.sub.3  Cl     H  OCH.sub.3                                                                           N(CH.sub.3 ).sub.2                                                                    N                                              CH.sub.3  Cl     H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             CH.sub.3  Cl     H  OCH.sub.3                                                                           OCF.sub.2 H                                                                           CH                                             CH.sub.3  Cl     H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                           CH                                             H         Cl     H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             H         Cl     H  OCH.sub.3                                                                           CH.sub.2 S(O)CH.sub.3                                                                 CH                                             __________________________________________________________________________

                                      TABLE 8                                      __________________________________________________________________________     General Structure 8                                                            R.sub.1   R.sub.5     R  X    Y    Z  m.p. (°C.)                        __________________________________________________________________________     H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H  Cl   OCH.sub.3                                                                           CH                                          H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                           H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           H         SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  Cl   OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                           CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           CH.sub.2 CH.sub.3                                                                        SO.sub.2 N(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          (CH.sub.2).sub.2 CH.sub.3                                                                SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          CF.sub.2 H                                                                               SO.sub.2 N(CH.sub.3).sub.2                                                                 H  Cl   OCH.sub.3                                                                           CH                                          CH.sub.2 CF.sub.3                                                                        SO.sub.2 N(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                           CH.sub.2 CH.sub.2 OCH.sub.3                                                              SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           CH.sub.2 CH.sub.2 OH                                                                     SO.sub.2 N(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          OH        SO.sub.2 N(CH.sub.3).sub.2                                                                 H  Cl   OCH.sub.3                                                                           CH                                          OSi(CH.sub.3).sub.3                                                                      SO.sub.2 N(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                           OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           OCH.sub.2 CH.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          SO.sub.2 CH.sub.3                                                                        SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          C.sub.6 H.sub.5                                                                          SO.sub.2 N(CH.sub.3).sub.2                                                                 H  Cl   OCH.sub.3                                                                           CH                                          CH.sub.2 C.sub.6 H.sub.5                                                                 SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           CH.sub.3  CH.sub.3    H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                           CH.sub.3  CH.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          CH.sub.3  OCH.sub.3   H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          CH.sub.3  OCH.sub.2 CH.sub.3                                                                         H  Cl   OCH.sub.3                                                                           CH                                          CH.sub.3  F           H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                           CH.sub.3  Cl          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           CH.sub.3  Br          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                              H  Cl   OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                           CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                           CH.sub.3  SO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H  Cl   OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                           H         SO.sub.2 CH.sub.3                                                                          H  OCH.sub. 3                                                                          OCH.sub.3                                                                           N                                           H         OCH.sub.2 CH.sub.3                                                                         H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                          H         Cl          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                          H         Br          H  Cl   OCH.sub.3                                                                           CH                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                           H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           NH.sub.2                                                                            CH                                          __________________________________________________________________________

                                      TABLE 9                                      __________________________________________________________________________     General Structure 9                                                            L  R.sub.1   R.sub.6     R  X    Y    Z  m.p. (°C.)                     __________________________________________________________________________     L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               (CH.sub.2).sub.2 CH.sub.3                                                                CO.sub.2 CH.sub.3                                                                          H  OCH.sub. 3                                                                          OCH.sub.3                                                                           CH                                       L-4                                                                               CF.sub.2 H                                                                               CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.2 CF.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.2 CH.sub.2 OCH.sub.3                                                              CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.2 CH.sub.2 OH                                                                     CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               OH        CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               OSi(CH.sub.3).sub.3                                                                      CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               OCH.sub.3 CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               OCH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               SO.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               C.sub.6 H.sub.5                                                                          CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.2 C.sub.6 H.sub.5                                                                 CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  F           H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  Cl          H  OCH.sub. 3                                                                          OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  Br          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  SO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                        L-4                                                                               CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                         H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3) (CH.sub.2 ).sub.2 CH.sub.3                                            H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                 H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                       L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               (CH.sub.2).sub.2 CH.sub.3                                                                CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CF.sub.2 H                                                                               CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.2 CF.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.2 CH.sub.2 OCH.sub.3                                                              CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.2 CH.sub.2 OH                                                                     CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               OH        CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               OSi(CH.sub.3).sub.3                                                                      CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               OCH.sub.3 CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               OCH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               SO.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               C.sub.6 H.sub.5                                                                          CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.2 C.sub.6 H.sub.5                                                                 CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  F           H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  Cl          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  Br          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  SO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                        L-5                                                                               CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                         H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3) (CH.sub.2).sub.2 CH.sub.3                                             H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                 H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                       L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub. 3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               (CH.sub.2).sub.2 CH.sub.3                                                                CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CF.sub.2 H                                                                               CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.2 CF.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.2 CH.sub.2 OCH.sub.3                                                              CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.2 CH.sub.2 OH                                                                     CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               OH        CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               OSi(CH.sub.3).sub.3                                                                      CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               OCH.sub.3 CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               OCH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               SO.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               C.sub.6 H.sub.5                                                                          CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.2 C.sub.6 H.sub.5                                                                 CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  F           H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  Cl          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  Br          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  SO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                        L-6                                                                               CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                         H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3) (CH.sub.2).sub.2 CH.sub.3                                             H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                 H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                       __________________________________________________________________________

                                      TABLE 10                                     __________________________________________________________________________     General Structure 10                                                                                                           m.p.                           R.sub.9                                                                           R.sub.1   R.sub.7                                                                              R.sub.8                                                                           R.sub.3                                                                              Q.sub.1                                                                          m R  X    Y    Z  (°C.)                   __________________________________________________________________________     H  H         H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  H         H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  H         H     H  H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  H         H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  H         H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  H         H     H  H     O 0 CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.3                                                                        H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  (CH.sub.2).sub.2 CH.sub.3                                                                H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CF.sub.2 H                                                                               H     H  H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 CF.sub.3                                                                        H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.2 OH                                                                     H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  OH        H     H  H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  OSi(CH.sub.3).sub.3                                                                      H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  OCH.sub.3 H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  OCH.sub.2 CH.sub.3                                                                       H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  SO.sub.2 CH.sub.3                                                                        H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  C.sub.6 H.sub.5                                                                          H     H  H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 C.sub.6 H.sub.5                                                                 H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 CH.sub.3                                                                          H         H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 CH.sub.3                                                                          CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.3                                                                             H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.2 CH.sub.3                                                                    H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                            H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  (CH.sub.2) .sub.3 CH.sub.3                                                           H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-F   O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-Cl  O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-Br  O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-CF.sub.3                                                                           O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  6-CH.sub.3                                                                           O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  5-OCH.sub.3                                                                          O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OCF.sub.2 H                                                                        O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-OC.sub.2 H.sub.5                                                                   O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     O 0 H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                H  H         H     H  H     O 0 H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                 H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                H  H         H     H  H     O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                           OCH.sub. 3                                                                          CH                                H  CH.sub.2 CH.sub.3                                                                        H     H  H     O 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 CF.sub.3                                                                        H     H  H     O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CF.sub.2 H                                                                               H     H  H     O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          H     O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-F   O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-Cl  O 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-Br  O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  6-CF.sub.3                                                                           O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  5-CH.sub.3                                                                           O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OCH.sub.3                                                                          O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-OCF.sub.2 H                                                                        O 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                   O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  H         (CH.sub.2).sub. 3 CH.sub.3                                                           H  H     O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     O 1 CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     O 1 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                 H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   CH                                H  (CH.sub.2).sub.2 CF.sub.3                                                                H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  H         H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  H         H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  H         H     H  H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  H         H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  H         H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  H         H     H  H     S 0 CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.3                                                                        H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  (CH.sub.2).sub.2 CH.sub.3                                                                H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CF.sub.2 H                                                                               H     H  H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 CF.sub.3                                                                        H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.                                                                            N                                 H  CH.sub.2 CH.sub.2 OH                                                                     H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  OH        H     H  H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  OSi(CH.sub.3).sub.3                                                                      H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.                                                                            N                                 H  OCH.sub.3 H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  OCH.sub.2 CH.sub.3                                                                       H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  SO.sub.2 CH.sub.3                                                                        H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  C.sub.6 H.sub.5                                                                          H     H  H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 C.sub.6 H.sub.5                                                                 H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 CH.sub.3                                                                          H         H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 CH.sub.3                                                                          CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.3                                                                             H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.2 CH.sub.3                                                                    H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                            H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  (CH.sub.2) .sub.3 CH.sub.3                                                           H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-F   S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-Cl  S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-Br  S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-CF.sub.3                                                                           S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  6-CH.sub.3                                                                           S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  5-OCH.sub.3                                                                          S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OCF.sub.2 H                                                                        S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-OC.sub.2 H.sub.5                                                                   S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     S 0 H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                H  H         H     H  H     S 0 H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                 H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                H  H         H     H  H     S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.2 CH.sub.3                                                                        H     H  H     S 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 CF.sub.3                                                                        H     H  H     S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CF.sub.2 H                                                                               H     H  H     S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          H     S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-F   S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-Cl  S 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-Br  S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  6-CF.sub.3                                                                           S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  5-CH.sub.3                                                                           S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OCH.sub.3                                                                          S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-OCF.sub.2 H                                                                        S 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                   S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  H         (CH.sub.2).sub.3 CH.sub.3                                                            H  H     S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     S 1 CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     S 1 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                 H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   CH                                H  (CH.sub.2).sub.2 CF.sub.3                                                                H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  H         CH.sub.3                                                                             H  5-OCF.sub.3                                                                          O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                CH.sub.3                                                                          CH.sub.3  H     H  5-SCH.sub.3                                                                          O 0 H  OCH.sub.3                                                                           CH.sub.3                                                                            N                                 H  H         H     H  6-CH.sub.2 CH.sub.3                                                                  S 1 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                __________________________________________________________________________

                                      TABLE 11                                     __________________________________________________________________________     General Structure 11                                                                                                       m.p.                               R.sub.1   R.sub.10                                                                             R.sub.11                                                                          R.sub.3                                                                               Q.sub.2                                                                          R  X    Y    Z  (°C.)                       __________________________________________________________________________     H         H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                    H         H     H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                    H         H     H  H      O H  Cl   OCH.sub.3                                                                           CH                                    H         H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                     H         H     H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                     H         H     H  H      O CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           N                                     CH.sub.3  H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  H      O H  Cl   OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                     CH.sub.3  H     H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                     CH.sub.2 CH.sub.3                                                                        H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                    (CH.sub.2).sub.2 CH.sub. 3                                                               H     H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                    CF.sub.2 H                                                                               H     H  H      O H  Cl   OCH.sub.3                                                                           CH                                    CH.sub.2 CF.sub.3                                                                        H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                     CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                     CH.sub.2 CH.sub.2 OH                                                                     H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                    CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    H     H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                    OH        H     H  H      O H  Cl   OCH.sub.3                                                                           CH                                    OSi(CH.sub.3).sub.3                                                                      H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                     OCH.sub.3 H     H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                     OCH.sub.2 CH.sub.3                                                                       H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                    SO.sub.2 CH.sub.3                                                                        H     H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                    C.sub.6 H.sub.5                                                                          H     H  H      O H  Cl   OCH.sub.3                                                                           CH                                    CH.sub.2 C.sub.6 H.sub.5                                                                 H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                     CH.sub.3  CH.sub.3                                                                             H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                     CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                    CH.sub.3  CH.sub.2 CH.sub.3                                                                    H  H      O H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                    CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                            H  H      O H  Cl   OCH.sub.3                                                                           CH                                    CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                            H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                     CH.sub.3  H     H  5-F    O H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                     CH.sub.3  H     H  6-Cl   O H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  5-Br   O H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  6-CF.sub.3                                                                            O H  Cl   OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  5-CH.sub.3                                                                            O H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                     CH.sub.3  H     H  6-OCH.sub.3                                                                           O H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                     CH.sub.3  H     H  5-OCF.sub.2 H                                                                         O H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                    O H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                    H         H     H  H      S H  Cl   OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  H      S H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                     CH.sub.2 CH.sub.3                                                                        H     H  H      S H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                     CH.sub.2 CF.sub.3                                                                        H     H  H      S H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                    CF.sub.2 H                                                                               H     H  H      S H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                    CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          H      S H  Cl   OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  5-Cl   S H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                     CH.sub.3  H     H  5-CF.sub.3                                                                            S H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                     CH.sub.3  H     H  6-CH.sub.3                                                                            S H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  H      S H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                    CH.sub.3  H     H  H      O H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                     CH.sub.3  H     H  H      O H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                    CH.sub.3  H     H  H      O H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                    (CH.sub.2).sub.2 CF.sub.3                                                                H     H  H      O H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                     H         H     H  5-OCF.sub.3                                                                           O H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                    CH.sub.3  H     H  5-CH.sub.2 CH.sub.3                                                                   S H  Cl   OCH.sub.3                                                                           CH                                    CH.sub.3  H     H  6-CH.sub.2 SCH.sub.3                                                                  O H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                     __________________________________________________________________________

                                      TABLE 12                                     __________________________________________________________________________     General Structure 12                                                                                                           m.p.                           L  R.sub.1   R.sub.12 R.sub.3                                                                             R.sub.9                                                                           m R  X    Y    Z  (°C.)                   __________________________________________________________________________     L-9                                                                               H         CH.sub.3 H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                L-9                                                                               H         CH.sub.3 H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               H         CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                           CH                                L-9                                                                               H         CH.sub.3 H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 L-9                                                                               H         CH.sub.3 H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 L-9                                                                               H         CH.sub.3 H    H  0 CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.3  CH.sub.3 H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.3 H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.3 H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.3  CH.sub.3 H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.2 CH.sub.3                                                                        CH.sub.3 H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                L-9                                                                               (CH.sub.2).sub.2 CH.sub.3                                                                CH.sub.3 H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               CF.sub.2 H                                                                               CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.2 CF.sub.3                                                                        CH.sub.3 H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.2 CH.sub.2 CF.sub.3                                                               CH.sub.3 H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.2 CH.sub.2 OCH.sub.3                                                              CH.sub.3 H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3 H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                           CH                                L-9                                                                               OH        CH.sub.3 H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 L-9                                                                               OSi(CH.sub.3).sub.3                                                                      CH.sub.3 H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 L-9                                                                               OCH.sub.3 CH.sub.3 H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                L-9                                                                               OCH.sub.2 CH.sub.3                                                                       CH.sub.3 H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               SO.sub.2 CH.sub.3                                                                        CH.sub.3 H    H  0 H  Cl   OCH.sub.3                                                                           CH                                L-9                                                                               C.sub.6 H.sub.5                                                                          CH.sub.3 H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.2 C.sub.6 H.sub.5                                                                 CH.sub.3 H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 L-9                                                                               H         H        H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  H        H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.3                                                                       H    H  0 H  Cl   OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                               H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                               H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.3  (CH.sub.2).sub.4 CH.sub.3                                                               H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  (CH.sub.2).sub.5 CH.sub.3                                                               H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               H         CH.sub.3 H    CH.sub.3                                                                          0 H  Cl   OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.3 H    CH.sub.3                                                                          0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.3  CH.sub.3 6-F  H  0 H  OCH.sub.3                                                                           OCH.sub. 3                                                                          N                                 L-9                                                                               CH.sub.3  CH.sub.3 5-Cl H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.3 6-Br H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.3 5-CF.sub.3                                                                          H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.3 6-CH.sub.3                                                                          H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.3  CH.sub.3 5-OCH.sub.3                                                                         H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.3  CH.sub.3 6-OCF.sub.2 H                                                                       H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.3 5-OC.sub.2 H.sub.5                                                                  H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               H         CH.sub.3 H    H  1 H  Cl   OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.3 H    H  1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 L-9                                                                               CH.sub.3  CH.sub.3 H    H  1 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   CH                                L-9                                                                               CH.sub.3  CH.sub.3 H    H  0 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                L-9                                                                               CH.sub.3  CH.sub.3 H    H  0 H  OCH.sub.3                                                                           N(CH.sub.3) .sub.2                                                                  N                                 L-9                                                                               CH.sub.3  CH.sub.3 H    H  0 H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.2 Cl                                                                    H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.2 Cl                                                                    H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            N                                 L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.2 F                                                                     H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            N                                 L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.2 F                                                                     H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.2 CF.sub.3                                                                       H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  CH.sub.2 CF.sub.3                                                                       H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            N                                 L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.2 Br                                                                    H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            N                                 L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.2 OCH.sub.3                                                             H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            N                                 L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.2 OCH.sub.3                                                             H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            CH                                L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            CH                                L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            N                                 L-9                                                                               CH.sub.3  (CH.sub.2).sub.3 CH.sub.2 OCH.sub. 3                                                    H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            N                                 L-9                                                                               CH.sub.3  (CH.sub.2).sub.3 CH.sub.2 Cl                                                            H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            CH                                L-9                                                                               H         CO(CH.sub.2).sub.2 CH.sub.3                                                             H    H  0 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                L-9                                                                               CH.sub.3  CO.sub.2 C.sub.2 H.sub.5                                                                H    H  0 H  OCH.sub.3                                                                           CH.sub.3                                                                            N                                 L-9                                                                               CH.sub.3  CH.sub.2 CF.sub.3                                                                       H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                L-9                                                                               CH.sub.3  (CH.sub.2).sub.3 CH.sub.2 Br                                                            H    H  0 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                L-9                                                                               CH.sub.3  CH.sub.2 CH.sub.2 OCH.sub.3                                                             H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 __________________________________________________________________________

                                      TABLE 12A                                    __________________________________________________________________________     General Structure 12                                                                                                       m.p.                               L  R.sub.1   Q.sub.5                                                                            R.sub.3                                                                             R.sub.9                                                                           m R  X    Y     Z  (°C.)                       __________________________________________________________________________     L-10                                                                              H         O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   H    H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              H         O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              H         O   H    H  0 CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  NCH.sub.3                                                                          H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  NCH.sub.3                                                                          H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  NCH.sub.3                                                                          H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.2 CH.sub.3                                                                        NCH.sub.3                                                                          H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              (CH.sub.2).sub.2 CH.sub.3                                                                NH  H    H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              CF.sub.2 H                                                                               NH  H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.2 CF.sub.3                                                                        NH  H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.2 CH.sub.2 CF.sub.3                                                               NH  H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                              NH  H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.2 CH.sub.2 OH                                                                     O   H    H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              OH        O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              OSi(CH.sub.3).sub.3                                                                      O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              OCH.sub.3 O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              OCH.sub.2 CH.sub.3                                                                       O   H    H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              SO.sub.2 CH.sub.3                                                                        O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              C.sub.6 H.sub.5                                                                          O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                 O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   H    CH.sub.3                                                                          0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   H    CH.sub.3                                                                          0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   5-F  H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  O   6-Cl H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  O   5-Br H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   6-CF.sub.3                                                                          H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   5-CH.sub.3                                                                          H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   SCH.sub.3                                                                           H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  O   6-OCH.sub.3                                                                         H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  O   5-OCF.sub.2 H                                                                       H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  O   6-OCF.sub.2 H                                                                       H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   H    H  1 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   H    H  1 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.2 CH.sub.3                                                                        O   H    H  1 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.2 CF.sub.3                                                                        O   H    H  1 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CF.sub.2 H                                                                               O   H    H  1 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   H    H  1 H  OCH.sub.3                                                                           OCF.sub.2 H                                                                          CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                          CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                    N                                     L-10                                                                              CH.sub.3  O   H    H  0 H  CH.sub.3                                                                            CH.sub.3                                                                             CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.2 CF.sub.3                                                                   N                                     L-10                                                                              CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                   CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  CH.sub.3                                                                            CF.sub.3                                                                             CH                                    __________________________________________________________________________

                                      TABLE 12B                                    __________________________________________________________________________     General Structure 12                                                                                                   m.p.                                   L  R.sub.1                                                                             R.sub.26                                                                          R.sub.27                                                                          R.sub.3                                                                              R.sub.9                                                                           m R  X   Y    Z  (°C.)                           __________________________________________________________________________     L-11                                                                              CH.sub.3                                                                            H  Cl 6-F   H  1 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  Cl 6-Br  H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  Cl 5-OC.sub.2 H.sub.5                                                                   H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                         L-11                                                                              H    H  Cl OCF.sub.3                                                                            H  1 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                         L-11                                                                              H    H  Cl CH.sub.2 OCH.sub.3                                                                   H  0 H  Cl  OCH.sub.3                                                                           CH                                        L-11                                                                              H    H  H  H     H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                        L-11                                                                              H    H  H  H     H  0 CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  H  H     H  0 H  Cl  OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.2 CH.sub.3                                                                   H  H  H     H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                         L-11                                                                              CH.sub.2 CF.sub.3                                                                   H  H  H     H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                         L-11                                                                              CF.sub.2 H                                                                          H  H  H     H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                        L-11                                                                              OCH.sub.3                                                                           H  H  H     H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                        L-11                                                                              SO.sub.2 CH.sub.3                                                                   H  H  H     H  0 H  Cl  OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  H  H     CH.sub.3                                                                          0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                         L-11                                                                              CH.sub.3                                                                            H  H  5-Cl  H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                         L-11                                                                              CH.sub.3                                                                            H  H  6-CH.sub.3                                                                           H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  H  5-CF.sub.3                                                                           H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  H  6-OCF.sub.2 H                                                                        H  0 H  Cl  OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  H  5-OCH.sub.3                                                                          H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                         L-11                                                                              H    Cl Cl H     H  1 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                         L-11                                                                              CH.sub.3                                                                            Cl Cl H     H  1 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            Cl Cl H     H  1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                   N                                         L-11                                                                              CH.sub.3                                                                            Cl Cl H     H  0 H  OCH.sub.3                                                                          OCF.sub.2 H                                                                         CH                                        L-11                                                                              CH.sub.3                                                                            Cl Cl H     H  0 H  CH.sub.3                                                                           CF.sub.3                                                                            CH                                        __________________________________________________________________________

                                      TABLE 12C                                    __________________________________________________________________________     General Structure 12                                                                                                  m.p.                                    L  R.sub.1                                                                             R.sub.12  R.sub.3                                                                              R  X   Y    Z  (°C.)                            __________________________________________________________________________     L-12                                                                              H    CH.sub.3  OCH.sub.2 CF.sub.3                                                                   H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              H    CH.sub.2 CH.sub.3                                                                        CH.sub.2 OCH.sub.3                                                                   H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.3  CH.sub.2 SCH.sub.3                                                                   H  CH.sub.3                                                                           CH.sub.3                                                                            CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Br                                                   H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              H    CH.sub.2 OC.sub.2 H.sub.5                                                                H     H  CH.sub.3                                                                           CH.sub.3                                                                            CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CF.sub.3                                                                        H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H     H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              H    COC.sub.2 H.sub.5                                                                        H     H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                         L-12                                                                              H    CO.sub.2 C.sub.2 H.sub.5                                                                 H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              H    CH.sub.3  H     H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                         L-12                                                                              H    CH.sub.3  H     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  H     H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.2 CF.sub.3                                                                   CH.sub.3  H     H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.2 CH.sub.3                                                                   CH.sub.3  H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              CF.sub.2 H                                                                          CH.sub.3  H     H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                         L-12                                                                              OCH.sub.3                                                                           CH.sub.3  H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              SO.sub.2 CH.sub.3                                                                   CH.sub.3  H     H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            H         H     H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                        H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.3                                                                            (CH.sub.2).sub.5 CH.sub.3                                                                H     H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  5-F   H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  6-Cl  H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  5-Br  H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.3  6-CF.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.3  5-CH.sub.3                                                                           H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  6-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  5-OCF.sub.2 H                                                                        H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  6-OC.sub.2 H.sub.5                                                                   H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                          L-12                                                                              H    CH.sub.3  H     H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                   N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.3  H     H  CH.sub.3                                                                           CH.sub.3                                                                            CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  H     H  OCH.sub.3                                                                          OCF.sub.2 H                                                                         CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                     H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                     H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 F                                                                      H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 F                                                                      H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CF.sub.3                                                                        H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CF.sub.3                                                                        H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 Br                                                                     H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H  OCH.sub.3                                                                          CH.sub.3                                                                            CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                       H     H  OCH.sub.3                                                                          CH.sub.3                                                                            CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                       H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            (CH.sub.2).sub.3 CH.sub.2 OCH.sub.3                                                      H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            (CH.sub.2).sub.3 CH.sub.2 Cl                                                             H     H  OCH.sub.3                                                                          CH.sub.3                                                                            CH                                         __________________________________________________________________________

                                      TABLE 13                                     __________________________________________________________________________     General Structure 13                                                                                                         m.p.                             L  R.sub.1   R.sub.13                                                                             R.sub.3                                                                               R.sub.14                                                                          R  X   Y      Z  (°C.)                     __________________________________________________________________________     L-13                                                                              H         H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.2 CH.sub.3                                                                        H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              (CH.sub.2).sub.2 CH.sub.3                                                                H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-13                                                                              CF.sub.2 H                                                                               H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.2 CF.sub.3                                                                        H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.2 CH.sub.2 OH                                                                     H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-13                                                                              OH        H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              OSi(CH.sub.3).sub.3                                                                      H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              OCH.sub.3 H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              OCH.sub.2 CH.sub.3                                                                       H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              SO.sub.2 CH.sub.3                                                                        H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-13                                                                              C.sub.6 H.sub.5                                                                          H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                 H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     H      -- CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  CH.sub.3                                                                             H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  CH.sub.2 CH.sub.3                                                                    H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                            H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.3  H     5-F    -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     6-Cl   -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     5-Br   -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     6-CF.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.3  H     5-CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.3  H     6-OCH.sub.3                                                                           -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     5-OCF.sub.2 H                                                                         -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     6-OC.sub.2 H.sub.5                                                                    -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     H      -- H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-13                                                                              CH.sub.3  H     H      -- H  CH.sub.3                                                                           CF.sub.3                                                                              CH                                  L-13                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                     N                                   L-13                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          OCF.sub.2 H                                                                           CH                                  L-14                                                                              H         H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.2 CH.sub.3                                                                        H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              (CH.sub.2).sub.2 CH.sub.3                                                                H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-14                                                                              CF.sub.2 H                                                                               H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.2 CF.sub.3                                                                        H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.2 CH.sub.2 OH                                                                     H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-14                                                                              OH        H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-14                                                                              OSi(CH.sub.3).sub.3                                                                      H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              OCH.sub.3 H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              OCH.sub.2 CH.sub.3                                                                       H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              SO.sub.2 CH.sub.3                                                                        H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-14                                                                              C.sub.6 H.sub.5                                                                          H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                 H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     H      -- CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  CH.sub.3                                                                             H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  CH.sub.2 CH.sub.3                                                                    H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.3  (CH.sub. 2).sub.2 CH.sub.3                                                           H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.3  H     5-F    -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     6-Cl   -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     5-Br   -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     6-CF.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.3  H     5-CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.3  H     6-OCH.sub.3                                                                           -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     5-OCF.sub.2 H                                                                         -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     6-OC.sub.2 H.sub.5                                                                    -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     H      -- H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-14                                                                              CH.sub.3  H     H      -- H  CH.sub.3                                                                           CF.sub.3                                                                              CH                                  L-14                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                     N                                   L-14                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          OCF.sub.2 H                                                                           CH                                  L-15                                                                              H         CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  H  OCH.sub. 3                                                                         OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             H      H  H  Cl  OCH.sub.3                                                                             CH                                  L-15                                                                              (CH.sub.2).sub.2 CH.sub.3                                                                CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              CF.sub.2 H                                                                               CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                              CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                             H      H  H  Cl  OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              OH        CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              OSi(CH.sub.3).sub.3                                                                      CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              OCH.sub.3 CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              OCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             H      H  H  Cl  OCH.sub.3                                                                             CH                                  L-15                                                                              SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              C.sub.6 H.sub.5                                                                          CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                 CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              H         CH.sub.3                                                                             H      H  CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      CH.sub.3                                                                          H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.2 CH.sub.3                                                                    H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                            H      H  H  Cl  OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             6-F    H  H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             5-Cl   H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             6-Br   H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             5-CF.sub.3                                                                            H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             6-CH.sub.3                                                                            H  H  Cl  OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             5-OCH.sub.3                                                                           H  H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             6-OCF.sub.2 H                                                                         H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub. 3                                                                            5-OC.sub.2 H.sub.5                                                                    H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              H         CH.sub.3                                                                             6-Cl   H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                     N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                           CH                                  L-13                                                                              H         H     5-C.sub.2 H.sub.5                                                                     -- H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-13                                                                              CH.sub.3  CH.sub.3                                                                             6-OCH.sub.2 CF.sub.3                                                                  -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.3  CH.sub.3                                                                             6-SCH.sub.3                                                                           -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              H         H     5-CH.sub.2 OCH.sub.3                                                                  -- H  OCH.sub.3                                                                          C.tbd.CH                                                                              CH                                  L-13                                                                              H         H     5-CH.sub.2 SCH.sub.3                                                                  -- H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                 N                                   L-14                                                                              H         H     5-C.sub.2 H.sub.5                                                                     -- H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-14                                                                              CH        CH.sub.3                                                                             5-OCH.sub.2 CHF.sub.2                                                                 -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              H         H     6-CH.sub.2 SCH.sub.3                                                                  -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             5-SC.sub.2 H.sub.5                                                                    H  H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-15                                                                              H         CH.sub.3                                                                             6-OCH.sub.2 CH.sub.2 F                                                                H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              H         CH.sub.3                                                                             5-CH.sub.2 OCH.sub.3                                                                  H  H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                            N                                   __________________________________________________________________________

                                      TABLE 14                                     __________________________________________________________________________     General Structure 14                                                                                                           m.p.                           BP                                                                               R.sub.1   R.sub.16     R.sub.15                                                                             R  X    Y     Z  (°C.)                   __________________________________________________________________________     5 CH.sub.3  4-SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                5 CH.sub.3  4-SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                5 CH.sub.3  4-SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             H  Cl   OCH.sub.3                                                                            CH                                5 CH.sub.3  4-SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                 5 CH.sub.3  4-SO.sub.2 CH.sub.2 CH═CH.sub.2                                                         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                 5 CH.sub.3  4-OCF.sub.2 H                                                                               CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                4 H         3-Cl         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                4 CH.sub.3  3-CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             H  Cl   OCH.sub.3                                                                            CH                                4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                 4 CH.sub.3  3-CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                 4 CH.sub.3  3-CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                        CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             H  Cl   OCH.sub.3                                                                            CH                                4 CH.sub.3  3-CO.sub.2 CH.sub.2 CH═CH.sub.2                                                         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                 4 CH.sub.3  3-NO.sub.2   CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                 4 CH.sub.3  5-Br         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                4 CH.sub.3  5-CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                3 H         4-CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             H  Cl   OCH.sub.3                                                                            CH                                3 CH.sub.3  4-CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                 3 CH.sub.3  4-Cl         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                 3 CH.sub.3  4-SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                3 CH.sub.3  4-NO.sub.2   CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                3 CH.sub.3  4-F          CH.sub.3                                                                             H  OCF.sub.2 H                                                                         OCF.sub. 2 H                                                                         CH                                4 CH.sub.3  3-F          CH.sub.3                                                                             H  CH.sub.3                                                                            CF.sub.3                                                                             CH                                5 CH.sub.3  4-Cl         CH.sub.3                                                                             H  CH.sub.3                                                                            CH.sub.3                                                                             CH                                5 CH.sub.3  4-Br         CH.sub.3                                                                             H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                    N                                 5 CH.sub.3  4-Cl         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.2 CF.sub.3                                                                   N                                 5 CH        4-Cl         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCF.sub.2 H                                                                          CH                                5 H         4-Cl         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                5 CH.sub.3  4-Cl         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                5 CH.sub.2 CH.sub.3                                                                        4-Cl         CH.sub.3                                                                             H  Cl   OCH.sub.3                                                                            CH                                5 (CH.sub.2).sub.2 CH.sub.3                                                                4-Cl         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                 5 CF.sub.2 H                                                                               4-Cl         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                 5 CH.sub.2 CF.sub.3                                                                        4-Cl         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                5 CH.sub.2 CH.sub.2 OCH.sub.3                                                              4-Cl         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                5 CH.sub.2 CH.sub.2 OH                                                                     4-Cl         CH.sub.3                                                                             H  Cl   OCH.sub.3                                                                            CH                                5 CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    4-Cl         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                 5 OH        4-Cl         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                 5 OSi(CH.sub.3).sub.3                                                                      4-Cl         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                5 OCH.sub.3 4-Cl         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                5 OCH.sub.2 CH.sub.3                                                                       4-Cl         CH.sub.3                                                                             H  Cl   OCH.sub.3                                                                            CH                                5 SO.sub.2 CH.sub.3                                                                        4-Cl         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                 5 C.sub.6 H.sub.5                                                                          4-Cl         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                 5 CH.sub.2 C.sub.6 H.sub.5                                                                 4-Cl         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                5 H         4-Cl         CH.sub.3                                                                             CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                5 CH.sub.3  H            CH.sub.3                                                                             H  Cl   OCH.sub.3                                                                            CH                                5 CH.sub.3  4-Cl         H     H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                 5 CH.sub.3  4-Cl         CH.sub.2 CH.sub.3                                                                    H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                 5 CH.sub.3  4-Cl         (CH.sub.2).sub.2 CH.sub.3                                                            H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                5 CH.sub.3  4-CH.sub.3   CH.sub.3                                                                             H  Cl   OCH.sub.3                                                                            CH                                5 CH.sub.3  4-CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                5 CH.sub.3  4-(CH.sub.2).sub.2 CH.sub.3                                                                 CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                 5 CH.sub.3  4-F          CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                 5 CH.sub.3  4-Br         CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                5 CH.sub.3  4-NO.sub.2   CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                5 CH.sub.3  4-CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             H  Cl   OCH.sub.3                                                                            CH                                5 CH.sub.3  4-SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                 5 CH.sub.3  4-SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                             CH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                 __________________________________________________________________________      BP = Bridge Position                                                     

                  TABLE 15                                                         ______________________________________                                         General Structure 15                                                                                                     m.p.                                 R.sub.1     R.sub.15                                                                              R      X     Y       Z (°C.)                         ______________________________________                                         H           CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     CH.sub.3    CH.sub.3                                                                              H      OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      Cl    OCH.sub.3                                                                              CH                                     (CH.sub.2).sub.2 CH.sub.3                                                                  CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                              N                                      CF.sub.2 H  CH.sub.3                                                                              H      OCH.sub.3                                                                            OCH.sub.3                                                                              N                                      CH.sub.2 CF.sub.3                                                                          CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     CH.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                              H      OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     CH.sub.2 CH.sub.2 OH                                                                       CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                              N                                      CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                      CH.sub.3                                                                              H      OCH.sub.3                                                                            OCH.sub.3                                                                              N                                      OH          CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     OSi(CH.sub.3).sub.3                                                                        CH.sub.3                                                                              H      Cl    OCH.sub.3                                                                              CH                                     OCH.sub.3   CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                              N                                      OCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H      OCH.sub.3                                                                            OCH.sub.3                                                                              N                                      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     C.sub.6 H.sub.5                                                                            CH.sub.3                                                                              H      OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     CH.sub.2 C.sub.6 H.sub.5                                                                   CH.sub.3                                                                              H      CH.sub.3                                                                             OCH.sub.3                                                                              N                                      H           CH.sub.3                                                                              CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                              N                                      CH.sub.3                                                                               CH.sub.3   CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                              CH                                     CH.sub.3                                                                               CH.sub.2 CH.sub.3                                                                         H      OCH.sub.3                                                                            OCH.sub.3                                                                              CH                                     CH.sub.3                                                                               (CH.sub.2).sub.2 CH.sub.3                                                                 H      CH.sub.3                                                                             OCH.sub.3                                                                              N                                      H       CH.sub.3   H      CH.sub.3                                                                             CH.sub.3                                                                               CH                                     CH.sub.3                                                                               H          H      Cl    OCH.sub.3                                                                              CH                                     CH.sub.3                                                                               CH.sub.3   H      OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                      N                                      CH.sub.3                                                                               CH.sub.3   H      OCH.sub.3                                                                            OCH.sub.2 CF.sub.3                                                                     CH                                     CH.sub.3                                                                               CH.sub.3   H      OCH.sub.3                                                                            OCF.sub.2 H                                                                            CH                                     ______________________________________                                    

                                      TABLE 16                                     __________________________________________________________________________     General Structure 16                                                                                                    m.p.                                  R.sub.1                                                                              R.sub.2 R.sub.3                                                                              A   R   X.sub.1,2,3 or 4                                                                      Y.sub.1,2,3 or 4                                                                     (°C.)                          __________________________________________________________________________     H     SO.sub.2 CH.sub.3                                                                      H     A-2 H   CH.sub.3                                                                              O                                           CH.sub.3                                                                             CO.sub.2 CH.sub.3                                                                      H     A-2 H   CH.sub.3                                                                              O                                           CH.sub.2 CH.sub.3                                                                    SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-2 H   CH.sub.3                                                                              O                                           CH.sub.2 CF.sub.3                                                                    NO.sub.2                                                                               H     A-2 H   CH.sub.3                                                                              O                                           CF.sub.2 H                                                                           SO.sub.2 CH.sub.3                                                                      H     A-2 H   CH.sub.3                                                                              O                                           H     SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-2 H   OCH.sub.3                                                                             CH.sub.2                                    CH.sub.3                                                                             OSO.sub.2 CH.sub.3                                                                     H     A-2 H   OCH.sub.3                                                                             CH.sub.2                                    H     CO.sub.2 CH.sub.2 CH.sub.3                                                             H     A-2 H   H      O                                           CH.sub.3                                                                             NO.sub.2                                                                               H     A-2 H   H      O                                           H     SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-2 H   OCH.sub.3                                                                             O                                           CH.sub.3                                                                             OSO.sub.2 CH.sub.3                                                                     H     A-2 H   OCH.sub.3                                                                             O                                           CH.sub.3                                                                             SO.sub.2 CH.sub.3                                                                      5-OCH.sub.3                                                                          A-2 H   OCH.sub.3                                                                             O                                           H     NO.sub.2                                                                               H     A-2 CH.sub.3                                                                           CH.sub.3                                                                              O                                           H     SO.sub.2 CH.sub.3                                                                      H     A-3 H   CH.sub.3                                                                              --                                          CH.sub.3                                                                             SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-3 H   CH.sub.3                                                                              --                                          CH.sub.2 CH.sub.3                                                                    CO.sub.2 CH.sub.3                                                                      H     A-3 H   CH.sub.3                                                                              --                                          CH.sub.2 CF.sub.3                                                                    SO.sub.2 CH.sub.3                                                                      H     A-3 H   CH.sub.3                                                                              --                                          CF.sub.2 H                                                                           OSO.sub.2 CH.sub.3                                                                     H     A-3 H   CH.sub.3                                                                              --                                          H     SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-3 H   H      --                                          CH.sub.3                                                                             CO.sub.2 CH.sub.3                                                                      H     A-3 H   H      --                                          H     SO.sub.2 CH.sub.3                                                                      H     A-3 H   OCH.sub.3                                                                             --                                          CH.sub.3                                                                             SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-3 H   OCH.sub.3                                                                             --                                          CH.sub.2 CF.sub.3                                                                    OSO.sub.2 CH.sub.3                                                                     H     A-3 H   OCH.sub.3                                                                             --                                          CF.sub.2 H                                                                           CO.sub.2 CH.sub.3                                                                      H     A-3 H   OCH.sub.3                                                                             --                                          SO.sub.2 CH.sub.3                                                                    SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-3 H   OCH.sub.3                                                                             --                                          H     OSO.sub.2 CH.sub.3                                                                     H     A-4 H   CH.sub.3                                                                              CH.sub.3                                    CH.sub.3                                                                             SO.sub.2 CH.sub.3                                                                      H     A-4 H   CH.sub.3                                                                              CH.sub.3                                    CH.sub.2 CH.sub.3                                                                    CO.sub.2 CH.sub.3                                                                      H     A-4 H   CH.sub.3                                                                              CH.sub.3                                    CH.sub.2 CF.sub.3                                                                    NO.sub.2                                                                               H     A-4 H   CH.sub.3                                                                              CH.sub.3                                    CF.sub.2 H                                                                           SO.sub.2 CH.sub.3                                                                      H     A-4 H   CH.sub.3                                                                              CH.sub.3                                    H     SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-4 H   OCH.sub.3                                                                             CH.sub.3                                    CH.sub.3                                                                             SO.sub.2 CH.sub.3                                                                      H     A-4 H   OCH.sub.3                                                                             CH.sub.3                                    H     NO.sub.2                                                                               H     A-4 H   H      CH.sub.3                                    CH.sub.3                                                                             CO.sub.2 CH.sub.3                                                                      H     A-4 H   H      CH.sub.3                                    H     SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-4 H   CH.sub.3                                                                              H                                           CH.sub.3                                                                             CO.sub.2 CH.sub.3                                                                      H     A-4 H   CH.sub.3                                                                              H                                           H     SO.sub.2 CH.sub.3                                                                      H     A-4 H   OCH.sub.3                                                                             H                                           CH.sub.3                                                                             OSO.sub.2 CH.sub.3                                                                     H     A-4 H   OCH.sub.3                                                                             H                                           H     CO.sub.2 CH.sub.3                                                                      H     A-4 H   H      H                                           CH.sub.3                                                                             SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-4 H   H      H                                           H     SO.sub.2 CH.sub.3                                                                      H     A-5 H   CH.sub.3                                                                              OCH.sub.3                                   CH.sub.3                                                                             CO.sub.2 CH.sub.3                                                                      H     A-5 H   C.sub.2 H.sub.5                                                                       SCH.sub.3                                   C.sub.2 H.sub.5                                                                      SO.sub.2 N(CH.sub.3 ).sub.2                                                            H     A-5 H   CH.sub.2 CF.sub.3                                                                     OCF.sub.2 H                                 H     SO.sub.2 CH.sub.3                                                                      H     A-6 H   CH.sub.3                                                                              --                                          CH.sub.3                                                                             NO.sub.2                                                                               H     A-6 H   OCH.sub.3                                                                             --                                          CF.sub.2 H                                                                           CO.sub.2 CH.sub.3                                                                      H     A-6 H   CH.sub.3                                                                              --                                          H     SO.sub.2 N(CH.sub.3).sub.2                                                             H     A-7 H   OCH.sub.3                                                                             OCH.sub.3                                   CH.sub.3                                                                             NO.sub.2                                                                               H     A-7 H   Cl     OCH.sub.3                                   C.sub.2 H.sub.5                                                                      Cl      H     A-7 H   CH.sub.2 OCH.sub.3                                                                    CH.sub.3                                    CH.sub.2 CF.sub.3                                                                    CO.sub.2 CH.sub.3                                                                      H     A-7 H   CH.sub.3                                                                              Cl                                          __________________________________________________________________________

                                      TABLE 17                                     __________________________________________________________________________     General Structure 17                                                           R.sub.2   R.sub.3                                                                               R  X    Y      Z  m.p. (°C.)                           __________________________________________________________________________     CH.sub.3  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              (CH.sub.2).sub.2 CH.sub.3                                                                H      H  Cl   OCH.sub.3                                                                             CH                                             OCH.sub.3 H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              O(CH.sub.2).sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  Cl   OCH.sub.3                                                                             CH                                             Cl        6-Cl   H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             NO.sub.2  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CF.sub.3  H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        3-CH.sub.3                                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub. 3                                                                       5-OCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                               5-F    H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH(CH.sub.3).sub.2                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Br        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 N(OCH.sub.3)CH.sub.3                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              OSO.sub.2 CH.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             OSO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                       H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCHF.sub.2                                                                               H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-1,3,4-                                                                          H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             oxadiazol-2-yl                                                                 5-methyl-1,3,4-                                                                          H      H  OCH.sub.3                                                                           OCH.sub. 3                                                                            N                                              oxadiazol-2-yl                                                                 1,2,3-thiadiazol-                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              4-yl                                                                           1,2,3-thiadiazol-                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             4-yl                                                                           CO.sub.2 CH.sub.2 CH═CH.sub.2                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SCH.sub.3 H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             OCHFCHF.sub.2                                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SCF.sub.3 5-Cl   H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             SCH.sub.2 CCl.sub.3                                                                      H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              SO.sub.2 CH.sub.2 CH.sub.2 Br                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             COCH.sub.2 CH.sub.3                                                                      5-SCH.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             S(O)CH.sub.3                                                                             H      H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.2 OCF.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             2-methyl-isoxa-                                                                          H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              zol-4-yl                                                                       2-methyl-iso-                                                                            H      H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             thiazol-4-yl                                                                   isothiazol-5-yl                                                                          H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-iso-                                                                            H      H  Cl   OCH.sub.3                                                                             CH                                             thiazol-2-yl                                                                   CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 CH.sub.3                                                                   H  OCH.sub.3                                                                           CH.sub.3                                                                              CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 OCH.sub.3                                                                  H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        6-SCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           CH.sub.2 S(O)CH.sub.3                                                                 CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-OCF.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        5-CH.sub.2 SCH.sub.3                                                                  H  Cl   OCH.sub.3                                                                             CH                                             Cl        5-OCH.sub.2 CHF.sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  OCF.sub.2 H                                                                         NH.sub.2                                                                              CH                                             Cl        H      H  OCH.sub.3                                                                           CH.sub.2 SO.sub.2 CH.sub.3                                                            N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CH                                                                              N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CCH.sub.3                                                                       N                                              __________________________________________________________________________

                                      TABLE 18                                     __________________________________________________________________________     General Structure 18                                                           R.sub.2   R.sub.3                                                                               R  X    Y      Z  m.p. (°C.)                           __________________________________________________________________________     CH.sub.3  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              (CH.sub.2).sub.2 CH.sub.3                                                                H      H  Cl   OCH.sub.3                                                                             CH                                             OCH.sub.3 H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              O(CH.sub.2).sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  Cl   OCH.sub.3                                                                             CH                                             Cl        6-Cl   H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             NO.sub.2  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CF.sub.3  H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        3-CH.sub.3                                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        5-OCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                               5-F    H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH(CH.sub.3).sub.2                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Br        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 N(OCH.sub.3)CH.sub.3                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              OSO.sub.2 CH.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             OSO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                       H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCHF.sub.2                                                                               H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-1,3,4-                                                                          H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             oxadiazol-2-yl                                                                 5-methyl-1,3,4-                                                                          H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              oxadiazol-2-yl                                                                 1,2,3-thiadiazol-                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              4-yl                                                                           1,2,3-thiadiazol-                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             4-yl                                                                           CO.sub.2 CH.sub.2 CH═CH.sub.2                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SCH.sub.3 H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             OCHFCHF.sub.2                                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SCF.sub.3 5-Cl   H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             SCH.sub.2 CCl.sub.3                                                                      H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              SO.sub.2 CH.sub.2 CH.sub.2 Br                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             COCH.sub.2 CH.sub.3                                                                      5-SCH.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             S(O)CH.sub.3                                                                             H      H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.2 OCF.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             2-methyl-isoxa-                                                                          H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              zol-4-yl                                                                       2-methyl-iso-                                                                            H      H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             thiazol-4-yl                                                                   isothiazol-5-yl                                                                          H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-iso-                                                                            H      H  Cl   OCH.sub.3                                                                             CH                                             thiazol-2-yl                                                                   CO.sub.2 CH.sub.3                                                                        5-CH.sub. 2 CH.sub.3                                                                  H  OCH.sub.3                                                                           CH.sub.3                                                                              CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 OCH.sub.3                                                                  H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        6-SCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           CH.sub.2 S(O)CH.sub.3                                                                 CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-OCF.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        5-CH.sub.2 SCH.sub.3                                                                  H  Cl   OCH.sub.3                                                                             CH                                             Cl        5-OCH.sub.2 CHF.sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  OCF.sub.2 H                                                                         NH.sub.2                                                                              CH                                             Cl        H      H  OCH.sub.3                                                                           CH.sub.2 SO.sub.2 CH.sub.3                                                            N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CH                                                                              N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CCH.sub.3                                                                       N                                              __________________________________________________________________________

                                      TABLE 19                                     __________________________________________________________________________     General Structure 19                                                           R.sub.2   R.sub.3                                                                               R  X    Y      Z  m.p. (°C.)                           __________________________________________________________________________     CH.sub.3  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              (CH.sub.2).sub.2 CH.sub.3                                                                H      H  Cl   OCH.sub.3                                                                             CH                                             OCH.sub.3 H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              O(CH.sub.2).sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  Cl   OCH.sub.3                                                                             CH                                             Cl        6-Cl   H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             NO.sub.2  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CF.sub.3  H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        3-CH.sub.3                                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        5-OCH.sub.3                                                                           H  OCH.sub. 3                                                                          OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                               5-F    H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH(CH.sub.3).sub.2                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Br        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 N(OCH.sub.3)CH.sub.3                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              OSO.sub.2 CH.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             OSO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                       H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCHF.sub.2                                                                               H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-1,3,4-                                                                          H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             oxadiazol-2-yl                                                                 5-methyl-1,3,4-                                                                          H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              oxadiazol-2-yl                                                                 1,2,3-thiadiazol-                                                                        H      H  CH.sub. 3                                                                           OCH.sub.3                                                                             N                                              4-yl                                                                           1,2,3-thiadiazol-                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             4-yl      3                                                                    CO.sub.2 CH.sub.2 CH═CH.sub.2                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SCH.sub.3 H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             OCHFCHF.sub.2                                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SCF.sub.3 5-Cl   H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             SCH.sub.2 CCl.sub.3                                                                      H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              SO.sub.2 CH.sub.2 CH.sub.2 Br                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             COCH.sub.2 CH.sub.3                                                                      5-SCH.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             S(O)CH.sub.3                                                                             H      H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.2 OCF.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             2-methyl-isoxa-                                                                          H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              zol-4-yl                                                                       2-methyl-iso-                                                                            H      H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             thiazol-4-yl                                                                   isothiazol-5-yl                                                                          H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-iso-                                                                            H      H  Cl   OCH.sub.3                                                                             CH                                             thiazol-2-yl                                                                   CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 CH.sub.3                                                                   H  OCH.sub.3                                                                           CH.sub.3                                                                              CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 OCH.sub.3                                                                  H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        6-SCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           CH.sub.2 S(O)CH.sub.3                                                                 CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-OCF.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        5-CH.sub.2 SCH.sub.3                                                                  H  Cl   OCH.sub.3                                                                             CH                                             Cl        5-OCH.sub.2 CHF.sub.3                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  OCF.sub.2 H                                                                         NH.sub.2                                                                              CH                                             Cl        H      H  OCH.sub.3                                                                           CH.sub.2 SO.sub.2 CH.sub.3                                                            N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CH                                                                              N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CCH.sub.3                                                                       N                                              __________________________________________________________________________

                                      TABLE 20                                     __________________________________________________________________________     General Structure 20                                                           R         R.sub.3                                                                               R  X    Y      Z  m.p. (°C.)                           __________________________________________________________________________     CH.sub.3  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              (CH.sub.2).sub.2 CH.sub.3                                                                H      H  Cl   OCH.sub.3                                                                             CH                                             OCH.sub.3 H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              O(CH.sub.2).sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  Cl   OCH.sub.3                                                                             CH                                             Cl        6-Cl   H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             NO.sub.2  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CF.sub.3  H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        3-CH.sub.3                                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-Cl   H  CH.sub.3                                                                            OCH.sub. 3                                                                            N                                              CO.sub.2 CH.sub.3                                                                        5-OCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                               5-F    H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH(CH.sub.3).sub.2                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Br        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 N(OCH.sub.3)CH.sub.3                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              OSO.sub.2 CH.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             OSO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                       H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCHF.sub.2                                                                               H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-1,3,4-                                                                          H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             oxadiazol-2-yl                                                                 5-methyl-1,3,4-                                                                          H      H  OCH.sub.3                                                                           OCH.sub. 3                                                                            N                                              oxadiazol-2-yl                                                                 1,2,3-thiadiazol-                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              4-yl                                                                           1,2,3-thiadiazol-                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             4-yl                                                                           CO.sub.2 CH.sub.2 CH═CH.sub.2                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SCH.sub.3 H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             OCHFCHF.sub.2                                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SCF.sub.3 5-Cl   H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             SCH.sub.2 CCl.sub.3                                                                      H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              SO.sub.2 CH.sub.2 CH.sub.2 Br                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             COCH.sub.2 CH.sub.3                                                                      5-SCH.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             S(O)CH.sub.3                                                                             H      H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.2 OCF.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             2-methyl-isoxa-                                                                          H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              zol-4-yl                                                                       2-methyl-iso-                                                                            H      H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             thiazol-4-yl                                                                   isothiazol-5-yl                                                                          H      CH.sub.3                                                                          OCH.sub. 3                                                                          OCH.sub.3                                                                             N                                              5-methyl-iso-                                                                            H      H  Cl   OCH.sub.3                                                                             CH                                             thiazol-2-yl                                                                   CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 CH.sub.3                                                                   H  OCH.sub.3                                                                           CH.sub.3                                                                              CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 OCH.sub.3                                                                  H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        6-SCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           CH.sub.2 S(O)CH.sub.3                                                                 CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-OCF.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        5-CH.sub.2 SCH.sub.3                                                                  H  Cl   OCH.sub.3                                                                             CH                                             Cl        5-OCH.sub.2 CHF.sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  OCF.sub.2 H                                                                         NH.sub.2                                                                              CH                                             Cl        H      H  OCH.sub.3                                                                           CH.sub.2 SO.sub.2 CH.sub.3                                                            N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CH                                                                              N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CCH.sub.3                                                                       N                                              __________________________________________________________________________

                                      TABLE 21                                     __________________________________________________________________________     General Structure 21                                                           R.sub.2   R.sub.3                                                                               R  X    Y      Z  m.p. (°C.)                           __________________________________________________________________________     CH.sub.3  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CH.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              (CH.sub.2).sub.2 CH.sub.3                                                                H      H  Cl   OCH.sub.3                                                                             CH                                             OCH.sub.3 H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCH.sub.2 CH.sub.3                                                                       H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              O(CH.sub.2).sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  Cl   OCH.sub.3                                                                             CH                                             Cl        6-Cl   H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             NO.sub.2  H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CF.sub.3  H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        H      CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        3-CH.sub.3                                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.3                                                                            H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.3                                                                        5-OCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              CO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.2 CH.sub.3                                                               5-F    H  Cl   OCH.sub.3                                                                             CH                                             CO.sub.2 CH(CH.sub.3).sub.2                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Br        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SO.sub.2 N(CH.sub.3).sub.2                                                               H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-Cl   H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 N(OCH.sub.3)CH.sub.3                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              OSO.sub.2 CH.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             OSO.sub.2 CH.sub.2 CH.sub.3                                                              H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                       H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.2 CH.sub.3                                                               H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              OCHF.sub.2                                                                               H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-1,3,4-                                                                          H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             oxadiazol-2-yl                                                                 5-methyl-1,3,4-                                                                          H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              oxadiazol-2-yl                                                                 1,2,3-thiadiazol-                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              4-yl                                                                           1,2,3-thiadiazol-                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             4-yl                                                                           CO.sub.2 CH.sub.2 CH═CH.sub.2                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             Cl        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              Cl        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             CH                                             SO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SO.sub.2 CH.sub.3                                                                        H      H  CH.sub.3                                                                            OCH.sub.3                                                                             N                                              SCH.sub.3 H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             OCHFCHF.sub.2                                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              SCF.sub.3 5-Cl   H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             SCH.sub.2 CCl.sub.3                                                                      H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              SO.sub.2 CH.sub.2 CH.sub.2 Br                                                            H      H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             COCH.sub.2 CH.sub.3                                                                      5-SCH.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             S(O)CH.sub.3                                                                             H      H  Cl   OCH.sub.3                                                                             CH                                             CH.sub.2 OCF.sub.3                                                                       H      H  Cl   OCH.sub.3                                                                             CH                                             2-methyl-isoxa-                                                                          H      H  OCH.sub.3                                                                           CH.sub.3                                                                              N                                              zol-4-yl                                                                       2-methyl-iso-                                                                            H      H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             thiazol-4-yl                                                                   isothiazol-5-yl                                                                          H      CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              5-methyl-iso-                                                                            H      H  Cl   OCH.sub.3                                                                             CH                                             thiazol-2-yl                                                                   CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 CH.sub.3                                                                   H  OCH.sub.3                                                                           CH.sub.3                                                                              CH                                             CO.sub.2 CH.sub.3                                                                        5-CH.sub.2 OCH.sub.3                                                                  H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        6-SCH.sub.3                                                                           H  OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                             CO.sub.2 CH.sub.3                                                                        H      H  OCH.sub.3                                                                           CH.sub.2 S(O)CH.sub.3                                                                 CH                                             SO.sub.2 N(CH.sub.3).sub.2                                                               5-OCF.sub.3                                                                           H  CH.sub.3                                                                            CH.sub.3                                                                              CH                                             Cl        5-CH.sub.2 SCH.sub.3                                                                  H  Cl   OCH.sub.3                                                                             CH                                             Cl        5-OCH.sub.2 CHF.sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                             N                                              Cl        H      H  OCF.sub.2 H                                                                         NH.sub.2                                                                              CH                                             Cl        H      H  OCH.sub.3                                                                           CH.sub.2 SO.sub.2 CH.sub.3                                                            N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CH                                                                              N                                              Cl        H      H  OCH.sub.3                                                                           C.tbd.CCH.sub.3                                                                       N                                              __________________________________________________________________________

                                      TABLE 22                                     __________________________________________________________________________     General Structure 22                                                           R.sub.1   R.sub.2      R.sub.3                                                                             R  X       Y             Z  m.p.                   __________________________________________________________________________                                                             (°C.)           (CH.sub.2).sub.2 CH.sub.3                                                                SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               OCH.sub.3     CH                        CH.sub.2 CH.sub.2 F                                                                      CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.2 CH.sub.2 F                                                                      SO.sub.2 CH.sub.3                                                                           H    H  Cl      OCH.sub.3     CH                        CH.sub.2 CH.sub.2 CH.sub.2 F                                                             SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.2 CH.sub.2 CH.sub.2 F                                                             CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.2 CH.sub.2 CF.sub.3                                                               SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               OCH.sub.3     CH                        CH.sub.2 CHFCH.sub.2 F                                                                   SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.2 CH.sub.2 OCH.sub.3                                                              CO.sub.2 CH.sub.3                                                                           H    H  Cl      OCH.sub.3     CH                        CH.sub.2 CH.sub.2 OH                                                                     SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                              OCH.sub.3     N                         OH        SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               OCH.sub.3     CH                        Osi(CH.sub.3).sub.3                                                                      CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        OCH.sub.3 SO.sub.2 CH.sub.3                                                                           H    H  Cl      OCH.sub.3     CH                        OCH.sub.2 CH.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               OCH.sub.3     N                         SO.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              OCH.sub.3     N                         C.sub.6 H.sub.5                                                                          SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               OCH.sub.3     CH                        CH.sub.2 C.sub.6 H.sub.5                                                                 SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        OCH.sub.3 CO.sub.2 CH.sub.3                                                                           H    CH.sub.3                                                                          CH.sub.3                                                                               OCH.sub.3     CH                        SO.sub.2 CH.sub.3                                                                        SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.2 C.sub.6 H.sub.5                                                                 CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              OCH.sub.3     N                         OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               CH.sub.3      CH                        SO.sub. 2 CH.sub.3                                                                       SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              N(CH.sub.3).sub.2                                                                            N                         CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                                   H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         (CH.sub.2).sub.3 CH.sub.3                                                                   H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  O(CH.sub.2).sub.3 CH.sub.3                                                                  H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         O(CH.sub.2).sub.3 CH.sub.3                                                                  H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  OCH.sub.2 CH.sub.2 OCH.sub.3                                                                H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         OCH.sub.2 CH.sub.2 OCH.sub.3                                                                H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  F            H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         F            H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                          H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                          H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                        H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                        H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                               H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                               H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  OCF.sub.3    H    H  OCH.sub.3                                                                              OCH.sub.3     N                         H         OCF.sub.3    H    H  CH.sub.3                                                                               OCH.sub.3     CH                        CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                         H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        H         SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                         H    H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                               H    H  OCH.sub.3                                                                              OCH.sub.3     N                         H         SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                               H    H  CH.sub.3                                                                               OCH.sub.3     CH                        CH.sub.3  OSO.sub.2 N(CH.sub.3).sub.2                                                                 H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         OSO.sub.2 N(CH.sub.3).sub.2                                                                 H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  OSO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         OSO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                           H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         SO.sub.2 CH.sub.2 CH═CH.sub.2                                                           H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  SCF.sub.3    H    H  OCH.sub.3                                                                              OCH.sub.3     N                         H         SCF.sub.3    H    H  CH.sub.3                                                                               OCH.sub.3     CH                        CH.sub.3  SO.sub.2 CF.sub.3                                                                           H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         SO.sub.2 CF.sub.3                                                                           H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  SCF.sub.2 H  H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         SCF.sub.2 H  H    H  Cl      OCH.sub.3     CH                        CH.sub.3  SO.sub.2 CF.sub.2 H                                                                         H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        H         SO.sub.2 CF.sub.2 H                                                                         H    H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.3  OCH.sub.2 CH═CH.sub.2                                                                   H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         OCH.sub.2 CH═CH.sub.2                                                                   H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  OCH.sub.2 CH═CHCH.sub.3                                                                 H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         OCH.sub.2 CH═CHCH.sub.3                                                                 H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  OCH.sub.2 C.tbd.CH                                                                          H    H  OCH.sub.3                                                                              OCH.sub.3     N                         H         OCH.sub.2 C.tbd.CH                                                                          H    H  CH.sub.3                                                                               OCH.sub.3     CH                        CH.sub.3  OCH.sub.2 C.tbd.CCH.sub.3                                                                   H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        H         OCH.sub.2 C.tbd.CCH.sub.3                                                                   H    H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.3  CH.sub.2 OCH.sub.3                                                                          H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         CH.sub.2 OCH.sub.3                                                                          H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  CH.sub.2 OCH.sub.2 CH.sub.3                                                                 H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         CH.sub.2 OCH.sub.2 CH.sub.3                                                                 H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  (CH.sub.2).sub.2 OCH.sub.3                                                                  H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         (CH.sub.2).sub.2 OCH.sub.3                                                                  H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                         H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         (CH.sub.2).sub.2 OCH.sub.2 CH.sub.3                                                         H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  C.sub.6 H.sub.5                                                                             H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         C.sub.6 H.sub.5                                                                             H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  1,3,4,oxadiazol-2-yl                                                                        H    H  OCH.sub.3                                                                              OCH.sub.3     N                         H         1,3,4-oxadiazol-2-yl                                                                        H    H  CH.sub.3                                                                               OCH.sub.3     CH                        CH.sub.3  5-isoxazolyl H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        H         5-isoxazolyl H    H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.3  3-isoxazolyl H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         3-isoxazolyl H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  4-isoxazolyl H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         4-isoxazolyl H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  1-methyl-1H--pyrazol-3-yl                                                                   H    H  OCH.sub.3                                                                              OCH.sub.3     N                         H         1-methyl-1H--pyrazol-3-yl                                                                   H    H  CH.sub.3                                                                               OCH.sub.3     CH                        CH.sub.3  1H--pyrazol-1-yl                                                                            H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        H         1H--Pyrazol-1-yl                                                                            H    H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.3  1H--1,2,4-triazol-1-yl                                                                      H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         1H--1,2,4-triazol-1-yl                                                                      H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  tetrahydro-2-furanyl                                                                        H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         tetrahydro-2-furanyl                                                                        H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  2-furanyl    H    H  CH.sub.3                                                                               OCH.sub.3     N                         H         2-furanyl    H    H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  2-thienyl    H    H  CH.sub.3                                                                               OCH.sub.3     CH                        H         2-thienyl    H    H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  5-F  H  CH.sub.3                                                                               OCH.sub.3     N                         H         CO.sub.2 CH.sub.3                                                                           3-F  H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           3-Cl H  OCH.sub.3                                                                              OCH.sub.3     CH                        H         OCF.sub.2 H  6-Cl H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.3  SO.sub.2 CH.sub.3                                                                           6-Br H  CH.sub.3                                                                               OCH.sub.3     N                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                  5-Br H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                  5-CF.sub.3                                                                          H  OCH.sub.3                                                                              OCH.sub.3     CH                        H         Cl           6-CF.sub.3                                                                          H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.3  OSO.sub.2 CH.sub.3                                                                          6-CH.sub.3                                                                          H  OCH.sub.3                                                                              OCH.sub.3     N                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                  5-CH.sub.3                                                                          H  CH.sub.3                                                                               OCH.sub.3     CH                        CH.sub.3  SO.sub.2 CH.sub.3                                                                           3-OCH.sub.3                                                                         H  OCH.sub.3                                                                              OCH.sub.3     CH                        H         CO.sub.2 CH.sub.3                                                                           5-OCH.sub.3                                                                         H  CH.sub.3                                                                               OCH.sub.3     N                         CH.sub.3  SO.sub.2 CH.sub.3                                                                           6-OCF.sub.2 H                                                                       H  CH.sub.3                                                                               OCH.sub.3     N                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                  5-OCF.sub.2 H                                                                       H  OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           5-OC.sub.2 H.sub.5                                                                  H  CH.sub.3                                                                               OCH.sub.3     CH                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                  6-OC.sub.2 H.sub.5                                                                  H  OCH.sub.3                                                                              OCH.sub.3     N                         CH.sub.3  OCH.sub.2 CH.sub.3                                                                          6-Cl CH.sub.3                                                                          CH.sub.3                                                                               OCH.sub.3     N                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                  5-OCH.sub.3                                                                         CH.sub.3                                                                          OCH.sub.3                                                                              OCH.sub.3     CH                        CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  CH.sub.3                                                                               CH.sub.3      CH                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                              OC.sub.2 H.sub.5                                                                             N                         CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  OC.sub.2 H.sub.5                                                                       CH.sub.3      N                         H         OSO.sub.2 CH.sub.3                                                                          H    H  OC.sub.2 H.sub.5                                                                       OC.sub.2 H.sub.5                                                                             CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  Cl      OCH.sub.3     CH                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  Cl      OC.sub.2 H.sub.5                                                                             CH                        CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  F       OCH.sub.3     CH                        H         SO.sub.2 N(OCH.sub.3)CH.sub.3                                                               H    H  F       OCH.sub.3     CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  Br      OCH.sub.3     CH                        H         OSO.sub.2 CH.sub.3                                                                          H    H  Br      OCH.sub.3     CH                        CH.sub.3  NO.sub.2     H    H  I       OCH.sub.3     CH                        H         CO.sub.2 CH.sub.3                                                                           H    H  I       OCH.sub.3     CH                        CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  OCF.sub.2 H                                                                            CH.sub.3      CH                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCF.sub.2 H                                                                            OCF.sub.2 H   CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.2 F                                                                             CH.sub.3      N                         H         Cl           6-Cl H  CH.sub.2 F                                                                             OCH.sub.3     CH                        CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.2 CH.sub.2 F                                                                   OCH.sub.3     CH                        H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.2 CH.sub.2 F                                                                   CH.sub.3      N                         CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  OCH.sub.2 CHF.sub.2                                                                    CH.sub.3      N                         H         NO.sub.2     H    H  OCH.sub.2 CHF.sub.2                                                                    OCH.sub.3     CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.2 CF3                                                                          OCH.sub.3     CH                        H         OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub. 2 CF.sub.3                                                                    CH.sub.3      N                         CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  CF.sub.3                                                                               CH.sub.3      CH                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CF.sub.3                                                                               OCH.sub.3     CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              H             CH                        CH.sub.3  NO.sub.2     H    H  CH.sub.3                                                                               OC.sub.2 H.sub.5                                                                             N                         CH.sub.3  OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                           N                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               CH.sub.2 OCH.sub.3                                                                           CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               CH.sub.2 OCH.sub.2 CH.sub.3                                                                  CH                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                              CH.sub.2 OCH.sub.2 CH.sub.3                                                                  N                         CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              NHCH.sub.3    N                         H         OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                              NHCH.sub.3    CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              N(OCH.sub.3)CH.sub.3                                                                         N                         H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              N(CH.sub.3).sub.2                                                                            N                         CH.sub.3  NO.sub.2     H    H  OCH.sub.3                                                                              N(CH.sub. 3).sub.2                                                                           CH                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               C.sub.2 H.sub.5                                                                              CH                        CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  OCH.sub.3                                                                              C.sub.2 H.sub.5                                                                              N                         H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              CF.sub.3      N                         CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               CF.sub.3      CH                        H         OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                               SCH.sub.3     CH                        CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                              SCH.sub.3     N                         H         CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               OCH.sub.2 C.tbd.CH                                                                           N                         CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              OCH.sub.2 C.tbd.CH                                                                           CH                        H         SO.sub.2 N(CH.sub.2).sub.2                                                                  H    H  OCH.sub.3                                                                              OCH.sub.2 CH═CH.sub.2                                                                    CH                        CH.sub.3  NO.sub.2     H    H  CH.sub.3                                                                               OCH.sub.2 CH═CH.sub.2                                                                    N                         H         OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                              OCH.sub.2 CH.sub.2 OCH.sub.3                                                                 N                         CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               OCH.sub.2 CH.sub.2 OCH.sub.3                                                                 CH                        H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              CH.sub.2 SCH.sub.3                                                                           CH                        CH.sub.3  NO.sub.2     H    H  OCH.sub.3                                                                              CH.sub.2 SCH.sub.3                                                                           N                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               OCF.sub.2 H   CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              SCF.sub.2 H   CH                        H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              SCF.sub.2 H   N                         CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              cyclopropyl   N                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                              cyclopropyl   CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              dimethoxymethyl                                                                              N                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               dimethoxymethyl                                                                              CH                        CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               ethoxymethoxymethyl                                                                          CH                        H         NO.sub.2     H    H  OCH.sub.3                                                                              ethoxymethoxymethyl                                                                          CH                        CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                  H    H  CH.sub.3                                                                               diethoxymethyl                                                                               CH                        H         OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                              diethoxymethyl                                                                               CH                        CH.sub.3  SO.sub.2 CH.sub.2                                                                           H    H  OCH.sub.3                                                                              1,1-dimethoxyethyl                                                                           CH                        H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               1,1-dimethoxyethyl                                                                           CH                        CH.sub.3  OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                               methoxy(methylthio)methyl                                                                    CH                        H         CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              methoxy(methylthio)methyl                                                                    CH                        CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                              bis(methylthio)methyl                                                                        CH                        H         SO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               bis(methylthio)methyl                                                                        CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               1,3-dioxolan-2-yl                                                                            CH                        H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              1,3,dioxolan-2-yl                                                                            N                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               2-methyl-1,3- CH                                                               dioxolan-2-yl                           H         NO.sub.2     H    H  OCH.sub.3                                                                              2-methyl-1,3- CH                                                               dioxolan-2-yl                           CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              1,3-dioxan-2-yl                                                                              CH                        H         OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                               1,3-dioxan-2-yl                                                                              CH                        CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  CH.sub.3                                                                               1,3-oxathiolan-2-yl                                                                          CH                        H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              1,3-oxathiolan-2-yl                                                                          CH                        CH.sub.3  CO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              1,3-dithiolan-2-yl                                                                           CH                        H         OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                               1,3-dithiolan-2-yl                                                                           CH                        CH.sub.3  SO.sub.2 N(CH.sub.3 ).sub.2                                                                 H    H  CH.sub.3                                                                               4-methyl-1,3- CH                                                               dioxolan-2-yl                           H         OSO.sub.2 CH.sub.3                                                                          H    H  OCH.sub.3                                                                              4-methyl-1,3- CH                                                               dioxolan-2-yl                           CH.sub.3  NO.sub.2     H    H  OCH.sub.3                                                                              2,4-dimethyl-1,3-                                                                            CH                                                               dioxolan-2-yl                           H         CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               2,4-dimethyl-1,3-                                                                            CH                                                               dioxolan-2-yl                           CH.sub.3  OSO.sub.2 CH.sub.3                                                                          H    H  CH.sub.3                                                                               5-methyl-1,3- CH                                                               oxathiolan-2-yl                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                  H    H  OCH.sub.3                                                                              5-methyl-1,3- CH                                                               oxathiolan-2-yl                         CH.sub.3  SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              4-methyl-1,3- CH                                                               oxathiolan-2-yl                         H         NO.sub.2     H    H  CH.sub.3                                                                               4-methyl-1,3- CH                                                               oxathiolan-2-yl                         CH        CO.sub.2 CH.sub.3                                                                           H    H  CH.sub.3                                                                               4-methyl-1,3- CH                                                               dithiolan-2-yl                          H         SO.sub.2 CH.sub.3                                                                           H    H  OCH.sub.3                                                                              4-methyl-1,3- CH                                                               dithiolan-2-yl                          __________________________________________________________________________

                                      TABLE 23                                     __________________________________________________________________________     General Structure 23                                                           R.sub.1   R.sub.4                                                                               R  X    Y    Z  m.p. (°C.)                             __________________________________________________________________________     H         Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                               H         Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                               H         Cl     H  Cl   OCH.sub.3                                                                           CH                                               H         Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                                H         Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                                H         Cl     CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           CH                                               CH.sub.3  Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                               CH.sub.3  Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                               CH.sub.3  Cl     H  Cl   OCH.sub.3                                                                           CH                                               CH.sub.3  Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                                CH.sub.3  Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                                CH.sub.2 CH.sub.3                                                                        Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                               (CH.sub.2).sub.2 CH.sub.3                                                                Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                               CF.sub.2 H                                                                               Cl     H  Cl   OCH.sub.3                                                                           CH                                               CH.sub.2 CF.sub.3                                                                        Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                                CH.sub.2 CH.sub.2 OCH.sub.3                                                              Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                                CH.sub.2 CH.sub.2 OH                                                                     Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                               CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                               OH        Cl     H  Cl   OCH.sub.3                                                                           CH                                               Osi(CH.sub.2).sub.3                                                                      Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                                OCH.sub.3 Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                                OCH.sub.2 CH.sub.3                                                                       Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                               SO.sub.2 CH.sub.3                                                                        Cl     H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                               C.sub.6 H.sub.5                                                                          Cl     H  Cl   OCH.sub.3                                                                           CH                                               CH.sub.2 C.sub.6 H.sub.5                                                                 Cl     H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                                CH.sub.3  H      H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                                CH.sub.3  CH.sub.3                                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                               CH.sub.3  OCH.sub.3                                                                             H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                               CH.sub.3  F      H  Cl   OCH.sub.3                                                                           CH                                               CH.sub.3  Br     H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                                CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                            H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                                CH.sub.3  OSO.sub.2 CH.sub.3                                                                    H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                               CH.sub.3  SO.sub.2 CH.sub.3                                                                     H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                               CH.sub.3  Cl     H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                                CH.sub.3  Cl     H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                               CH.sub.3  Cl     H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                               CH.sub.3  Cl     H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                               H         Cl     H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                               H         Cl     H  OCH.sub.3                                                                           C.tbd.CH                                                                            CH                                               __________________________________________________________________________

                                      TABLE 24                                     __________________________________________________________________________     General Structure 24                                                           R.sub.1   R.sub.5     R X    Y      Z  m.p. (°C.)                       __________________________________________________________________________     H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H CH.sub.3                                                                            OCH.sub.3                                                                             CH                                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H Cl   OCH.sub.3                                                                             CH                                         H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H CH.sub.3                                                                            OCH.sub.3                                                                             N                                          H         SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             N                                          H         SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                         OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H CH.sub.3                                                                            OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H Cl   OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H CH.sub.3                                                                            OCH.sub.3                                                                             N                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             N                                          CH.sub.2 CH.sub.3                                                                        SO.sub.2 N(CH.sub. 3).sub.2                                                                H CH.sub.3                                                                            OCH.sub.3                                                                             CH                                         (CH.sub.2).sub.2 CH.sub.3                                                                SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         CF.sub.2 H                                                                               SO.sub.2 N(CH.sub.3).sub.2                                                                 H Cl   OCH.sub.3                                                                             CH                                         CH.sub.2 CF.sub.3                                                                        SO.sub.2 N(CH.sub.3).sub.2                                                                 H CH.sub.3                                                                            OCH.sub.3                                                                             N                                          CH.sub.2 CH.sub.2 OCH.sub.3                                                              SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             N                                          CH.sub.2 CH.sub.2 OH                                                                     SO.sub.2 N(CH.sub.3).sub.2                                                                 H CH.sub.3                                                                            OCH.sub.3                                                                             CH                                         CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         OH        SO.sub.2 N(CH.sub.3).sub.2                                                                 H Cl   OCH.sub.3                                                                             CH                                         OSi(CH.sub.3).sub.3                                                                      SO.sub.2 N(CH.sub.3).sub.2                                                                 H CH.sub.3                                                                            OCH.sub.3                                                                             N                                          OCH.sub.3 SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             N                                          OCH.sub.2 CH.sub.3                                                                       SO.sub.2 N(CH.sub.3).sub.2                                                                 H CH.sub.3                                                                            OCH.sub.3                                                                             CH                                         SO.sub.2 CH.sub.3                                                                        SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         C.sub.6 H.sub. 5                                                                         SO.sub.2 N(CH.sub.3).sub.2                                                                 H Cl   OCH.sub.3                                                                             CH                                         CH.sub.2 C.sub.6 H.sub.5                                                                 SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             N                                          CH.sub.3  CH.sub.3    H CH.sub.3                                                                            OCH.sub.3                                                                             N                                          CH.sub.3  CH.sub.2 CH.sub.3                                                                          H CH.sub.3                                                                            OCH.sub.3                                                                             CH                                         CH.sub.3  OCH.sub.3   H OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         CH.sub.3  OCH.sub.2 CH.sub.3                                                                         H Cl   OCH.sub.3                                                                             CH                                         CH.sub.3  F           H CH.sub.3                                                                            OCH.sub.3                                                                             N                                          CH.sub.3  Cl          H OCH.sub.3                                                                           OCH.sub.3                                                                             N                                          CH.sub.3  Br          H CH.sub.3                                                                            OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                              H Cl   OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H CH.sub.3                                                                            OCH.sub.3                                                                             N                                          CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              H OCH.sub.3                                                                           OCH.sub.3                                                                             N                                          CH.sub.3  SO.sub.2 CH.sub.3                                                                          H CH.sub.3                                                                            OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                 H OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H Cl   OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H CH.sub.3                                                                            OCH.sub.3                                                                             N                                          H         SO.sub.2 CH.sub.3                                                                          H OCH.sub.3                                                                           OCH.sub.3                                                                             N                                          H         OCH.sub.2 CH.sub.3                                                                         H CH.sub.3                                                                            OCH.sub.3                                                                             CH                                         H         Cl          H OCH.sub.3                                                                           OCH.sub.3                                                                             CH                                         H         Br          H Cl   OCH.sub.3                                                                             CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           OCF.sub.2 H                                                                           CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCF.sub.2 H                                                                         OCF.sub.2 H                                                                           CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H CH.sub.3                                                                            CH.sub.3                                                                              CH                                         CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                     N                                          CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H OCH.sub.3                                                                           CH.sub.2 SO.sub.2 CH.sub.3                                                            CH                                         __________________________________________________________________________

                                      TABLE 25                                     __________________________________________________________________________     General Structure 25                                                           L  R.sub.1   R.sub.6     R  X    Y    Z  m.p. (°C.)                     __________________________________________________________________________     L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               H         CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               (CH.sub.2).sub.2 CH.sub.3                                                                CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CF.sub.2 H                                                                               CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.2 CF.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.2 CH.sub.2 OCH.sub.3                                                              CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.2 CH.sub.2 OH                                                                     CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               OH        CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               OSi(CH.sub.3).sub.3                                                                      CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               OCH.sub.3 CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               OCH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               SO.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               C.sub.6 H.sub.5                                                                          CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.2 C.sub.6 H.sub. 5                                                                CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  F           H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  Cl          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  Br          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  SO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                        L-4                                                                               CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                         H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                 H  Cl   OCH.sub.3                                                                           CH                                       L-4                                                                               CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                       L-4                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         N                                        L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub. 3                                                                          OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               H         CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               (CH.sub.2).sub.2 CH.sub.3                                                                CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CF.sub.2 H                                                                               CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.2 CF.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.2 CH.sub.2 OCH.sub.3                                                              CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.2 CH.sub.2 OH                                                                     CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               OH        CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               OSi(CH.sub.3).sub.3                                                                      CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               OCH.sub.3 CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               OCH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               SO.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               C.sub.6 H.sub.5                                                                          CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.2 C.sub.6 H.sub.5                                                                 CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  F           H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  Cl          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  Br          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  SO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub. 3                                                                          CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                        L-5                                                                               CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                         H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                 H  Cl   OCH.sub.3                                                                           CH                                       L-5                                                                               CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                       L-5                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         N                                        L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               H         CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               (CH.sub.2).sub.2 CH.sub.3                                                                CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CF.sub.2 H                                                                               CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub. 3                                                                          CH                                       L-6                                                                               CH.sub.2 CF.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.2 CH.sub.2 OCH.sub.3                                                              CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.2 CH.sub.2 OH                                                                     CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.2 CH.sub.2 OSi(CH.sub.2)3                                                         CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               OH        CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               OSi(CH.sub.3).sub.3                                                                      CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               OCH.sub.3 CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               OCH.sub.2 CH.sub.3                                                                       CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               SO.sub.2 CH.sub.3                                                                        CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               C.sub.6 H.sub.5                                                                          CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.2 C.sub.6 H.sub.5                                                                 CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  F           H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  Cl          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  Br          H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  NO.sub.2    H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.3                                                                 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3).sub.2                                                                 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  SO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                        L-6                                                                               CH.sub.3  CO.sub.2 CH(CH.sub.3).sub.2                                                                H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                         H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                              H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH.sub.3                                                                 H  Cl   OCH.sub.3                                                                           CH                                       L-6                                                                               CH.sub.3  SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                         H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  SO.sub.2 CH.sub.2 CH═CH.sub.2                                                          H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                        L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                       L-6                                                                               CH.sub.3  CO.sub.2 CH.sub.3                                                                          H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         N                                        __________________________________________________________________________

                                      TABLE 26                                     __________________________________________________________________________     General Structure 26                                                                                                           m.p.                           R.sub.9                                                                           R.sub.1   R.sub.7                                                                              R.sub.8                                                                           R.sub.3                                                                              Q.sub.1                                                                          m R  X    Y    Z  (°C.)                   __________________________________________________________________________     H  H         H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  H         H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  H         H     H  H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  H         H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  H         H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  H         H     H  H     O 0 CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.3                                                                        H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  (CH.sub.2).sub.2 CH.sub.3                                                                H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CF.sub.2 H                                                                               H     H  H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 CF.sub.3                                                                        H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.2 OH                                                                     H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  OH        H     H  H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  OSi(CH.sub.3).sub.3                                                                      H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  OCH.sub.3 H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  OCH.sub.2 CH.sub.3                                                                       H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  SO.sub.2 CH.sub.3                                                                        H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  C.sub.6 H.sub.5                                                                          H     H  H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 C.sub.6 H.sub.5                                                                 H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 CH.sub.3                                                                          H         H     H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 CH.sub.3                                                                          CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.3                                                                             H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          H     O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.2 CH.sub.3                                                                    H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                            H  H     O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                            H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-F   O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-Cl  O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-Br  O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-CF.sub.3                                                                           O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  6-CH.sub.3                                                                           O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  5-OCH.sub.3                                                                          O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OCF.sub.2 H                                                                        O 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-OC.sub.2 H.sub.5                                                                   O 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     O 0 H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                H  H         H     H  H     O 0 H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                H  CH.sub.3  H     H  H     O 0 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                 H  CH.sub.3  H     H  H     O 0 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                H  H         H     H  H     O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.2 CH.sub.3                                                                        H     H  H     O 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 CF.sub.3                                                                        H     H  H     O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CF.sub.2 H                                                                               H     H  H     O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          H     O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-F   O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-Cl  O 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-Br  O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  6-CF.sub.3                                                                           O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  5-CH.sub.3                                                                           O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OCH.sub.3                                                                          O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-OCF.sub.2 H                                                                        O 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                   O 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  H         (CH.sub.2).sub.3 CH.sub.3                                                            H  H     O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     O 1 CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     O 1 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                 H  CH.sub.3  H     H  H     O 1 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   CH                                H  (CH.sub.2).sub.2 CF.sub.3                                                                H     H  H     O 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  H         H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  H         H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  H         H     H  H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  H         H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  H         H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  H         H     H  H     S 0 CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.3                                                                        H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  (CH.sub.2).sub.2 CH.sub. 3                                                               H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CF.sub.2 H                                                                               H     H  H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 CF.sub.3                                                                        H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.2 CH.sub.2 OH                                                                     H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  OH        H     H  H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  OSi(CH.sub.3).sub.3                                                                      H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  OCH.sub.3 H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  OCH.sub.2 CH.sub.3                                                                       H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  SO.sub.2 CH.sub.3                                                                        H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  C.sub.6 H.sub.5                                                                          H     H  H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 C.sub.6 H.sub.5                                                                 H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 CH.sub.3                                                                          H         H     H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 CH.sub.3                                                                          CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.3                                                                             H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          H     S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  CH.sub.2 CH.sub.3                                                                    H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                            H  H     S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                            H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-F   S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-Cl  S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-Br  S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-CF.sub.3                                                                           S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  6-CH.sub.3                                                                           S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  5-OCH.sub.3                                                                          S 0 H  CH.sub.3                                                                            OCH.sub. 3                                                                          CH                                H  CH.sub.3  H     H  6-OCF.sub.2 H                                                                        S 0 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-OC.sub.2 H.sub.5                                                                   S 0 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     S 0 H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                         CH                                H  H         H     H  H     S 0 H  OCH.sub.3                                                                           OCF.sub.2 H                                                                         CH                                H  CH.sub.3  H     H  H     S 0 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                 H  CH.sub.3  H     H  H     S 0 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                H  H         H     H  H     S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.2 CH.sub.3                                                                        H     H  H     S 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.2 CF.sub.3                                                                        H     H  H     S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CF.sub.2 H                                                                               H     H  H     S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          H     S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-F   S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-Cl  S 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-Br  S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  6-CF.sub.3                                                                           S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  5-CH.sub.3                                                                           S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OCH.sub.3                                                                          S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  5-OCF.sub.2 H                                                                        S 1 H  Cl   OCH.sub.3                                                                           CH                                H  CH.sub.3  H     H  6-OC.sub.2 H.sub.5                                                                   S 1 H  CH.sub.3                                                                            OCH.sub.3                                                                           N                                 H  H         (CH.sub.2).sub.3 CH.sub.3                                                            H  H     S 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     S 1 CH.sub.3                                                                          OCH.sub.3                                                                           OCH.sub.3                                                                           N                                 H  CH.sub.3  H     H  H     S 1 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   N                                 H  CH.sub.3  H     H  H     S 1 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                   CH                                H  (CH.sub.2).sub.2 CF.sub.3                                                                H     H  H     S 0 H  CH.sub.3                                                                            OCH.sub.3                                                                           CH                                H  H         CH.sub.3                                                                             H  5-OCF.sub.3                                                                          O 1 H  OCH.sub.3                                                                           OCH.sub.3                                                                           CH                                CH.sub.3                                                                          CH.sub.3  H     H  5-SCH.sub.3                                                                          O 0 H  OCH.sub.3                                                                           CH.sub.3                                                                            N                                 H  H         H     H  6-CH.sub.2 CH.sub.3                                                                  S 1 H  CH.sub.3                                                                            CH.sub.3                                                                            CH                                __________________________________________________________________________

                                      TABLE 27                                     __________________________________________________________________________     General Structure 27                                                                                                             m.p.                         R.sub.1   R.sub.10                                                                              R.sub.11                                                                           R.sub.3                                                                               Q.sub.2                                                                           R   X     Y     Z  (°C.)                 __________________________________________________________________________     H         H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                              H         H      H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                              H         H      H   H      O  H   Cl    OCH.sub.3                                                                            CH                              H         H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                               H         H      H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                               H         H      H   H      O  CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                            N                               CH.sub.3  H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                              CH.sub.3  H      H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                              CH.sub.3  H      H   H      O  H   Cl    OCH.sub.3                                                                            CH                              CH.sub.3  H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                               CH.sub.3  H      H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                               CH.sub.2 CH.sub.3                                                                        H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                              (CH.sub.2).sub.2 CH.sub.3                                                                H      H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                              CF.sub.2 H                                                                               H      H   H      O  H   Cl    OCH.sub.3                                                                            CH                              CH.sub.2 CF.sub.3                                                                        H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                               CH.sub.2 CH.sub.2 OCH.sub.3                                                              H      H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                               CH.sub.2 CH.sub.2 OH                                                                     H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    H      H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                              OH        H      H   H      O  H   Cl    OCH.sub.3                                                                            CH                              OSi(CH.sub.3).sub.3                                                                      H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                               OCH.sub.3 H      H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                               OCH.sub.2 CH.sub.3                                                                       H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                              SO.sub.2 CH.sub.3                                                                        H      H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                              C.sub.6 H.sub.5                                                                          H      H   H      O  H   Cl    OCH.sub.3                                                                            CH                              CH.sub.2 C.sub.6 H.sub.5                                                                 H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                               CH.sub.3  CH.sub.3                                                                              H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                               CH.sub.3  CH.sub.3                                                                              CH.sub.3                                                                           H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                              CH.sub.3  CH.sub.2 CH.sub.3                                                                     H   H      O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                              CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                             H   H      O  H   Cl    OCH.sub.3                                                                            CH                              CH.sub.3  (CH.sub.2).sub.3 CH.sub.3                                                             H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                               CH.sub.3  H      H   5-F    O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                               CH.sub.3  H      H   6-Cl   O  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                              CH.sub.3  H      H   5-Br   O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                              CH.sub.3  H      H   6-CF.sub.3                                                                            O  H   Cl    OCH.sub.3                                                                            CH                              CH.sub.3  H      H   5-CH.sub.3                                                                            O  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                               CH.sub.3  H      H   6-OCH.sub.3                                                                           O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                               CH.sub.3  H      H   5-OCF.sub.2 H                                                                         O  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                              CH.sub.3  H      H   6-OC.sub.2 H.sub.5                                                                    O  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                              H         H      H   H      S  H   Cl    OCH.sub.3                                                                            CH                              CH.sub.3  H      H   H      S  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                               CH.sub.2 CH.sub.3                                                                        H      H   H      S  H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                               CH.sub.2 CF.sub.3                                                                        H      H   H      S  H   CH.sub. 3                                                                            OCH.sub.3                                                                            CH                              CF.sub.2 H                                                                               H      H   H      S  H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                              CH.sub.3  CH.sub.3                                                                              CH.sub.3                                                                           H      S  H   Cl    OCH.sub.3                                                                            CH                              CH.sub.3  H      H   5-Cl   S  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                               CH.sub.3  H      H   5-CF.sub.3                                                                            S  H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                               CH.sub.3  H      H   6-CH.sub.3                                                                            S  H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                              CH.sub.3  H      H   H      S  H   CH.sub.3                                                                             CH.sub.3                                                                             CH                              CH.sub.3  H      H   H      O  H   OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                    N                               CH.sub.3  H      H   H      O  H   OCH.sub.3                                                                            OCF.sub.2 H                                                                          CH                              CH.sub.3  H      H   H      O  H   OCF.sub.2 H                                                                          OCF.sub.2 H                                                                          CH                              (CH.sub.2).sub.2 CF.sub.3                                                                H      H   H      O  H   CH.sub.3                                                                             OCH.sub.3                                                                            N                               H         H      H   5-OCF.sub.3                                                                           O  H   CH.sub.3                                                                             CH.sub.3                                                                             CH                              CH.sub.3  H      H   5-C.sub.2 H.sub.5                                                                     S  H   Cl    OCH.sub.3                                                                            CH                              CH.sub.3  H      H   6-CH.sub.2 SCF.sub.3                                                                  O  H   Cl    OCH.sub.3                                                                            CH                              __________________________________________________________________________

                                      TABLE 28                                     __________________________________________________________________________     General Structure 28                                                                                                                  m.p.                    L  R.sub.1    R.sub.12  R.sub.3                                                                               R.sub.9                                                                            m R   X     Y    Z  (°C.)            __________________________________________________________________________     L-9                                                                               H          CH.sub.3  H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           CH                         L-9                                                                               H          CH.sub.3  H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               H          CH.sub.3  H      H   0 H   Cl    OCH.sub.3                                                                           CH                         L-9                                                                               H          CH.sub.3  H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           N                          L-9                                                                               H          CH.sub.3  H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           N                          L-9                                                                               H          CH.sub.3  H      H   0 CH.sub.3                                                                           CH.sub.3                                                                             OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.3   CH.sub.3  H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.3  H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.3  H      H   0 H   Cl    OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.3  H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.3   CH.sub.3  H      H   0 H   OCH.sub. 3                                                                           OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.2 CH.sub.3                                                                         CH.sub.3  H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           CH                         L-9                                                                               (CH.sub.2).sub.2 CH.sub.3                                                                 CH.sub.3  H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               CF.sub.2 H CH.sub.3  H      H   0 H   Cl    OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.2 CF.sub.3                                                                         CH.sub.3  H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.2 CH.sub.2 CF.sub.3                                                                CH.sub.3  H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3  H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.2 CH.sub.2 OH                                                                      CH.sub.3  H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                     CH.sub.3  H      H   0 H   Cl    OCH.sub.3                                                                           CH                         L-9                                                                               OH         CH.sub.3  H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           N                          L-9                                                                               OSi(CH.sub.3).sub.3                                                                       CH.sub.3  H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           N                          L-9                                                                               OCH.sub.3  CH.sub.3  H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           CH                         L-9                                                                               OCH.sub.2 CH.sub.3                                                                        CH.sub.3  H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               SO.sub.2 CH.sub.3                                                                         CH.sub.3  H      H   0 H   Cl    OCH.sub.3                                                                           CH                         L-9                                                                               C.sub.6 H.sub.5                                                                           CH.sub.3  H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.2 C.sub.6 H.sub.5                                                                  CH.sub.3  H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           N                          L-9                                                                               H          H         H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   H         H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.2 CH.sub.3                                                                        H      H   0 H   Cl    OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   (CH.sub.2).sub.2 CH.sub.3                                                                H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.3   (CH.sub.2).sub.3 CH.sub.3                                                                H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.3   (CH.sub.2).sub.4 CH.sub.3                                                                H      H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   (CH.sub.2).sub.5 CH.sub.3                                                                H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               H          CH.sub.3  H      CH.sub.3                                                                           0 H   Cl    OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.3  H      CH.sub.3                                                                           0 H   CH.sub.3                                                                             OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.3   CH.sub.3  6-F    H   0 H   OCH.sub.3                                                                            OCH.sub.                                                                            N                          L-9                                                                               CH.sub.3   CH.sub.3  5-Cl   H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.3  6-Br   H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.3  5-CF.sub.3                                                                            H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.3  6-CH.sub.3                                                                            H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.3   CH.sub.3  5-OCH.sub.3                                                                           H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.3   CH.sub.3  6-OCF.sub.2 H                                                                         H   0 H   CH.sub.3                                                                             OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.3  5-OC.sub.2 H.sub.5                                                                    H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               H          CH.sub.3  H      H   1 H   Cl    OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.3  H      H   1 H   CH.sub.3                                                                             OCH.sub.3                                                                           N                          L-9                                                                               CH.sub.3   CH.sub.3  H      H   1 H   OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                   CH                         L-9                                                                               CH.sub.3   CH.sub.3  H      H   0 H   CH.sub.3                                                                             CH.sub.3                                                                            CH                         L-9                                                                               CH.sub.3   CH.sub.3  H      H   0 H   OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                   N                          L-9                                                                               CH.sub.3   CH.sub.3  H      H   0 H   OCF.sub.2 H                                                                          OCF.sub.2 H                                                                         CH                         L-9                                                                               CH.sub.3   CH.sub. 2 CH.sub.2 Cl                                                                    H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.2 CH.sub.2 Cl                                                                     H      H   0 H   OCH.sub.3                                                                            CH.sub.3                                                                            N                          L-9                                                                               CH.sub.3   CH.sub.2 CH.sub.2 F                                                                      H      H   0 H   OCH.sub.3                                                                            CH.sub.3                                                                            N                          L-9                                                                               CH.sub.3   CH.sub.2 CH.sub.2 F                                                                      H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.2 CF.sub.3                                                                        H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   CH.sub.2 CF.sub.3                                                                        H      H   0 H   OCH.sub.3                                                                            CH.sub.3                                                                            N                          L-9                                                                               CH.sub.3   CH.sub.2 CH.sub.2 Br                                                                     H      H   0 H   OCH.sub.3                                                                            CH.sub.3                                                                            N                          L-9                                                                               CH.sub.3   CH.sub.2 CH.sub.2 OCH.sub.3                                                              H      H   0 H   OCH.sub.3                                                                            CH.sub.3                                                                            N                          L-9                                                                               CH.sub.3   CH.sub.2 CH.sub.2 OCH.sub.3                                                              H      H   0 H   OCH.sub.3                                                                            CH.sub.3                                                                            CH                         L-9                                                                               CH.sub.3   CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                       H      H   0 H   OCH.sub.3                                                                            CH.sub.3                                                                            CH                         L-9                                                                               CH.sub.3   CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                       H      H   0 H   OCH.sub.3                                                                            CH.sub.3                                                                            N                          L-9                                                                               CH.sub.3   (CH.sub.2).sub.3 CH.sub.2 OCH.sub.3                                                      H      H   O H   OCH.sub.3                                                                            CH.sub.3                                                                            N                          L-9                                                                               CH.sub.3   (CH.sub.2).sub.3 CH.sub.2 Cl                                                             H      H   0 H   OCH.sub.3                                                                            CH.sub.3                                                                            CH                         L-9                                                                               H          CO(CH.sub.2).sub.2 CH.sub.3                                                              H      H   0 H   CH.sub.3                                                                             CH.sub.3                                                                            CH                         L-9                                                                               CH.sub.3   CO.sub.2 C.sub.2 H.sub.5                                                                 H      H   0 H   OCH.sub.3                                                                            CH.sub.3                                                                            N                          L-9                                                                               CH.sub.3   CH.sub.2 CF.sub.3                                                                        H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           CH                         L-9                                                                               CH.sub.3   (CH.sub.2).sub.3 CH.sub.2 Br                                                             H      H   0 H   CH.sub.3                                                                             CH.sub.3                                                                            CH                         L-9                                                                               CH.sub.3   CH.sub.2 CH.sub.2 OCH.sub.3                                                              H      H   0 H   OCH.sub.3                                                                            OCH.sub.3                                                                           N                          __________________________________________________________________________

                                      TABLE 28A                                    __________________________________________________________________________     General Structure 28                                                                                                       m.p.                               L  R.sub.1   Q.sub.5                                                                            R.sub.3                                                                             R.sub.9                                                                           m R  X    Y     Z  (°C.)                       __________________________________________________________________________     L-10                                                                              H         O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   H    H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              H         O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              H         O   H    H  0 CH.sub.3                                                                          CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  NCH.sub.3                                                                          H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  NCH.sub.3                                                                          H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  NCH.sub.3                                                                          H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.2 CH.sub.3                                                                        NCH.sub.3                                                                          H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              (CH.sub.2).sub.2 CH.sub.3                                                                NH  H    H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              CF.sub.2 H                                                                               NH  H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.2 CF.sub.3                                                                        NH  H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.2 CH.sub.2 CF.sub.3                                                               NH  H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                              NH  H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.2 CH.sub.2 OH                                                                     O   H    H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              OH        O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              OSi(CH.sub.3).sub.3                                                                      O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              OCH.sub.3 O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              OCH.sub.2 CH.sub.3                                                                       O   H    H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              SO.sub.2 CH.sub.3                                                                        O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              C.sub.6 H.sub.5                                                                          O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                 O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   H    CH.sub.3                                                                          0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   H    CH.sub.3                                                                          0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   5-F  H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  O   6-Cl H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  O   5-Br H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   6-CF.sub.3                                                                          H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   5-CH.sub.3                                                                          H  0 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   H    H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   SCH.sub.3                                                                           H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  O   6-OCH.sub.3                                                                         H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  O   5-OCF.sub.2 H                                                                       H  0 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.3  O   6-OCF.sub.2 H                                                                       H  0 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   H    H  1 H  OCH.sub.3                                                                           OCH.sub.3                                                                            CH                                    L-10                                                                              H         O   H    H  1 H  Cl   OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.2 CH.sub.3                                                                        O   H    H  1 H  CH.sub.3                                                                            OCH.sub.3                                                                            N                                     L-10                                                                              CH.sub.2 CF.sub.3                                                                        O   H    H  1 H  OCH.sub.3                                                                           OCH.sub.3                                                                            N                                     L-10                                                                              CF.sub.2 H                                                                               O   H    H  1 H  CH.sub.3                                                                            OCH.sub.3                                                                            CH                                    L-10                                                                              CH.sub.3  O   H    H  1 H  OCH.sub.3                                                                           OCF.sub.2 H                                                                          CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  OCF.sub.2 H                                                                         OCF.sub.2 H                                                                          CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                           N(CH.sub.3).sub.2                                                                    N                                     L-10                                                                              CH.sub.3  O   H    H  0 H  CH.sub.3                                                                            CH.sub.3                                                                             CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                           OCH.sub.2 CF.sub.3                                                                   N                                     L-10                                                                              CH.sub.3  O   H    H  0 H  OCH.sub.3                                                                           CH.sub.2 OCH.sub.3                                                                   CH                                    L-10                                                                              CH.sub.3  O   H    H  0 H  CH.sub.3                                                                            CF.sub.3                                                                             CH                                    __________________________________________________________________________

                                      TABLE 28B                                    __________________________________________________________________________     General Structure 28                                                           L  R.sub.1                                                                             R.sub.26                                                                          R.sub.27                                                                          R.sub.3                                                                              R.sub.9                                                                           m R  X   Y    Z  m.p. (°C.)                      __________________________________________________________________________     L-11                                                                              CH.sub.3                                                                            H  Cl 6-F   H  1 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  Cl 6-Br  H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  Cl 5-OC.sub.2 H.sub.5                                                                   H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                         L-11                                                                              H    H  Cl OCF.sub.3                                                                            H  1 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                         L-11                                                                              H    H  Cl CH.sub.2 OCH.sub.3                                                                   H  0 H  Cl  OCH.sub.3                                                                           CH                                        L-11                                                                              H    H  H  H     H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                        L-11                                                                              H    H  H  H     H  0 CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  H  H     H  0 H  Cl  OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.2 CH.sub.3                                                                   H  H  H     H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                         L-11                                                                              CH.sub.2 CF.sub.3                                                                   H  H  H     H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                         L-11                                                                              CF.sub.2 H                                                                          H  H  H     H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                        L-11                                                                              OCH.sub.3                                                                           H  H  H     H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                        L-11                                                                              SO.sub.2 CH.sub.3                                                                   H  H  H     H  0 H  Cl  OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  H  H     CH.sub.3                                                                          0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                         L-11                                                                              CH.sub.3                                                                            H  H  5-Cl  H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                         L-11                                                                              CH.sub.3                                                                            H  H  6-CH.sub.3                                                                           H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  H  5-CF.sub.3                                                                           H  0 H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  H  6-OCF.sub.2 H                                                                        H  0 H  Cl  OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            H  H  5-OCH.sub.3                                                                          H  0 H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                         L-11                                                                              H    Cl Cl H     H  1 H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                         L-11                                                                              CH.sub.3                                                                            Cl Cl H     H  1 H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                        L-11                                                                              CH.sub.3                                                                            Cl Cl H     H  1 H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                   N                                         L-11                                                                              CH.sub.3                                                                            Cl Cl H     H  0 H  OCH.sub.3                                                                          OCF.sub.2 H                                                                         CH                                        L-11                                                                              CH.sub.3                                                                            Cl Cl H     H  0 H  CH.sub.3                                                                           CF.sub.3                                                                            CH                                        __________________________________________________________________________

                                      TABLE 28C                                    __________________________________________________________________________     General Structure 28                                                                                                  m.p.                                    L  R.sub.1                                                                             R.sub.12  R.sub.3                                                                              R  X   Y    Z  (°C.)                            __________________________________________________________________________     L-12                                                                              H    CH.sub.3  OCH.sub.2 CF.sub.3                                                                   H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              H    CH.sub.2 CH.sub.3                                                                        CH.sub.2 OCH.sub.3                                                                   H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.3  CH.sub.2 SCH.sub.3                                                                   H  CH.sub.3                                                                           CH.sub.3                                                                            CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 Br                                                   H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              H    CH.sub.2 OC.sub.2 H.sub.5                                                                H     H  CH.sub.3                                                                           CH.sub.3                                                                            CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CF.sub.3                                                                        H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 CH.sub.2 Cl                                                            H     H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              H    COC.sub.2 H.sub.5                                                                        H     H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                         L-12                                                                              H    CO.sub.2 C.sub.2 H.sub.5                                                                 H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              H    CH.sub.3  H     H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                         L-12                                                                              H    CH.sub.3  H     CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH   CH.sub.3  H     H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.2 CF.sub.3                                                                   CH.sub.3  H     H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.2 CH.sub.3                                                                   CH.sub.3  H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              CF.sub.2 H                                                                          CH.sub.3  H     H  CH  OCH.sub.3                                                                           CH                                         L-12                                                                              OCH.sub.3                                                                           CH.sub.3  H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              SO.sub.2 CH.sub.3                                                                   CH.sub.3  H     H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            H         H     H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                        H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.3                                                                            (CH.sub.2).sub.5 CH.sub.3                                                                H     H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  5-F   H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  6-Cl  H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  5-Br  H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.3  6-CF.sub.3                                                                           H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.3  5-CH.sub.3                                                                           H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  6-OCH.sub.3                                                                          H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub. 3 5-OCF.sub.2 H                                                                        H  Cl  OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  6-OC.sub.2 H.sub.5                                                                   H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                          L-12                                                                              H    CH.sub.3  H     H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                   N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.3  H     H  CH.sub.3                                                                           CH.sub.3                                                                            CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.3  H     H  OCH.sub.3                                                                          OCF.sub.2 H                                                                         CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                     H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 Cl                                                                     H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 F                                                                      H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 F                                                                      H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CF.sub.3                                                                        H     H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CF.sub.3                                                                        H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 Br                                                                     H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H  OCH.sub.3                                                                          CH.sub.3                                                                            CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                       H     H  OCH.sub.3                                                                          CH.sub.3                                                                            CH                                         L-12                                                                              CH.sub.3                                                                            CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                       H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            (CH.sub.2).sub.3 CH.sub.2 OCH.sub.3                                                      H     H  OCH.sub.3                                                                          CH.sub.3                                                                            N                                          L-12                                                                              CH.sub.3                                                                            (CH.sub.2).sub.3 CH.sub.2 Cl                                                             H     H  OCH.sub.3                                                                          CH.sub.3                                                                            CH                                         __________________________________________________________________________

                                      TABLE 29                                     __________________________________________________________________________     General Structure 29                                                                                                         m.p.                             L  R.sub.1   R.sub.13                                                                             R.sub.3                                                                               R.sub.14                                                                          R  X   Y      Z  (°C.)                     __________________________________________________________________________     L-13                                                                              H         H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.2 CH.sub.3                                                                        H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              (CH.sub.2).sub.2 CH.sub.3                                                                H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-13                                                                              CF.sub.2 H                                                                               H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.2 CF.sub.3                                                                        H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.2 CH.sub.2 OH                                                                     H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-13                                                                              OH        H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              OSi(CH.sub.3).sub.3                                                                      H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              OCH.sub.3 H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              OCH.sub.2 CH.sub.3                                                                       H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              SO.sub.2 CH.sub.3                                                                        H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-13                                                                              C.sub.6 H.sub.5                                                                          H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                 H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     H      -- CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  CH.sub.3                                                                             H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  CH.sub.2 CH.sub.3                                                                    H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                            H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.3  H     5-F    -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     6-Cl   -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     5-Br   -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     6-CF.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.3  H     5-CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.3  H     6-OCH.sub.3                                                                           -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     5-OCF.sub.2 H                                                                         -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     6-OC.sub.2 H.sub.5                                                                    -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              CH.sub.3  H     H      -- H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-13                                                                              CH.sub.3  H     H      -- H  CH.sub.3                                                                           CF.sub.3                                                                              CH                                  L-13                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                     N                                   L-13                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          OCF.sub.2 H                                                                           CH                                  L-14                                                                              H         H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.2 CH.sub.3                                                                        H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              (CH.sub.2).sub.2 CH.sub.3                                                                H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-14                                                                              CF.sub.2 H                                                                               H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.2 CF.sub.3                                                                        H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                              H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.2 CH.sub.2 OH                                                                     H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-14                                                                              OH        H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-14                                                                              OSi(CH.sub.3).sub.3                                                                      H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              OCH.sub.3 H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              OCH.sub.2 CH.sub.3                                                                       H     H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              SO.sub.2 CH.sub.3                                                                        H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-14                                                                              C.sub.6 H.sub.5                                                                          H     H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                 H     H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     H      -- CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  CH.sub.3                                                                             H      -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  CH.sub.2 CH.sub.3                                                                    H      -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.3  (CH.sub. 2).sub.2 CH.sub.3                                                           H      -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.3  H     5-F    -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     6-Cl   -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     5-Br   -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     6-CF.sub.3                                                                            -- H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.3  H     5-CH.sub.3                                                                            -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-14                                                                              CH.sub.3  H     6-OCH.sub.3                                                                           -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     5-OCF.sub.2 H                                                                         -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     6-OC.sub.2 H.sub.5                                                                    -- H  Cl  OCH.sub.3                                                                             CH                                  L-14                                                                              CH.sub.3  H     H      -- H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-14                                                                              CH.sub.3  H     H      -- H  CH.sub.3                                                                           CF.sub.3                                                                              CH                                  L-14                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                     N                                   L-14                                                                              CH.sub.3  H     H      -- H  OCH.sub.3                                                                          OCF.sub.2 H                                                                           CH                                  L-15                                                                              H         CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  H  OCH.sub. 3                                                                         OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             H      H  H  Cl  OCH.sub.3                                                                             CH                                  L-15                                                                              (CH.sub.2).sub.2 CH.sub.3                                                                CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              CF.sub.2 H                                                                               CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.2 CH.sub.2 OCH.sub.3                                                              CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                             H      H  H  Cl  OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.2 CH.sub.2 Osi(CH.sub.3).sub.3                                                    CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              OH        CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              OSi(CH.sub.3).sub.3                                                                      CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              OCH.sub.3 CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              OCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             H      H  H  Cl  OCH.sub.3                                                                             CH                                  L-15                                                                              SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              C.sub.6 H.sub.5                                                                          CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.2 C.sub.6 H.sub.5                                                                 CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              H         CH.sub.3                                                                             H      H  CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      CH.sub.3                                                                          H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.2 CH.sub.3                                                                    H      H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                            H      H  H  Cl  OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             6-F    H  H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             5-Cl   H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             6-Br   H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             5-CF.sub.3                                                                            H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             6-CH.sub.3                                                                            H  H  Cl  OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             5-OCH.sub.3                                                                           H  H  CH.sub.3                                                                           OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             6-OCF.sub.2 H                                                                         H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              CH.sub.3  CH.sub. 3                                                                            5-OC.sub.2 H.sub.5                                                                    H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-15                                                                              H         CH.sub.3                                                                             6-Cl   H  H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                     N                                   L-15                                                                              CH.sub.3  CH.sub.3                                                                             H      H  H  OCF.sub.2 H                                                                        OCF.sub.2 H                                                                           CH                                  L-13                                                                              H         H     5-C.sub.2 H.sub.5                                                                     -- H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-13                                                                              CH.sub.3  CH.sub.3                                                                             6-OCH.sub.2 CF.sub.3                                                                  -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-13                                                                              CH.sub.3  CH.sub.3                                                                             6-SCH.sub.3                                                                           -- H  Cl  OCH.sub.3                                                                             CH                                  L-13                                                                              H         H     5-CH.sub.2 OCH.sub.3                                                                  -- H  OCH.sub.3                                                                          C.tbd.CH                                                                              CH                                  L-13                                                                              H         H     5-CH.sub.2 SCH.sub.3                                                                  -- H  OCH.sub.3                                                                          CH.sub.2 S(O)CH.sub.3                                                                 N                                   L-14                                                                              H         H     5-C.sub.2 H.sub.5                                                                     -- H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-14                                                                              CH.sub.3  CH.sub.3                                                                             5-OCH.sub.2 CHF.sub.2                                                                 -- H  OCH.sub.3                                                                          OCH.sub.3                                                                             CH                                  L-14                                                                              H         H     6-CH.sub.2 SCH.sub.3                                                                  -- H  CH.sub.3                                                                           OCH.sub.3                                                                             CH                                  L-15                                                                              CH.sub.3  CH.sub.3                                                                             5-SC.sub.2 H.sub. 5                                                                   H  H  CH.sub.3                                                                           CH.sub.3                                                                              CH                                  L-15                                                                              H         CH.sub.3                                                                             6-OCH.sub.2 CH.sub.2 F                                                                H  H  OCH.sub.3                                                                          OCH.sub.3                                                                             N                                   L-15                                                                              H         CH.sub.3                                                                             5-CH.sub.2 OCH.sub.3                                                                  H  H  OCH.sub.3                                                                          CH.sub.2 SO.sub.2 CH.sub.3                                                            N                                   __________________________________________________________________________

                                      TABLE 30                                     __________________________________________________________________________     General Structure 30                                                                                                                m.p.                      BP R.sub.1    R.sub.16     R.sub.15                                                                              R   X     Y     Z  (°C.)              __________________________________________________________________________     5  H          4-Cl         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           5  CH.sub.3   4-Cl         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           5  CH.sub.2 CH.sub.3                                                                         4-Cl         CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                            CH                           5  (CH.sub.2).sub.2 CH.sub.3                                                                 4-Cl         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            N                            5  CF.sub.2 H 4-Cl         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                            5  CH.sub.2 CF.sub.3                                                                         4-Cl         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           5  CH.sub.2 CH.sub.2 OCH.sub.3                                                               4-Cl         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           5  CH.sub.2 CH.sub.2 OH                                                                      4-Cl         CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                            CH                           5  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                     4-Cl         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            N                            5  OH         4-Cl         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                            5  OSi(CH.sub.3).sub.3                                                                       4-Cl         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           5  OCH.sub.3  4-Cl         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           5  OCH.sub.2 CH.sub.3                                                                        4-Cl         CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                            CH                           5  SO.sub.2 CH.sub.3                                                                         4-Cl         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            N                            5  C.sub.6 H.sub.5                                                                           4-Cl         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                            5  CH.sub.2 C.sub.6 H.sub.5                                                                  4-Cl         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           5  H          4-Cl         CH.sub.3                                                                              CH.sub.3                                                                           OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           5  CH.sub.3   H            CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                            CH                           5  CH.sub.3   4-Cl         H      H   CH.sub.3                                                                             OCH.sub.3                                                                            N                            5  CH.sub.3   4-Cl         CH.sub.2 CH.sub.3                                                                     H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                            5  CH.sub.3   4-Cl         (CH.sub.2).sub.2 CH.sub.3                                                             H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           5  CH.sub.3   4-CH.sub.3   CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                            CH                           5  CH.sub.3   4-CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           5  CH.sub.3   4-(CH.sub.2).sub.2 CH.sub.3                                                                 CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            N                            5  CH.sub.3   4-F          CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                            5  CH.sub.3   4-Br         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           5  CH.sub.3   4-NO.sub.2   CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           5  CH.sub.3   4-CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                            CH                           5  CH.sub.3   4-SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            N                            5  CH.sub.3   4-SO.sub.2 N(CH.sub.3)(CH.sub.2).sub.2 CH.sub.3                                             CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                            5  CH.sub.3   4-SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           5  CH.sub.3   4-SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           5  CH.sub.3   4-SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                            CH                           5  CH.sub.3   4-SO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            N                            5  CH.sub.3   4-SO.sub.2 CH.sub.2 CH═CH.sub.2                                                         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                            5  CH.sub.3   4-OCF.sub.2 H                                                                               CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           4  H          3-Cl         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           4  CH.sub.3   3-CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                            CH                           4  CH.sub.3   3-CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub. 3                                                                             H   CH.sub.3                                                                             OCH.sub.3                                                                            N                            4  CH.sub.3   3-CO.sub.2 (CH.sub.2).sub.2 CH.sub.3                                                        CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                            4  CH.sub.3   3-CO.sub.2 (CH.sub.2).sub.3 CH.sub.3                                                        CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           4  CH.sub.3   3-CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           4  CH.sub.3   3-CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                            CH                           4  CH.sub.3   3-CO.sub.2 CH.sub.2 CH═CH.sub.2                                                         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            N                            4  CH.sub.3   3-NO.sub.2   CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                            4  CH.sub.3   5-Br         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           4  CH.sub.3   5-CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           3  H          4-CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H   Cl    OCH.sub.3                                                                            CH                           3  CH.sub.3   4-CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            N                            3  CH.sub.3   4-Cl         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.3                                                                            N                            3  CH.sub.3   4-SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                              H   CH.sub.3                                                                             OCH.sub.3                                                                            CH                           3  CH.sub.3   4-NO.sub.2   CH.sub. 3                                                                             H   OCH.sub.3                                                                            OCH.sub.3                                                                            CH                           3  CH.sub.3   4-F          CH.sub.3                                                                              H   OCF.sub.2 H                                                                          OCF.sub.2 H                                                                          CH                           4  CH.sub.3   3-F          CH.sub.3                                                                              H   CH.sub.3                                                                             CF.sub.3                                                                             CH                           5  CH.sub.3   4-Cl         CH.sub.3                                                                              H   CH.sub.3                                                                             CH.sub.3                                                                             CH                           5  CH.sub.3   4-Br         CH.sub.3                                                                              H   OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                    N                            5  CH.sub.3   4-Cl         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCH.sub.2 CF.sub.3                                                                   N                            5  CH.sub.3   4-Cl         CH.sub.3                                                                              H   OCH.sub.3                                                                            OCF.sub.2 H                                                                          CH                           __________________________________________________________________________      BP = Bridge Position                                                     

                                      TABLE 31                                     __________________________________________________________________________     General Structure 31                                                           R.sub.1   R.sub.15                                                                             R  X   Y    Z  m.p. (°C.)                               __________________________________________________________________________     H         CH.sub.3                                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                                 CH.sub.3  CH.sub.3                                                                             H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                                 CH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             H  Cl  OCH.sub.3                                                                           CH                                                 (CH.sub.2).sub.2 CH.sub.3                                                                CH.sub.3                                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                                  CF.sub.2 H                                                                               CH.sub.3                                                                             H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                                  CH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                                 CH.sub.2 CH.sub.2 OCH.sub.3                                                              CH.sub.3                                                                             H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                                 CH.sub.2 CH.sub.2 OH                                                                     CH.sub.3                                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                                  CH.sub.2 CH.sub.2 OSi(CH.sub.3).sub.3                                                    CH.sub.3                                                                             H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                                  OH        CH.sub.3                                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                                 OSi(CH.sub.3).sub.3                                                                      CH.sub.3                                                                             H  Cl  OCH.sub.3                                                                           CH                                                 OCH.sub.3 CH.sub.3                                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                                  OCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             H  OCH.sub.3                                                                          OCH.sub.3                                                                           N                                                  SO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                           CH                                                 C.sub.6 H.sub.5                                                                          CH.sub.3                                                                             H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                                 CH.sub.2 C.sub.6 H.sub.5                                                                 CH.sub.3                                                                             H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                                  H         CH.sub.3                                                                             CH.sub.3                                                                          OCH.sub.3                                                                          OCH.sub.3                                                                           N                                                  CH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                          CH.sub.3                                                                           OCH.sub.3                                                                           CH                                                 CH.sub.3  CH.sub.2 CH.sub.3                                                                    H  OCH.sub.3                                                                          OCH.sub.3                                                                           CH                                                 CH.sub.3  (CH.sub.2).sub.2 CH.sub.3                                                            H  CH.sub.3                                                                           OCH.sub.3                                                                           N                                                  H         CH.sub.3                                                                             H  CH.sub.3                                                                           CH.sub.3                                                                            CH                                                 CH.sub.3  H     H  Cl  OCH.sub.3                                                                           CH                                                 CH.sub.3  CH.sub.3                                                                             H  OCH.sub.3                                                                          N(CH.sub.3).sub.2                                                                   N                                                  CH.sub.3  CH.sub.3                                                                             H  OCH.sub.3                                                                          OCH.sub.2 CF.sub.3                                                                  CH                                                 CH.sub.3  CH.sub.3                                                                             H  OCH.sub.3                                                                          OCF.sub.2 H                                                                         CH                                                 __________________________________________________________________________

                                      TABLE 32                                     __________________________________________________________________________     General Structure 32                                                                                             m.p.                                         R.sub.1                                                                             R.sub.2                                                                               R.sub.3                                                                             A  R  X.sub.1,2,3 or 4                                                                     Y.sub.1,2,3 or 4                                                                    (°C.)                                 __________________________________________________________________________     H    SO.sub.2 CH.sub.3                                                                     H    A-2                                                                               H  CH.sub.3                                                                             O                                                 CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     H    A-2                                                                               H  CH.sub.3                                                                             O                                                 CH.sub.2 CH.sub.3                                                                   SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-2                                                                               H  CH.sub.3                                                                             O                                                 CH.sub.2 CF                                                                         NO.sub.2                                                                              H    A-2                                                                               H  CH.sub.3                                                                             O                                                 CF.sub.2 H                                                                          SO.sub.2 CH.sub.3                                                                     H    A-2                                                                               H  CH.sub.3                                                                             O                                                 H    SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-2                                                                               H  OCH.sub.3                                                                            CH.sub.2                                          CH.sub.3                                                                            OSO.sub.2 CH.sub.3                                                                    H    A-2                                                                               H  OCH.sub.3                                                                            CH.sub.2                                          H    CO.sub.2 CH.sub.2 CH.sub.3                                                            H    A-2                                                                               H  H     O                                                 CH.sub.3                                                                            NO.sub.2                                                                              H    A-2                                                                               H  H     O                                                 H    SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-2                                                                               H  OCH.sub.3                                                                            O                                                 CH.sub.3                                                                            OSO.sub.2 CH.sub.3                                                                    H    A-2                                                                               H  OCH.sub.3                                                                            O                                                 CH.sub.3                                                                            SO.sub.2 CH.sub.3                                                                     5-OCH.sub.3                                                                         A-2                                                                               H  OCH.sub.3                                                                            O                                                 H    NO.sub.2                                                                              H    A-2                                                                               CH.sub.3                                                                          CH.sub.3                                                                             O                                                 H    SO.sub.2 CH.sub.3                                                                     H    A-3                                                                               H  CH.sub.3                                                                             --                                                CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-3                                                                               H  CH.sub.3                                                                             --                                                CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                     H    A-3                                                                               H  CH.sub.3                                                                             --                                                CH.sub.2 CF.sub.3                                                                   SO.sub.2 CH.sub.3                                                                     H    A-3                                                                               H  CH.sub.3                                                                             --                                                CF.sub.2 H                                                                          OSO.sub.2 CH.sub.3                                                                    H    A-3                                                                               H  CH.sub.3                                                                             --                                                H    SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-3                                                                               H  H     --                                                CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     H    A-3                                                                               H  H     --                                                H    SO.sub.2 CH.sub.3                                                                     H    A-3                                                                               H  OCH.sub.3                                                                            --                                                CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-3                                                                               H  OCH.sub.3                                                                            --                                                CH.sub.2 CF.sub.3                                                                   OSO.sub.2 CH.sub.3                                                                    H    A-3                                                                               H  OCH.sub.3                                                                            --                                                CF.sub.2 H                                                                          CO.sub.2 CH.sub.3                                                                     H    A-3                                                                               H  OCH.sub.3                                                                            --                                                SO.sub.2 CH.sub.3                                                                   SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-3                                                                               H  OCH.sub.3                                                                            --                                                H    OSO.sub.2 CH.sub.3                                                                    H    A-4                                                                               H  CH.sub.3                                                                             CH.sub.3                                          CH.sub.3                                                                            SO.sub.2 CH.sub.3                                                                     H    A-4                                                                               H  CH.sub. 3                                                                            CH.sub.3                                          CH.sub.2 CH.sub.3                                                                   CO.sub.2 CH.sub.3                                                                     H    A-4                                                                               H  CH.sub.3                                                                             CH.sub.3                                          CH.sub.2 CF.sub.3                                                                   NO.sub.2                                                                              H    A-4                                                                               H  CH.sub.3                                                                             CH.sub.3                                          CF.sub.2 H                                                                          SO.sub.2 CH.sub.3                                                                     H    A-4                                                                               H  CH.sub.3                                                                             CH.sub.3                                          H    SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-4                                                                               H  OCH.sub.3                                                                            CH.sub.3                                          CH.sub.3                                                                            SO.sub.2 CH.sub.3                                                                     H    A-4                                                                               H  OCH.sub.3                                                                            CH.sub.3                                          H    NO.sub.2                                                                              H    A-4                                                                               H  H     CH.sub.3                                          CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     H    A-4                                                                               H  H     CH.sub.3                                          H    SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-4                                                                               H  CH.sub.3                                                                             H                                                 CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     H    A-4                                                                               H  CH.sub.3                                                                             H                                                 H    SO.sub.2 CH.sub.3                                                                     H    A-4                                                                               H  OCH.sub.3                                                                            H                                                 CH.sub.3                                                                            OSO.sub.2 CH.sub.3                                                                    H    A-4                                                                               H  OCH.sub.3                                                                            H                                                 H    CO.sub.2 CH.sub.3                                                                     H    A-4                                                                               H  H     H                                                 CH.sub.3                                                                            SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-4                                                                               H  H     H                                                 H    SO.sub.2 CH.sub.3                                                                     H    A-5                                                                               H  CH.sub.3                                                                             OCH.sub.3                                         CH.sub.3                                                                            CO.sub.2 CH.sub.3                                                                     H    A-5                                                                               H  C.sub.2 H.sub.5                                                                      SCH.sub.3                                         C.sub.2 H.sub.5                                                                     SO.sub.2 N(CH.sub.3).sub. 2                                                           H    A-5                                                                               H  CH.sub.2 CF.sub.3                                                                    OCF.sub.2 H                                       H    SO.sub.2 CH.sub.3                                                                     H    A-6                                                                               H  CH.sub.3                                                                             --                                                CH.sub.3                                                                            NO.sub.2                                                                              H    A-6                                                                               H  OCH.sub.3                                                                            --                                                CF.sub.2 H                                                                          CO.sub.2 CH.sub.3                                                                     H    A-6                                                                               H  CH.sub.3                                                                             --                                                H    SO.sub.2 N(CH.sub.3).sub.2                                                            H    A-7                                                                               H  OCH.sub.3                                                                            OCH.sub.3                                         CH.sub.3                                                                            NO.sub.2                                                                              H    A-7                                                                               H  Cl    OCH.sub.3                                         C.sub.2 H.sub.5                                                                     Cl     H    A-7                                                                               H  CH.sub.2 OCH.sub.3                                                                   CH.sub.3                                          CH.sub.2 CF.sub.3                                                                   CO.sub.2 CH.sub.3                                                                     H    A-7                                                                               H  CH.sub.3                                                                             Cl                                                __________________________________________________________________________

Formulations

Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these can be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 5% to 99% solid or liquid diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:

    ______________________________________                                                     Active  Weight Percent*                                                        Ingredient                                                                             Diluent(s)                                                                               Surfactant(s)                                    ______________________________________                                         Wettable Powders                                                                             20-90      0-74     1-10                                         Oil Suspensions,                                                                              5-50     40-95     0-15                                         Emulsions, Solutions,                                                          (including Emulsifiable                                                        Concentrates)                                                                  Aqueous Suspension                                                                           10-50     40-84     1-20                                         Dusts          1-25     70-99     0-5                                          Granules and Pellets                                                                          1-95      5-99     0-15                                         High Strength 90-99      0-10     0-2                                          Compositions                                                                   ______________________________________                                    

Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, N.J., but other solids, either mined or manufactured, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide", 2nd Ed., Interscience, New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., N.Y., 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foam, caking, corrosion, microbiological growth, etc. Preferably, ingredients should be approved by the U.S. Environmental Protection Agency for the use intended.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-59ff.

For further information regarding the art of formulation, see for example:

H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, Col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41;

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, March 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, pp. 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.

In the following examples, all parts are by weight unless otherwise indicated.

EXAMPLE 9

    ______________________________________                                         High Strength Concentrate                                                      ______________________________________                                         2-bromo-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                         98.5%                                              bonyl]-N'--methylbenzenesulfonimidamide                                        silica aerogel              0.5%                                               synthetic amorphous fine silica                                                                            1.0%                                               ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce a high strength concentrate essentially all passing a U.S.S. No. 50 screen (0.3 mm openings). This material may then be formulated in a variety of ways.

EXAMPLE 10

    ______________________________________                                         Aqueous Suspension                                                             2-chloro-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                         25%                                               bonyl]-N'--methylbenzenesulfonimidamide                                        hydrated attapulgite         3%                                                crude calcium ligninsulfonate                                                                               10%                                               sodium hydrogen phosphate    0.5%                                              water                        61.5%                                             ______________________________________                                    

The ingredients are ground together in a ball or roller mill until the solid particles have been reduced to diameters under 10 microns.

EXAMPLE 11

    ______________________________________                                         Aqueous Suspenslon                                                             2-bromo-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                          50%                                               bonyl]-N'--methylbenzenesulfonimidamide                                                                     50%                                               polyacrylic acid thickener   0.3%                                              dodecylphenol polyethylene glycol ether                                                                     0.5%                                              disodium phosphate           1.0%                                              monosodium phosphate         0.5%                                              polyvinyl alcohol            1.0%                                              pentachlorophenol            0.4%                                              water                        46.3%                                             ______________________________________                                    

The ingredients are ground together in a sand mill to produce particles essentially all under 5 microns in size.

EXAMPLE 12

    ______________________________________                                         Wettable Powder                                                                2-nitro-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                          40%                                               bonyl]-N'--methylbenzenesulfonimidamide                                        dioctyl sodium sulfosuccinate                                                                               1.5%                                              sodium ligninsulfonate       3%                                                low viscosity methyl cellulose                                                                              1.5%                                              attapulgite                  54%                                               ______________________________________                                    

The ingredients are thoroughly blended, passed 35 through an air mill, to produce an average particle size under 15 microns, reblended, and sifted through a U.S.S. No. 50 sieve (0.3 mm openings) before packaging.

All compounds of the invention may be formulated in the same manner.

EXAMPLE 13

    ______________________________________                                         Oil Suspension                                                                 2-carbomethoxy-N--[(4,6-dimethoxypyrimidin-2-yl)amino-                                                       25%                                              carbonyl]-N'--methylbenzenesulfonimidamide                                     polyoxyethylene sorbitol hexaoleate                                                                          5%                                               highly aliphatic hydrocarbon oil                                                                             70%                                              ______________________________________                                    

The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water.

EXAMPLE 14

    ______________________________________                                         Wettable Powder                                                                2-bromo-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                          80%                                               bonyl]-N'--methylbenzenesulfonimidamide                                        sodium alkylnaphthalenesulfonate                                                                            2%                                                sodium ligninsulfonate       2%                                                synthetic amorphous silica   3%                                                kaolinite                    13%                                               ______________________________________                                    

The ingredients are blended and then hammer-milled to produce particles of the active ingredient which are essentially less then 50 microns in diameter. The material is reblended before packaging.

EXAMPLE 15

    ______________________________________                                         Extruded Pellet                                                                2-bromo-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                          25%                                               bonyl]-N'--methylbenzenesulfonimidamide                                        anhydrous sodium sulfate     10%                                               crude calcium ligninsulfonate                                                                               5%                                                sodium alkylnaphthalenesulfonate                                                                            1%                                                calcium/magnesium bentonite  59%                                               ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled.

EXAMPLE 16

    ______________________________________                                         Wettable Powder                                                                2-chloro-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                         50%                                               bonyl]-N'--methylbenzenesulfonimidamide                                        sodium alkylnaphthalenesulfonate                                                                            2%                                                low viscosity methyl cellulose                                                                              2%                                                diatomaceous earth           46%                                               ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging.

EXAMPLE 17

    ______________________________________                                         Granule                                                                        Wettable Powder of Example 14                                                                        15%                                                      gypsum                69%                                                      potassium sulfate     16%                                                      ______________________________________                                    

The ingredients are blended in a rotating mixer and water sprayed on to accomplish granulation. When most of the material has reached the desired range of 1.0 to 0.42 mm (U.S.S. #18 to 40 sieves), the granules are removed, dried, and screened. Oversize material is crushed to produce additional material in the desired range. These granules contain 12% active ingredient.

EXAMPLE 18

    ______________________________________                                         Wettable Powder                                                                2-bromo-N--[(4,6-dimethoxypyrimidin-2-yl)aminocar-                                                          65%                                               bonyl]-N'--methylbenzenesulfonimidamide                                        dodecylphenol polyethylene glycol ether                                                                     2%                                                sodium ligninsulfonate       4%                                                sodium silicoaluminate       6%                                                montmorillonite (calcined)   23%                                               ______________________________________                                    

The ingredients are thoroughly blended. The liquid surfactant is added by spraying upon the solid ingredients in the blender. After grinding in a hammer mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) and packaged.

Utility

Test results indicate that the compounds of the present invention are highly active preemergent or postemergent herbicides or plant growth regulants. Many of them have utility for broad-spectrum pre- and/or post-emergence weed control in areas where complete control of all vegetation is desired, such as around fuel storage tanks, ammunition depots, industrial storage areas, parking lots, drive-in theaters, around billboards, highway and railroad structures. Alternatively, the subject compounds are useful to modify plant growth.

The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or as herbicides, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.10 to 10 kg of active ingredient per hectare, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, for selective weed control or for situations where only short-term persistence is required.

The compounds of the invention may be used in combination with any other commercial herbicide; examples of which are those of the triazine, triazole, uracil, urea, amide, diphenylether, carbamate and bipyridylium types.

The herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. The test procedures and results follow. ##STR35##

Test A

Seeds of crabgrass (Digitaria sp.), barnyard-grass (Echinochloa crusgalli), wild oats (Avena fatua), sicklepod (Cassia obtusifolia), morningglory (Ipomoea spp.), cocklebur (Xanthium pensylvanicum), sorghum, corn, soybean, sugarbeet, cotton, rice, wheat and purple nutsedge (Cyperus rotundus) tubers were planted and treated pre-emergence with the test chemicals dissolved in a non-phytotoxic solvent. The crop and weed species on which compounds 3 through 13 were tested did not include sicklepod but did include velvetleaf and cheatgrass. Delivery rates in kg/ha are as indicated.

At the same time, these crop and weed species were treated post-emergence with a soil/foliage application. At the time of treatment, the plants ranged in height from 2 to 18 cm. Treated plants and controls were maintained in a greenhouse for sixteen days, after which all species were compared to controls and visually rated for response to treatment. The ratings, summarized in Table A, are based on a numerical scale extending from 0=no injury, to 10=complete kill. The accompanying descriptive symbols have the following meanings:

C=chlorosis/necrosis;

B=burn;

D=defoliation;

E=emergence inhibition;

G=growth retardation;

H=formative effects;

U=unusual pigmentation; and

X=axillary stimulation.

                                      TABLE A                                      __________________________________________________________________________             Compound 1                                                                            Compound 2                                                                            Compound 3                                                                             Compound 4                                                                             Compound 5                                                                              Compound                                                                                Compound 7             Rate kg/ha                                                                             0.4    0.4    0.4 0.05                                                                               0.4 0.05                                                                               0.4  0.05                                                                               0.4 0.05 0.4                    __________________________________________________________________________     POST-EMERGENCE                                                                 Morningglory                                                                           5C,9G  3C,8H  3C,8G                                                                              2C,7G                                                                              3C,5G                                                                              1C,2G                                                                              10C  3C,7G                                                                              5C,9G                                                                              3C,8G                                                                               5C,9G                  Cocklebur                                                                              3H     4C,9H  3G  3H  0   0   2C,8G                                                                               5G  3C,7G                                                                              3C,6G                                                                               2C,3G                  Sicklepod                                                                              4C,8G  --                                                              Nutsedge                                                                               2C,7G  4C,8G  3C,7G                                                                              3C,8G                                                                              0   0   2G   0   6G  0    4G                     Crabgrass                                                                              4G     2C,7G  3C,6G                                                                              2C  0   0   7G   0   4C,8G                                                                              2G   3C,7G                  Barnyardgrass                                                                          9H     6C,9H  9H  4C,9H                                                                              0   0   5C,9H                                                                               3C,8H                                                                              5C,9H                                                                              3H   3C,7H                  Wild Oats                                                                              4G     4C,9G  3C,7G                                                                              2C,5G                                                                              0   0   2C,3G                                                                               0   3C,3H                                                                              0    0                      Wheat   2G     3C,9G  8G  2C,8G                                                                              0   0   2C,9G                                                                               2G  2C,6G                                                                              0    2G                     Corn    2H     2C,9G  3C,9G                                                                              3C,9G                                                                              2G  0   4C,9G                                                                               9H  2C,8G                                                                              0    7H                     Soybean 5C,9G  4C,8H  4C,9G                                                                              5C,9G                                                                              4H  0   3C.8G                                                                               2H  3C,9G                                                                              2C   5C,9G                  Rice    4G     4C,9G  5G  8G  0   0   5C,9G                                                                               2G  5C,9G                                                                              5G   4C,7G                  Sorghum 0      3C,9G  9H  4C,9H                                                                              1C  0   3C,8H                                                                               3C,3H                                                                              5C,9H                                                                              0    2C,3G                  Sugar beet                                                                             9C     9C     4C,9H                                                                              4C,8H                                                                              3C,6G                                                                              0   5C,9G                                                                               3C,8G                                                                              9C  3C,7H                                                                               5C,9H                  Cotton  9C     10C    3C,7G                                                                              4C,7G                                                                              2C,5G                                                                              0   5C,9G                                                                               3C,5G                                                                              9C  3C,6G                                                                               4C,8H                  Velvetleaf            4C,9G                                                                              8G  2C,6G                                                                              0   5C,9G                                                                               3C,7G                                                                              5C,9H                                                                              3C   4C,8H                  Cheatgrass            9G  2C,8G                                                                              0   0   2C,6G                                                                               5G  4C,7G                                                                              2G   2C,2G                  PRE-EMERGENCE                                                                  Morningglory                                                                           9G     10C    8G  7G  3G  0   9G   6G  9G  8G   9C                     Cocklebur                                                                              9G     8H     7G  7H  5G  0   3C,8H                                                                               5G  9H  5G   5G                     Sicklepod                                                                              9C     --                                                              Nutsedge                                                                               3C,8G  9G     10E 0   0   0   0    0   5G  0    5G                     Crabgrass                                                                              5C,9G  4C,8G  7G  3G  2G  0   3C,7G                                                                               2C,5G                                                                              5C,8G                                                                              4C,8G                                                                               4C,8G                  Barnyardgrass                                                                          6C,9G  6C,9H  9H  9H  0   0   4C,9H                                                                               3G  5C,9H                                                                              2C,4G                                                                               3C,7H                  Wild Oats                                                                              9C     9C     5C,9G                                                                              3C,8G                                                                              0   0   5C,9G                                                                               3C,5G                                                                              5C,9H                                                                              3C,5G                                                                               4C,7G                  Wheat   10C    5C,9H  3C,9G                                                                              8G  0   0   4C,8G                                                                               8G  10H 6G   3C,7H                  Corn    5C,9H  5C,9H  9H  9G  1C  0   4C,9H                                                                               4C,7H                                                                              10H 3C,9H                                                                               4C,8G                  Soybean 4C,8G  4C,8H  4C,6H                                                                              3C,5G                                                                              0   0   3C,5G                                                                               0   4C,8H                                                                              3C,3H                                                                               4C,6H                  Rice    5C,9H  10E    10E 9H  0   0   10E  7H  9H  3G   4C,9H                  Sorghum 5C,9H  5C,9H  4C,9H                                                                              3C,9G                                                                              0   0   4C,9H                                                                               3C,8G                                                                              4C,9H                                                                              3C,4H                                                                               4C,8H                  Sugar beet                                                                             3C,9G  10E    5C,9G                                                                              4C,8G                                                                              5G  0   9C   3C,5G                                                                              9C  4C,8G                                                                               5C,9G                  Cotton  2C,9G  4C,9G  2C,8G                                                                              3C,3H                                                                              2G  0   9G   2C,4G                                                                              4C,8G                                                                              2C,3G                                                                               5C,8G                  Velvetleaf            4C,8G                                                                              3C,8G                                                                              4G  0   5C,8G                                                                               3C,3H                                                                              9C  4C,8H                                                                               9C                     Cheatgrass            9H  8H  0   0   4C,8H                                                                               0   4C,9H                                                                              5G   4C,9G                  __________________________________________________________________________             Compound 7                                                                            Compound 8                                                                             Compound 9                                                                              Compound 10                                                                           Compound 11                                                                            Compound                                                                                Compound 13            Rate kg/ha                                                                             0.05   0.4 0.05                                                                               0.4 0.05 0.4    0.4 0.05                                                                               0.4 0.05 0.02                   __________________________________________________________________________     POST-EMERGENCE                                                                 Morningglory                                                                           2C,5G  5C,9H                                                                              2C,5G                                                                              3C,5G                                                                              3C,5G                                                                               2C,7H  10C 6C,9G                                                                              9C  5C,9G                                                                               4G                     Cocklebur                                                                              1H     3C,5G                                                                              2H  2C,4G                                                                              0    1C,2G  9H  3C,7H                                                                              5C,9G                                                                              4G   2C                     Sicklepod                                                                      Nutsedge                                                                               0      3H  0   2G  0    2C,8G  10C 2C,5G                                                                              2C,5G                                                                              0    2G                     Crabgrass                                                                              0      4C,8G                                                                              2G  3C,4G                                                                              0    2C,5G  9C  3C,8G                                                                              5C,9G                                                                              3C,7G                                                                               0                      Barnyardgrass                                                                          0      4C,9H                                                                              0   2H  0    3C,9H  7C,9H                                                                              4C,9H                                                                              5C,9H                                                                              3C,8H                                                                               2H                     Wild Oats                                                                              0      0   0   0   0    3C,8G  9C  6C,9G                                                                              9C  4C,9G                                                                               0                      Wheat   0      0   0   0   0    3C,9G  5C,9G                                                                              9G  3C,9G                                                                              9G   0                      Corn    0      2C  0   0   0    3C,9H  5C,9G                                                                              5C,9H                                                                              3C,9H                                                                              3C,8H                                                                               1C,2G                  Soybean 2C,4G  5C,9G                                                                              2G  3C,3H                                                                              0    4C,9H  4C,9H                                                                              4C,8H                                                                              4C,9H                                                                              3C,6H                                                                               1H                     Rice    0      2C,5G                                                                              2G  3C,4G                                                                              4G   3C,9G  9C  5C,9G                                                                              9C  5C,9G                                                                               4C,8G                  Sorghum 0      2C,2H                                                                              0   2H  0    9H     4C,9G                                                                              4C,9H                                                                              5C,9H                                                                              4C,9H                                                                               2G                     Sugar beet                                                                             3C,7G  5C,9G                                                                              3C,6G                                                                              3C,6H                                                                              2H   4C,9H  10C 9C  9C  5C,9H                                                                               3C,8H                  Cotton  2C,3G  4C,8G                                                                              6G  3C,5G                                                                              3G   2C,5G  9C  9C  9C  4C,9H                                                                               3C,5H                  Velvetleaf                                                                             2C     5C,9H                                                                              2C,2H                                                                              2C,3G                                                                              1C   2C,8G  10C 6C,9G                                                                              9C  2C,8G                                                                               3C,5H                  Cheatgrass                                                                             0      3C,7G                                                                              0   2C  0    7G     9C  5C,9G                                                                              5C,9G                                                                              3C,9G                                                                               2C                     PRE-EMERGENCE                                                                  Morningglory                                                                           7H     9G  8G  9G  5G   9C     9H  4C,9G                                                                              9G  9G   2C,4G                  Cocklebur                                                                              2C     9H  6H  7H  4G   9H     9H  9H  9H  5H   1H                     Sicklepod                                                                      Nutsedge                                                                               0      8G  2G  2C,5G                                                                              0    10E    4C,9G                                                                              5G  5G  0    0                      Crabgrass                                                                              0      4C,8G                                                                              3C,3G                                                                              3C,8G                                                                              5G   4C,9G  5C,9G                                                                              4C,9G                                                                              4C,9G                                                                              2C,5G                                                                               0                      Barnyardgrass                                                                          0      5C,9H                                                                              4C,8H                                                                              4C,8H                                                                              3G   2C,9G  5C,9H                                                                              4C,9H                                                                              4C,9H                                                                              2C   0                      Wild Oats                                                                              2G     4C,9G                                                                              4C,6G                                                                              5C,9G                                                                              3C,3H                                                                               3C,9G  9C  6C,9G                                                                              6C,9G                                                                              3C,6G                                                                               0                      Wheat   0      5C,9H                                                                              2C,7G                                                                              5C,9H                                                                              4G   3C,9H  6C,9G                                                                              4C,9G                                                                              5C,9H                                                                              2C,6G                                                                               0                      Corn    2C     5C,9H                                                                              4C,8H                                                                              4C,8H                                                                              3C,7H                                                                               3C,9G  3C,9G                                                                              4C,8H                                                                              4C,9H                                                                              3C,6G                                                                               0                      Soybean 2C     3C,7H                                                                              3C,4G                                                                              4C,5G                                                                              2C,2H                                                                               3C,6G  4C,9G                                                                              3C,7H                                                                              3C,7H                                                                              3C,3H                                                                               2G                     Rice    0      10E 2C,6G                                                                              9H  7H   10E    10E 5C,9H                                                                              10E 3C,7G                                                                               2G                     Sorghum 2C,4G  6C,9H                                                                              3C,7H                                                                              5C,9H                                                                              3C   2C,9G  5C,9H                                                                              4C,9H                                                                              5C,9H                                                                              3C,6G                                                                               2C                     Sugar beet                                                                             2C,8G  5C,9G                                                                              4C,8G                                                                              5C,9G                                                                              3C,7G                                                                               5C,9G  9C  5C,9G                                                                              5C,9G                                                                              3C,7H                                                                               5G                     Cotton  2C,4G  3C,7H                                                                              2C,5G                                                                              3C,7G                                                                              2C   4G     9G  4C,8G                                                                              4C,9G                                                                              2C   1C                     Velvetleaf                                                                             2C,5G  9C  3C,8H                                                                              5C,9G                                                                              2C,4G                                                                               5C,9G  9C  9C  9C  4C,6H                                                                               0                      Cheatgrass                                                                             2G     4C,9H                                                                              4C,8G                                                                              5C,9H                                                                              5G   6C,9H  10H 5C,9H                                                                              5C,9H                                                                              2C,6G                                                                               0                      __________________________________________________________________________ 

What is claimed is:
 1. A compound of the formula: ##STR36## wherein R is H or CH₃ ;G is O or NR₁ ; R₁ is H, C₁ to C₃ alkyl, CF₂ H, C₂ to C₃ alkyl substituted with 1 to 3 atoms of F, CH₂ CH₂ OCH₃, CH₂ CH₂ OH, CH₂ CH₂ OSi(CH₃)₃, OH, OSi(CH₃)₃, C₁ to C₂ alkoxy, SO₂ CH₃, phenyl or benzyl; ##STR37## R₂ is C₁ to C₄ alkyl, C₁ to C₄ alkoxy, OCH₂ CH₂ OCH₃, F, Cl, Br, C₁ to C₂ haloalkoxy, C₁ to C₂ haloalkylthio, C₁ to C₂ haloalkylsulfonyl, C₂ to C₃ alkylcarbonyl, NO₂, CO₂ R₁₇, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃, OSO₂ R₂₀, S(O)_(p) R₂₁, C₃ to C₄ alkenyloxy, C₃ to C₄ alkynyloxy, C₁ to C₂ alkyl substituted with OCH₃, OCH₂ CH₃, 1 to 3 atoms of F or Cl, or with 1 Br, C₂ to C₃ alkenyl optionally substituted with 1 to 3F or Cl, C₆ H₅, ##STR38## R₃ is H, F, Cl, Br, CF₃, CH₃, CH₂ CH₃, OCH₃, OCF₂ H, OC₂ H₅, C₁ to C₂ alkylthio, CH₂ SCH₃, CH₂ OCH₃ or C₁ to C₂ alkoxy substituted with 1 to 3F; R₄ is H, CH₃, OCH₃, F, Cl, Br, SO₂ N(CH₃)₂, OSO₂ CH₃ or SO₂ CH₃ ; R₅ is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, F, Cl, Br, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃ or SO₂ R₂₁ ; R₆ is F, Cl, Br, NO₂, CO₂ R₁₇, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃ or SO₂ R₂₁ ; R₇ is H or C₁ to C₄ alkyl; R₈ is H or CH₃ ; R₉ is H or CH₃ ; R₁₀ is H or C₁ to C₄ alkyl; R₁₁ is H or CH₃ ; R₁₂ is H, C₁ to C₆ alkyl, C₂ to C₃ alkoxycarbonyl, C₂ to C₃ alkylcarbonyl or C₂ to C₄ alkyl substituted with Cl, Br, OCH₃ or OC₂ H₅, or with 1 to 3F; R₁₃ is H or C₁ to C₃ alkyl; R₁₄ is H or CH₃ ; R₁₅ is H or C₁ to C₃ alkyl; R₁₆ is C₁ to C₃ alkyl, F, Cl, Br, NO₂, CO₂ R₁₇, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃, SO₂ R₂₁ or OCF₂ H; R₁₇ is C₁ to C₄ alkyl, CH₂ CH₂ OCH₃, CH₂ CH₂ Cl or CH₂ CH═CH₂ ; R₁₈ is C₁ to C₃ alkyl; R₁₉ is C₁ to C₃ alkyl; R₂₀ is C₁ to C₃ alkyl or N(CH₃)₂ ; R₂₁ is C₁ to C₃ alkyl or CH₂ CH═CH₂ ; m is 0 or 1; p is 0, 1 or 2; Q₁ is O or SO₂ ; Q₂ is O or S; ##STR39## X is CH₃, OCH₃, OCH₂ CH₃, CH₂ F, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃ or CF₃ ; Y is H, CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, CH₂ OCH₂ CH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, C₂ H₅, CF₃, SCH₃, OCH₂ C.tbd.CH, amino, CH₂ S(O)CH₃, CH₂ SO₂ CH₃, C.tbd.CH, C.tbd.CCH₃, OCH₂ CH═CH₂, OCH₂ CH₂ OCH₃, CH₂ SCH₃, ##STR40## SCF₂ H or cyclopropyl; n is 2 or 3; Q₃ and Q₄ are independently O or S; Q₅ is O or NR₂₅ ; R₂₂ is H or CH₃ ; R₂₃ and R₂₄ are independently C₁ to C₂ alkyl; R₂₅ is H or C₁ to C₃ alkyl; R₂₆ is H or Cl; R₂₇ is H or Cl; R₂₈ is H or CH₃ ; Z is N; X₃ is CH₃ or OCH₃ ;and their agriculturally suitable salts; provided that (a) when m is 1, then R₉ is H; (b) the total number of carbon atoms of R₁₈ and R₁₉ does not exceed four; (c) when L is L-15, then R₁₃ and R₁₄ are not simultaneously H; (d) when L is L-16, then R₁₆ is adjacent to the substituent ##STR41## and (e) when the total number of carbon atoms of X and Y is greater than four, then R₁ is H or CH₃ and the total number of carbons of the substituents on L does not exceed four.
 2. A compound according to claim 1 wherein G is O and R is H.
 3. A compound according to claim 2 wherein Y is CH₃, OCH₃, CH₂ OCH₃, C₂ H₅, NHCH₃, cyclopropyl or CH(OCH₃)₂, and R₁ is H, C₁ to C₂ alkyl, CH₂ CF₃ or CF₂ H.
 4. A compound according to claim 3 whereinR₂ is C₁ to C₃ alkyl, C₁ to C₃ alkoxy, Cl, Br, NO₂, CF₃, CO₂ R₁₇, SO₂ N(CH₃)₂, OSO₂ R₂₀, SO₂ R₂₁, OCHF₂, ##STR42## R₃ is H, Cl, CH₃ or OCH₃ ; R₄ is CH₃, OCH₃, Cl, Br, OSO₂ CH₃ or SO₂ CH₃ ; R₅ is Cl, SO₂ N(CH₃)₂ or SO₂ CH₃ ; R₆ is Cl, NO₂, CO₂ R₁₇, SO₂ N(CH₃)₂ or SO₂ R₂₁ ; R₇ is H or CH₃ ; R₉ is H; R₁₀ is H or CH₃ ; R₁₁ is H; R₁₂ is H or C₁ to C₄ alkyl; R₁₃ is H or CH₃ ; R₁₅ is CH₃ ; R₁₆ is C₁ to C₂ alkyl, Cl, Br, NO₂, CO₂ CH₃, SO₂ N(CH₃)₂, SO₂ R₂₁ or OCF₂ H; R₁₇ is C₁ to C₃ alkyl; R₂₀ is C₁ to C₃ alkyl; R₂₁ is C₁ to C₂ alkyl; R₂₅ is H or CH₃ ; R₂₈ is H; Q₂ is O; A is A-1; and X is CH₃, OCH₃, OC₂ H₅, or OCH₂ CF₃.
 5. A compound according to claim 4 wherein L is L-1 and R₂ is CH₃, C₂ H₅, CF₃, Br, Cl or SO₂ R₂₁.
 6. A compound according to claim 4 wherein L is L-5 and R₆ is Cl or SO₂ R₂₁.
 7. A compound according to claim 4 wherein L is L-7.
 8. A compound according to claim 4 wherein L is L-9.
 9. A compound according to claim 4 wherein L is L-10.
 10. A compound according to claim 4 wherein L is L-15.
 11. A compound according to claim 4 wherein L is L-16 and R₁₆ is C₁ to C₂ alkyl, Cl, Br or SO₂ R₂₁.
 12. A compound according to claim 1 wherein G is NR₁, R is H, and R₁ is H, C₁ to C₂ alkyl, CH₂ CF₃ or CF₂ H.
 13. A compound according to claim 12 whereinL is L-1, L-5, L-7, L-9, L-10, L-15 or L-16; R₂ is C₁ to C₃ alkyl, C₁ to C₃ alkoxy, Cl, Br, NO₂, CF₃, CO₂ R₁₇, SO₂ N(CH₃)₂, OSO₂ R₂₀, SO₂ R₂₁, OCHF₂, ##STR43## R₃ is H, Cl, CH₃ or OCH₃ ; R₄ is CH₃, OCH₃, Cl, Br, OSO₂ CH₃ or SO₂ CH₃ ; R₅ is Cl, SO₂ N(CH₃)₂ or SO₂ CH₃ ; R₆ is Cl, NO₂, CO₂ R₁₇, SO₂ N(CH₃)₂ or SO₂ R₂₁ ; R₇ is H or CH₃ ; R₉ is H; R₁₀ is H or CH₃ ; R₁₁ is H; R₁₂ is H or C₁ to C₄ alkyl; R₁₃ is H or CH₃ ; R₁₅ is CH₃ ; R₁₆ is C₁ to C₂ alkyl, Cl, Br, NO₂, CO₂ CH₃, SO₂ N(CH₃)₂, SO₂ R₂₁ or OCF₂ H; R₁₇ is C₁ to C₃ alkyl; R₂₀ is C₁ to C₃ alkyl; R₂₁ is C₁ to C₂ alkyl; R₂₅ is H or CH₃ ; R₂₈ is H; Q₂ is O; A is A-1; and X is CH₃, OCH₃, OC₂ H₅, or OCH₂ CF₃.
 14. A compound, 2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-N'-methylbenzenesulfonimidamide.
 15. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 1 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 16. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 2 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 17. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 3 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 18. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 4 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 19. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 5 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 20. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 6 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 21. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 7 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 22. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 8 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 23. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 9 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 24. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 10 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 25. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 11 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 26. A composition of the control of undesirable vegetation consisting essentially of a compound of claim 12 and at least one of (a) a surface active agent and (b) a solid or liquid diluent.
 27. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 13 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 28. A composition for the control of undesirable vegetation consisting essentially of a compound of claim 15 and at least one of (a) a surface active agent, and (b) a solid or liquid diluent.
 29. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 1. 30. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 2. 31. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 3. 32. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 4. 33. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 5. 34. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 6. 35. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 7. 36. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 8. 37. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 9. 38. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 10. 39. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 11. 40. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 12. 41. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 13. 42. A method for the control of undesirable vegetation comprising applying to the locus of such vegetation an herbicidally effective amount of a compound of claim
 15. 